Small-Molecule Inhibitors Block NorA Efflux by Conformational Trapping
Researchers show that small-molecule inhibitors shut down the Staphylococcus aureus NorA efflux pump by trapping the transporter in nonproductive conformational ...
Tag: Antimicrobial Resistance
Azithromycin Resistance in Gonorrhea Shifts Genetic Ground, Challenging Molecular Surveillance
Rising azithromycin resistance in Neisseria gonorrhoeae is increasingly driven by mosaic mtr efflux variants rather than classic 23S rRNA mutations, ...
Mapping 25 Years of Molecular Diagnostics Against WHO Priority Superbugs
A 25-year bibliometric analysis of 1,746 publications reveals how molecular diagnostics for WHO priority bacterial pathogens have reorganized around whole-genome ...
Engineered Viruses Light Up Bacteria in Minutes by Releasing Reporter Proteins
Engineered bacteriophages that carry a split luciferase fragment inside their capsids can detect target bacteria in as little as three ...
Synthetic Oxadiazole Compound Fights Drug-Resistant Burn Wound Bacteria
A synthetic 1,3,4-oxadiazole compound showed potent antibacterial and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa from burn wounds and enhanced the ...
Deadly Fungus Candidozyma auris Shows Higher Adjusted Mortality Risk in Bloodstream Infections
A retrospective cohort study of 301 candidemia patients found that Candidozyma auris bloodstream infections showed nearly doubled adjusted odds of ...
Stealthy Superbug Emerges in Austria as New Vancomycin-Resistant E. faecium Clone Evades Standard Tests
A novel vancomycin-resistant Enterococcus faecium clone designated ST117/CT7799 has driven a sharp rise in invasive infections in South-Eastern Austria while ...
Virulence Plasmid Gives Drug-Resistant SuperbugClone a Decisive Fitness Edge
A sweeping genomic analysis of more than 43,000 Klebsiella pneumoniae genomes shows that stable maintenance of the pLVPK virulence plasmid ...
Last-Resort Antibiotic Resistance Surges Across East Africa in Humans and Environment
A decade-long systematic review finds 12.7 percent of E. coli isolates across East Africa are resistant to last-resort carbapenem antibiotics, ...
Haemolytic Uropathogenic E. coli in Dogs and Cats Reveals Distinct Virulence Patterns
Researchers in Vienna characterised 51 haemolytic uropathogenic E. coli isolates from dogs and cats, finding a dominant B2 phylogroup with ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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