A groundbreaking study conducted by researchers at the Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP) in Brazil reveals an urgent need to reassess how clinicians monitor and manage muscle mass in women diagnosed with nonmetastatic breast cancer. The research, supported by the São Paulo Research Foundation (FAPESP) and recently published in the peer-reviewed journal Discover Oncology, delineates a direct correlation between skeletal muscle quantity and quality with mortality outcomes in breast cancer patients undergoing chemotherapy. These compelling findings highlight muscle mass as a critical biomarker that influences treatment response, toxicity, and ultimately, survival rates in this population.
Despite the fact that breast cancer remains one of the most prevalent malignancies affecting women worldwide, the intricacies of body composition changes during treatment have received limited attention until now. Muscle tissue functions as a metabolic powerhouse, modulating inflammatory pathways and facilitating drug metabolism. This physiology renders muscle health a decisive factor in how patients tolerate aggressive therapies such as chemotherapy and radiotherapy. Women presenting with diminished muscle mass before treatment initiation were found to be at an elevated risk of chemotherapy-induced toxicity, which can exacerbate complications, delay therapy, and worsen prognosis.
The investigative team embarked on a secondary analysis derived from a comprehensive study targeting metabolic perturbations caused by chemotherapy. Through meticulous assessment involving computed tomography (CT) scans and bioimpedance analysis, the researchers quantified muscle mass and quality, particularly focusing on the cross-sectional area of skeletal muscle at the third lumbar vertebra (L3) level, a validated anatomical landmark for body composition studies. Their cohort consisted of 54 women recently diagnosed with early-stage breast cancer, undergoing baseline evaluation before exposure to oncological interventions.
Integral to the study was the incorporation of phase angle (PhA) measurement via bioimpedance spectroscopy—a novel, non-invasive technique reflecting cellular membrane integrity and body composition. Given that CT imaging may not be universally accessible or feasible in outpatient or low-resource clinical settings, the utilization of phase angle provides an accessible surrogate marker to estimate muscle quality and predict patient outcomes. The study’s findings underscore that a reduced phase angle correlates robustly with lower muscle mass and portends a poorer prognosis.
Nutritionist and lead co-author Mirele Savegnago Mialich Grecco emphasizes the multifaceted challenge breast cancer patients face: they are predisposed to muscle degradation and loss of strength during treatment, often without a commensurate loss in body weight. This scenario is especially prevalent in overweight or obese patients, where adiposity obscures the degree of muscle depletion, creating a deceptive clinical picture that may delay intervention. Grecco asserts that such “hidden” muscle loss undermines the patient’s resilience and can ultimately influence mortality over a five-year span.
Contrary to the more visible cachexia associated with cancers located in gastrointestinal or pulmonary sites, breast cancer patients frequently evade early diagnosis of muscle mass decline due to a lack of pronounced weight loss. This subtlety poses a clinical challenge; without precise body composition analysis, deteriorations in muscle status can remain undetected until they manifest as treatment toxicity or functional decline. This realization advocates for adopting routine muscle assessment protocols in oncology care pathways.
The methodology deployed by the researchers involved leveraging routinely acquired chest CT imaging, extracting images corresponding to the L3 vertebral level to estimate skeletal muscle cross-sectional area and muscle attenuation, the latter being an index of muscle fat infiltration and quality. The coupling of these imaging biomarkers with functional physical tests, including handgrip strength and gait speed, provides an integrative understanding of the patients’ muscular status, which is strongly predictive of treatment outcomes.
Five years post-diagnosis, longitudinal follow-up revealed a stark survival discrepancy tied to muscle status at baseline. Women with lower skeletal muscle mass and diminished phase angles faced significantly higher mortality compared to peers with preserved muscle integrity. The independence of these findings from patient age or cancer stage accentuates the prognostic weight of muscle quantity and quality, advocating for their inclusion as standard parameters in patient evaluation.
These revelations propagate a paradigm shift in breast cancer management, encouraging multidisciplinary teams to incorporate early nutritional interventions aimed at optimizing protein intake immediately upon diagnosis. The rationale pivots on the anabolic demands imposed by cancer treatment, which accelerate muscle catabolism and inflammatory responses. By recommending personalized protein dosages, clinicians can potentially mitigate muscle wasting, preserving physical function and enhancing tolerance to therapy.
Parallel recommendations pertain to physical activity regimens tailored to patient capacity, prioritizing resistance and strength training exercises to retard muscle loss. Such interventions do not necessarily aim to build muscle mass extensively but rather to preserve existing muscle, enabling patients to better endure the rigors of chemotherapy and radiation. Exercise physiology thus emerges as a cornerstone of supportive cancer care.
The broader epidemiological context of breast cancer in Brazil underscores the urgency of these findings. With over 74,000 new annual cases and nearly 18,000 deaths projected between 2023 and 2025, muscle health presents an actionable target within public health strategies to improve survivorship. Despite the high prevalence of low muscle mass—estimated at approximately 40% among breast cancer patients—the absence of routine clinical assessments for muscle wasting reflects a gap that this research seeks to address.
Fundamentally, this study signals a call to arms for oncologists, nutritionists, and rehabilitation specialists to converge on a shared goal: early detection and prevention of muscle depletion. The deployment of accessible tools like bioimpedance analysis to measure phase angle offers an expedient, cost-effective means to monitor patients longitudinally. Ultimately, such measures could transform clinical practice by identifying at-risk individuals and guiding timely interventions.
This research advances the scientific discourse around cancer-associated muscle wasting, a phenomenon long overshadowed by tumor-centric paradigms. By illuminating the prognostic relevance of skeletal muscle integrity, the study champions a holistic patient assessment framework, where metabolic and biomechanical parameters complement oncological staging. This integrative approach promises improved therapeutic outcomes and enhanced quality of life for women battling breast cancer.
Subject of Research: Association of skeletal muscle quantity and quality with mortality in women with nonmetastatic breast cancer
Article Title: Association of skeletal muscle quantity and quality with mortality in women with nonmetastatic breast cancer
News Publication Date: 27-Feb-2025
Web References:
References: Article published in Discover Oncology, DOI: 10.1007/s12672-025-01999-1
Keywords: Breast cancer, Skeletal muscle mass, Muscle quality, Cancer mortality, Chemotherapy toxicity, Body composition, Phase angle, Bioimpedance analysis, Nutritional intervention, Physical exercise, Cancer treatments, Muscle wasting
