Saturday, August 9, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Cancer

Prostate cancer: Protein identified to reduce tumor growth

June 5, 2024
in Cancer
Reading Time: 3 mins read
0
66
SHARES
600
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT
ADVERTISEMENT

As prostate cancer progresses, it becomes increasingly aggressive and can metastasise. In this form, the tumour is difficult to treat, which is reflected in high mortality rates: Worldwide, the malignant disease of the prostate is the second most common cause of cancer death in men. An international study led by Lukas Kenner (MedUni Vienna) and Sabine Lagger (Vetmeduni Vienna) has now identified a protein that could slow tumour growth. The results, which have just been published in the top journal “Molecular Cancer”, provide a new starting point for the development of therapies.

As prostate cancer progresses, it becomes increasingly aggressive and can metastasise. In this form, the tumour is difficult to treat, which is reflected in high mortality rates: Worldwide, the malignant disease of the prostate is the second most common cause of cancer death in men. An international study led by Lukas Kenner (MedUni Vienna) and Sabine Lagger (Vetmeduni Vienna) has now identified a protein that could slow tumour growth. The results, which have just been published in the top journal “Molecular Cancer”, provide a new starting point for the development of therapies.

The complex molecular processes that lead to the progression of prostate cancer have not yet been fully clarified by science. The protein known as JUN is being intensively researched as a possible driver of tumour growth. “Numerous studies have shown that JUN is produced excessively in cancer. So, a link has been established between tumour growth and high JUN levels,” says Lukas Kenner (Clinical Institute of Laboratory Medicine at MedUni Vienna, Department of Laboratory Animal Pathology at Vetmeduni Vienna), explaining the background to the current study. In collaboration with national and international partners, it was shown that the opposite is the case with prostate cancer: the research team’s investigations using a mouse model and clinical samples revealed that the progression of prostate cancer is not accelerated but slowed down when JUN is present in high levels. On the contrary, it was observed that the tumour grows faster when the protein is missing.

The fact that JUN plays an important role in the activation of genes and various processes such as cell growth was discovered back in the 1980s. “In our investigations, we found that JUN is significantly involved in the regulation of prostate cancer by influencing the body’s immune response,” says Sabine Lagger from the Department of Laboratory Animal Pathology at Vetmeduni Vienna, explaining the connections currently being researched. If the protein is missing, the recruitment of certain immune cells in the tumour’s micro-environment is impaired, which leads to accelerated cancer growth. These results could explain why Prostate cancer is less responsive to immune therapy and could help to understand how to reactivate local immune responses.

Most common cancer in men
Prostate cancer has been the most common cancer in men in Austria for decades. Every year, around 6,000 new cases and 1,300 deaths are registered as a result of prostate cancer. In the vast majority of cases, tumours in the prostate gland remain localised and are therefore easily treatable. However, around 20 per cent of patients develop metastatic prostate cancer, which remains difficult to treat. “Our research suggests that activating JUN could potentially be a promising therapeutic option for slowing the progression of prostate cancer,” Sabine Lagger and Lukas Kenner summarise the significance of their study ahead of further investigations to confirm the results.



Journal

Molecular Cancer

DOI

10.1186/s12943-024-02022-x

Article Title

JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression

Article Publication Date

29-May-2024

Share26Tweet17
Previous Post

Banning false information traffickers online improved public discourse

Next Post

Cannabis use common among patients, with most using it to manage a symptom or health condition

Related Posts

Cancer

Cachexia Index Predicts Gastric Cancer Impact

August 9, 2025
blank
Cancer

Sericin Silver Nanoparticles Combat Colorectal Cancer Effectively

August 9, 2025
blank
Cancer

Immune Checkpoint Inhibitors Linked to Heart Inflammation

August 9, 2025
blank
Cancer

Circulating Hsp70 Signals Early Thoracic Cancer Spread

August 9, 2025
blank
Cancer

Tanshinone IIA Boosts Olaparib Killing Breast Cancer Cells

August 9, 2025
blank
Cancer

Resistance Exercise Boosts Sarcopenia in Breast Cancer

August 9, 2025
Next Post

Cannabis use common among patients, with most using it to manage a symptom or health condition

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27531 shares
    Share 11009 Tweet 6881
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    944 shares
    Share 378 Tweet 236
  • Bee body mass, pathogens and local climate influence heat tolerance

    641 shares
    Share 256 Tweet 160
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    507 shares
    Share 203 Tweet 127
  • Warm seawater speeding up melting of ‘Doomsday Glacier,’ scientists warn

    310 shares
    Share 124 Tweet 78
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Al–Salen Catalyst Powers Enantioselective Photocyclization
  • Shank3 R1117X Mutation Disrupts Behavior, Hippocampal Signaling
  • Emergency Transport’s Effect on Pediatric Cardiac Arrest
  • Neutrino Smarter: Multi-Photosensors Boost Air Shower Arrays

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 4,860 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading