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NIH Awards Grant to Develop Enhanced Delivery Systems for School-Based Substance Use Prevention and Treatment Programs

November 6, 2025
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In a groundbreaking initiative aimed at combating the escalating crisis of substance use disorders among youth, researchers at Wayne State University have embarked on a pioneering project that targets the prevention and early intervention of substance misuse within school environments. Spearheaded by Dr. Andria B. Eisman, associate professor of community health at Wayne State’s College of Education, this two-year endeavor is backed by a substantial $883,176 R61 exploratory grant from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH). The study, aptly named “Reducing Addiction through Prevention Infrastructure Development” (RAPID), is designed to revolutionize how schools serve at-risk adolescents and address the root causes of substance use disorders (SUDs) before they escalate.

The prevalence of opioid and other drug abuse among adolescents remains a pressing public health challenge, exacerbated by socio-economic factors and disparities in access to effective prevention and treatment programs. Dr. Eisman articulates that the essence of this research lies in the critical need for early, proactive measures that disrupt the progression toward chronic substance use. By developing infrastructure within schools, RAPID aims to deliver sustained, multi-tiered prevention services designed to foster resilience and reduce susceptibility among vulnerable youth populations, particularly those marginalized by systemic inequities.

Schools are uniquely positioned to implement evidence-based interventions, given their centrality in adolescents’ daily lives. However, many educational institutions lack the necessary structural and operational frameworks to integrate and maintain substance use prevention programming effectively. This project seeks to bridge that gap by building upon prior research that successfully adapted practices to prevent drug use in educational settings, enhancing both the scalability and longevity of such interventions. The approach integrates collaborative partnerships with state agencies, community organizations, and educational leaders to ensure contextual relevance and cultural competence.

Central to this initiative is the leveraging of Michigan’s unique network of Regional School Health Coordinators, which serves as a vital conduit for disseminating best practices and supporting schools in capacity-building efforts. This strategic utilization of existing resources exemplifies how public health frameworks can be operationalized to create systemic change. Furthermore, RAPID focuses on refining implementation strategies to align with schools’ operational realities, ensuring that prevention measures are not only adopted but also institutionalized for enduring impact.

A pivotal facet of the R61 exploratory phase involves an in-depth examination of viable financing mechanisms to sustain substance use prevention infrastructure within the school system. Identifying sustainable funding streams is indispensable for transitioning from pilot implementations to widespread adoption. To this end, the research team will develop a comprehensive roadmap outlining potential funding opportunities, cost implications, and mechanisms to maximize return on investment while minimizing financial burdens on educational institutions.

Should the exploratory phase validate the feasibility and effectiveness of the RAPID infrastructure model, the team plans to advance to the NIH’s R33 phase. This subsequent stage would facilitate a large-scale, controlled trial to rigorously evaluate cost-effectiveness compared to standard technical assistance approaches. The outcomes are expected to contribute valuable empirical data on long-term benefits, resource allocation, and policy implications, thereby influencing national strategies for youth substance use prevention.

The urgency of this research is underscored by the disproportionate challenges faced by marginalized youth, who not only bear elevated risk factors for developing SUDs but also frequently encounter barriers to accessing timely and appropriate services. By embedding prevention directly within the educational environment, RAPID aims to create a more equitable landscape for intervention, reducing disparities and supporting positive developmental trajectories.

Dr. Ezemenari M. Obasi, vice president for research and innovation at Wayne State University, highlights the broader public health significance of this work. He emphasizes that by pioneering cost-effective and scalable strategies for substance misuse prevention, the project promises to deliver far-reaching societal benefits, including reduced healthcare expenditures and improved quality of life across the lifespan.

The grant supporting this critical work, designated as DA063683, reflects NIH’s commitment to innovative solutions addressing substance use and addiction. Through rigorous multidisciplinary collaboration, the project integrates insights from behavioral psychology, education research, and community health to forge a robust framework for tackling one of the most pressing contemporary health crises.

Wayne State University, renowned for its urban research focus and interdisciplinary endeavors, embodies a model for leveraging academic expertise to address real-world challenges. This project epitomizes the university’s mission to contribute meaningfully to societal welfare, particularly within Detroit and the broader Michigan community, by generating evidence-based interventions with potential for national and global adoption.

The RAPID study represents a promising advancement in the fight against substance use disorders, utilizing prevention-oriented infrastructure development in schools as a frontline defense. By focusing on early intervention, systems-building, and sustainable funding, the initiative aims to reduce the trajectory of addiction epidemics and foster healthier communities through evidence-backed, replicable models.

The research team’s commitment to innovation, equity, and sustainability marks a significant stride toward transforming how educational institutions interface with public health initiatives. This collaborative, systemic approach could serve as a blueprint for addressing complex behavioral health issues in youth populations, underscoring the potential for academic research to translate into impactful community change.

Subject to the success of this exploratory phase, subsequent developments in the RAPID project may radically alter the landscape of preventive health services within schools, providing critical tools and frameworks essential for long-term substance use disorder prevention and intervention efforts.


Subject of Research: Substance use prevention infrastructure development in school settings to reduce adolescent substance use disorders.

Article Title: Reducing Addiction through Prevention Infrastructure Development: Wayne State University’s RAPID Initiative.

News Publication Date: Not specified.

Web References: research.wayne.edu

References: Grant number DA063683 from the National Institute on Drug Abuse of the National Institutes of Health.

Image Credits: Wayne State University.

Keywords: Substance abuse; Education research; Behavioral psychology; Human behavior; Prevention of substance use disorders; Adolescent health; School-based intervention.

Tags: addressing youth substance use disordersadolescent substance abuse interventioncommunity health initiatives for youthearly intervention for substance misuseinnovative delivery systems for addiction treatmentmulti-tiered prevention services in schoolsNational Institute on Drug Abuse fundingNIH grant for substance use preventionopioid abuse prevention strategiesresilience building in at-risk adolescentsschool-based substance use programssocio-economic factors in addiction
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