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Spontaneous transfer of mitochondrial DNA into the nuclear genomes in the human brain over the individual’s lifespan

August 22, 2024
in Medicine
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Spontaneous transfer of mitochondrial DNA into the nuclear genomes in the human brain over the individual’s lifespan
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Somatic nuclear mitochondrial DNA (Numt) insertions are mito-nuclear gene transfer events that can arise in the germline and in cancer. This study shows that Numt insertions arise spontaneously and accumulate in brain tissues during development or over the human lifespan.

Spontaneous transfer of mitochondrial DNA into the nuclear genomes in the human brain over the individual’s lifespan

Credit: Lior Kirsch, 2016, PLOS Computational Biology, CC-BY 4.0 (

Somatic nuclear mitochondrial DNA (Numt) insertions are mito-nuclear gene transfer events that can arise in the germline and in cancer. This study shows that Numt insertions arise spontaneously and accumulate in brain tissues during development or over the human lifespan.

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In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology:   

Article Title: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts

Author Countries: United States

Funding: see manuscript



Journal

PLoS Biology

DOI

10.1371/journal.pbio.3002723

Method of Research

Observational study

Subject of Research

Cells

COI Statement

Competing interests: The authors have declared that no competing interests exist.

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