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Home Science News Cancer

Research Aims to Minimize Opioid Dependence and Enhance Pain Management Following Mastectomy

March 6, 2025
in Cancer
Reading Time: 4 mins read
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Bradley Budde
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A revolutionary clinical trial is underway, spearheaded by a dedicated multidisciplinary team at the University of Cincinnati Cancer Center. The main focus of this trial is to optimize postoperative pain management for patients undergoing mastectomy procedures, with the goal of reducing reliance on opioids, a common pain relief option. The urgency of this research is underscored by the ongoing opioid crisis, where the careful balance of pain management and addiction prevention has become a paramount concern for healthcare providers.

Leading this cutting-edge trial are two prominent figures in the field, Alicia Heelan, MD, and Bradley Budde, MD. Their work is made possible through a $50,000 pilot grant supported by the Ride Cincinnati organization, as part of the Cancer Center Pilot Project Award Program. This funding is not only a testament to the significance of their research but also reflects a broader commitment to improving patient outcomes in oncology.

Currently, patients who are slated to undergo mastectomy often receive a pectoralis nerve block, commonly referred to as the PECS block, as a part of their pain management regimen. The PECS block can be administered using two distinct medications: bupivacaine or Exparel (liposomal bupivacaine). Both of these options have received approval from the Food and Drug Administration (FDA) for use in alleviating pain associated with mastectomy, illustrating their established role in surgical care.

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Despite the routine use of these medications in practice, there remains a substantial gap in knowledge regarding the optimal approach to administering these PECS blocks. Current medical practices allow anesthesiologists to administer the blocks before surgery, utilizing ultrasound guidance, while surgeons may opt to inject the medication after the procedure when the patient is still under anesthesia. However, no formal investigation has yet correlated the timing and type of medication used in the blocks with measurable outcomes in patient pain management.

The trial, therefore, is ambitiously set to enroll approximately 100 patients diagnosed with breast cancer, allowing them to participate regardless of whether they are undergoing reconstruction. Patients will be randomly assigned to receive either bupivacaine or Exparel delivered at distinct points during their surgical experience. To further enhance pain management, patients will also be administered non-opioid analgesic medications, such as acetaminophen or ibuprofen, pre-operatively and post-operatively.

Dr. Budde articulates the motivation behind this trial, examining how multi-faceted approaches to pain management can minimize the need for opioid medications, which have historically been the go-to option for pain relief in surgeries. He emphasizes that the healthcare landscape today is shifting towards minimizing opioid dependency after surgery and believes that incorporating various methods in the pain management protocol could yield significant benefits for patients recovering from mastectomy.

An equally important goal of the research is to assess various metrics, including patient satisfaction, the time taken for surgical procedures, and the overall duration of hospital stays. By compiling and analyzing this data, the research team aims to draw meaningful conclusions about the efficacy of pain management techniques, potentially redefining best practices in the context of oncological surgery.

Dr. Heelan, a co-leader of the study, articulates the reassurance provided to patients regarding the comprehensive nature of pain treatment, regardless of their involvement in the trial. The clinical study’s design does not infringe upon the standard care patients are entitled to; rather, it aims to explore and optimize additional strategies to alleviate pain, which is an inherent part of undergoing treatment for breast cancer.

Beyond the immediate consideration of pain management, the implications of this research are profound. Even if it turns out that all techniques utilized do not offer a disparity in their effectiveness, the knowledge gained will equip clinicians with valuable insights for future patient care. The potential to refine and enhance immediate postoperative care standards is invaluable in optimizing the overall healthcare experience for cancer patients.

The funding arrangement through the Cancer Center’s Pilot Project Award Program signifies a strategic effort to foster interdisciplinary collaborations and innovative research endeavors. This funding model is structured to streamline the process for researchers and reviewers, thus promoting exploration within various healthcare fields that ultimately benefit patient populations.

Dr. Heelan acknowledges the substantial impact of the pilot grant on their capacity to undertake the study, stating that the resources provided are indispensable for executing such a vital research initiative. The grant represents a pivotal opportunity to address existing gaps in pain management knowledge and improve surgical outcomes for breast cancer patients, marking a departure from traditional practices toward a more informed approach.

As the clinical trial unfolds, those at the forefront of this research remain hopeful that their findings will not only contribute to academic literature but will also resonate in clinical practices. The growing understanding of pain management in surgical oncology can bolster both providers and patients towards more effective, safer, and evidence-based treatment modalities.

For individuals with a vested interest in participating in this important study, the University of Cincinnati Cancer Center has the resources to facilitate enrollment and is committed to providing comprehensive support throughout the trial. Interested parties are encouraged to reach out for further information about eligibility and enrollment procedures, emphasizing the commitment to advancing cancer care through research.

This clinical trial stands as a beacon of hope in an era where pain management practices must evolve. Tackling the challenges of opioid dependency while ensuring that cancer patients receive the highest quality of care is an endeavor that requires innovative thinking and collective effort from the medical community.

Subject of Research: Optimizing pain management for mastectomy patients while reducing opioid usage
Article Title: Revolutionizing Pain Management: A New Trial Aims to Reduce Opioid Dependence after Mastectomy
News Publication Date: October 2023
Web References: University of Cincinnati
References: Research articles and clinical guidelines on mastectomy pain management
Image Credits: Photo/University of Cincinnati

Keywords: Mastectomy, Pain, Clinical research, Opioids, Drug studies, Breast cancer, Cancer research, Analgesics, Clinical trials, Patient satisfaction, Pain management

Tags: addiction prevention in healthcarebupivacaine versus Exparelclinical trial innovations in pain managementenhancing patient outcomes in oncologymastectomy pain relief strategiesmultidisciplinary cancer researchopioid crisis solutionsopioid dependence reductionoptimizing mastectomy recovery strategiespectoralis nerve block techniquespostoperative pain managementRide Cincinnati funding for cancer research
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