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Kathy Coleman Invests $3.5 Million to Advance the Future of Clinical Trials at University Hospitals Seidman Cancer Center

September 4, 2025
in Medicine
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In a transformative move destined to reshape the landscape of cancer treatment, University Hospitals Seidman Cancer Center has received a landmark $3.5 million commitment from philanthropist Kathy Coleman. This generous gift is intended to expand and enhance the clinical trials program, a cornerstone in the search for innovative therapies that extend and improve patient lives. Clinical trials, often the gateway to cutting-edge treatments, are pivotal in the transition from experimental research to real-world medical solutions. The investment reflects a profound dedication to accelerating the pace at which scientific discoveries can benefit patients facing cancer’s relentless challenges.

Since its establishment in 2011, the University Hospitals Seidman Cancer Center has emerged as a beacon of innovation, driven by its comprehensive approach to cancer care. Central to this approach is the Kathy and Les Coleman Clinical Trials Center, which has been instrumental in administering over 400 diverse clinical trials annually. These trials encompass a range of phases and therapeutic strategies, investigating everything from novel drug compounds to revolutionary immunotherapeutic modalities. The infusion of funds will enable a tripling of the center’s capacity by 2030, marking a significant scale-up that will facilitate more extensive patient enrollment and faster integration of breakthroughs into standard care.

Clinical trials represent the pivotal bridge between laboratory science and patient treatment. By systematically evaluating the efficacy and safety of new treatments, they circumvent the limitations of traditional, often slower, methodologies. They allow for the rigorous assessment of experimental agents in controlled settings, ensuring that only the most promising interventions reach widespread application. Importantly, the direct impact of clinical trials on patient care lies in providing individuals with access to novel therapies that may otherwise take years to become widely available or, in some cases, could be the only remaining options.

The University Hospitals Seidman Cancer Center’s affiliation with the Case Comprehensive Cancer Center uniquely positions it at the forefront of oncological research. As one of only seven cancer centers nationwide with direct pipeline access to novel investigational drugs from the National Cancer Institute (NCI), its role in drug development and testing is unparalleled. This strategic advantage means that patients in the Cleveland region gain early access to therapeutics demonstrating potential before such agents are available elsewhere, underscoring the vital importance of integrated research networks in the modern fight against cancer.

Among the most remarkable aspects of UH’s capabilities is its advanced immunotherapy platform, especially in the domain of chimeric antigen receptor T-cell (CAR T-cell) therapy. Unlike the industry standard, which typically demands a manufacturing window of 12 to 30 days, the UH Wesley Center for Immunotherapy manufactures CAR T-cells within just 24 hours. This rapid turnaround not only expedites treatment initiation but also improves clinical outcomes by preserving cell viability and functionality. The new funding will further empower these efforts, propelling the center toward establishing one of the nation’s leading Phase 1 Clinical Trials programs, increasingly focused on first-in-human and early-stage therapeutic trials.

Mrs. Kathy Coleman’s philanthropy is deeply personal and inspirational. Her commitment of over $14 million to University Hospitals, all in loving memory of her late husband Lester Coleman Jr., underscores the intersection of personal loss and the drive to foster a broader community benefit. Lester Coleman Jr., a former industry leader, succumbed to an aggressive form of lung cancer mere months after his diagnosis. This poignant history anchors Mrs. Coleman’s passionate involvement as a volunteer leader and benefactor, reinforcing the indispensable role of private support in expanding clinical research infrastructure.

The upcoming expansion will relocate the clinical trials center into a dedicated 16,000-square-foot facility on the main University Hospitals campus. This spatial enhancement will centralize clinical trial operations, facilitating greater collaboration among multidisciplinary research teams, trial coordinators, and patient care providers. Consolidation of these functions is critical to streamlining workflows, improving patient experience, and integrating novel diagnostic technologies such as theranostics, which combine therapeutic and diagnostic capabilities into a single platform for more precise treatment personalization.

Theranostics and diagnostic-driven trials are rapidly evolving fields that promise to revolutionize how clinicians evaluate and treat cancers. By employing targeted imaging agents alongside therapeutic compounds, researchers can visualize real-time tumor responses and dynamically adjust treatment regimens. This synergistic approach aligns with the broader movement toward precision oncology—tailoring interventions to the unique genetic and molecular profiles of individual tumors—thereby maximizing efficacy while minimizing collateral damage to healthy tissues. The new clinical trial infrastructure at UH Seidman will be critical in facilitating such sophisticated investigations.

Cancer remains one of the most formidable health challenges globally, not only in its biological complexity but also in its profound social and emotional toll. Quintin Pan, PhD, Deputy Director for Research at UH Seidman, highlights how innovative research funded by philanthropy like that of Kathy Coleman’s gift enables the center to continuously push the boundaries of scientific discovery. These discoveries are vital in providing new avenues of hope to patients, especially those with refractory or late-stage disease, who may otherwise face limited options. Clinical trials establish critical proof-of-concept that can shift standard-of-care paradigms and inspire new clinical guidelines.

Moreover, UH’s commitment extends beyond just scientific advancement to delivering highly personalized care close to patients’ homes. The Because of You campaign embodies this ethos with its $2 billion fundraising target, aimed at transforming community health by investing in innovation, discovery, and patient-centered services. Clinical trials embedded within this framework ensure that cutting-edge treatment is not an abstract scientific concept but a tangible option integrated within a broader continuum of care, encompassing prevention, treatment, survivorship, and supportive services.

This campaign is the most ambitious in UH’s 158-year history. It seeks to impact five strategic domains: caring for children, advancing cancer care, leading in discovery and innovation, supporting community health, and embracing emerging medical priorities. By prioritizing clinical trials and translational research, the campaign ensures that investments like Kathy Coleman’s gift have a lasting and progressive impact, refining not only the science but also the clinical infrastructure and delivery models pivotal for next-generation patient care.

University Hospitals Cleveland Medical Center, as the flagship academic medical center, houses a wide array of specialized components integral to this mission. These include the nationally ranked UH Rainbow Babies & Children’s Hospital and the UH MacDonald Women’s Hospital, with Ohio’s only dedicated hospital for women’s health. The system’s size and breadth—with over 20 hospitals, 50 outpatient facilities, and a vast network of providers—create a fertile ecosystem for collaborative research and rapid dissemination of clinical innovations, enabling broader populations to benefit from breakthroughs achieved at the trial center.

Collectively, the advancements facilitated by this philanthropic investment and UH’s research capabilities epitomize the critical synergy between private support, sophisticated infrastructure, and scientific expertise. Such synergy is vital if the promise of precision medicine and immunotherapy is to translate from bench to bedside, transforming cancer care from a reactive to a proactive discipline. As this expanded clinical trials program comes online, it will not only augment the number of patients served but also enhance the pace at which new, potentially life-extending treatments are discovered and delivered, charting an optimistic course for the future of oncology.


Subject of Research: Expansion and enhancement of clinical trials infrastructure and capabilities at University Hospitals Seidman Cancer Center, with special emphasis on novel drug trials, immunotherapy (CAR T-cell manufacturing), and theranostics.

Article Title: Kathy Coleman’s $3.5 Million Gift Accelerates University Hospitals Seidman Cancer Center’s Clinical Trials Innovation

News Publication Date: Not specified

Web References:

  • http://www.uhgiving.org
  • http://www.uhhospitals.org

Image Credits: Photo credit: Roger Mastroianni

Keywords: Health and medicine, Scientific community

Tags: accelerating cancer therapy researchclinical trials expansion investmentcomprehensive cancer treatment programsenhancing patient enrollment in trialsfuture of cancer treatment strategiesimmunotherapy clinical trialsinnovative cancer treatment developmentKathy Coleman donation for cancer researchpatient-centered cancer care initiativesphilanthropic support for medical advancementstransformative impact of clinical trial fundingUniversity Hospitals Seidman Cancer Center funding
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