Monday, August 4, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Medicine

Innovative tissue analysis: Pioneering controllable histotomy with magnetic microneedle array robots

July 31, 2024
in Medicine
Reading Time: 3 mins read
0
Schematic illustration of tumor tissue slicing, manipulation, and cultivation for high-throughput drug screening.
66
SHARES
596
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT

In a pioneering development for the biomedical field, a research team led by Yuanjin Zhao from Nanjing Drum Tower Hospital, China, has published a research article in Engineering. The article, titled “Controllable Histotomy Based on Hierarchical Magnetic Microneedle Array Robots,” introduces a novel technique for tissue slicing and cultivation that could revolutionize the way primary tissues are handled in clinical settings.

Schematic illustration of tumor tissue slicing, manipulation, and cultivation for high-throughput drug screening.

Credit: Xiaoxuan Zhang et al.

ADVERTISEMENT

In a pioneering development for the biomedical field, a research team led by Yuanjin Zhao from Nanjing Drum Tower Hospital, China, has published a research article in Engineering. The article, titled “Controllable Histotomy Based on Hierarchical Magnetic Microneedle Array Robots,” introduces a novel technique for tissue slicing and cultivation that could revolutionize the way primary tissues are handled in clinical settings.

The in vitro cultivation of patient-derived tissues is crucial for accurate diagnosis, precision medication, individualized therapy, and tissue engineering. However, current tissue slicing and cultivation techniques often fall short of clinical requirements. The research team’s innovative approach addresses these challenges by introducing a controllable histotomy strategy that utilizes hierarchical magnetic microneedle array robots.

This strategy involves a three-dimensionally printed, mortise-tenon-structured slicing device, coupled with a magnetic-particle-loaded and pagoda-shaped microneedle array scaffold. The multilayered structure of the microneedles allows for the effective fixation of tissue specimens, avoiding tissue slipping during the slicing process. Moreover, the encapsulated magnetic microneedle fragments enable the tissue pieces to act as magnetically responsive biohybrid microrobots, facilitating their separation, transportation, and dynamic culture through magnetic fields.

The team demonstrated the technique’s efficacy by tailoring primary pancreatic cancer tissues into tiny pieces and culturing them in multilayered microfluidic chips for high-throughput drug screening. The results indicate the promising future of this technique in clinical settings, offering a significant step forward in the precision medicine landscape.

“The development of this controllable histotomy technique marks a significant advancement in the field of tissue engineering and drug screening,” said Jiaming Wu, the editor of Engineering. “By leveraging the capabilities of magnetic microneedle array robots, researchers have been able to create a more efficient and precise method for tissue manipulation and analysis.”

The research article also discusses the potential for further improvements to the technique, such as automating the horizontal sectioning and production of tissue cubes, and scaling up the microtomy device for higher throughput. Additionally, the team envisions the application of this technology beyond cancer research, to other types of patient-derived primary tissues, and its potential for long-term tissue cultivation and observation.

The innovative work by Yuanjin Zhao’s team not only pushes the boundaries of current tissue analysis techniques but also opens up new possibilities for personalized medicine and the development of more effective treatments. As the technology matures, it is expected to play a pivotal role in the advancement of biomedical research and clinical applications.

The paper “Controllable Histotomy Based on Hierarchical Magnetic Microneedle Array Robots,” authored by Xiaoxuan Zhang, Hanxu Chen, Taiyu Song, Jinglin Wang, Yuanjin Zhao. Full text of the open access paper: https://doi.org/10.1016/j.eng.2024.05.004. For more information about the Engineering, follow us on X (https://twitter.com/EngineeringJrnl) & like us on Facebook (https://www.facebook.com/EngineeringJrnl).



Journal

Engineering

DOI

10.1016/j.eng.2024.05.004

Article Title

Controllable Histotomy Based on Hierarchical Magnetic Microneedle Array Robots

Article Publication Date

21-May-2024

Share26Tweet17
Previous Post

Ochsner Health selects DeepScribe to bring ambient AI to clinicians

Next Post

New report shows greater interest in labor unions, especially among young workers

Related Posts

blank
Medicine

Anemia Trends and Causes in Asian Children

August 4, 2025
blank
Medicine

Mental Health Links Gambling Severity to Suicidal Thoughts

August 4, 2025
blank
Medicine

Sex Determination from Mexican Postcranial Long Bones

August 4, 2025
blank
Medicine

Just 15 Minutes in Nature Boosts Mental Health for City Dwellers, Study Finds

August 4, 2025
blank
Medicine

CAR Macrophages Delivered via mRNA EVs Reduce Lung Metastasis

August 4, 2025
blank
Medicine

Perampanel Monotherapy Benefits Children’s New Epilepsy

August 4, 2025
Next Post
New report shows greater interest in labor unions, especially among young workers

New report shows greater interest in labor unions, especially among young workers

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27529 shares
    Share 11008 Tweet 6880
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    939 shares
    Share 376 Tweet 235
  • Bee body mass, pathogens and local climate influence heat tolerance

    640 shares
    Share 256 Tweet 160
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    506 shares
    Share 202 Tweet 127
  • Warm seawater speeding up melting of ‘Doomsday Glacier,’ scientists warn

    310 shares
    Share 124 Tweet 78
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Decoding Modern Social Sciences and Humanities Epistemology
  • Oral Toxicity of Small Polyamide Microplastics Evaluated
  • First Molecular Detection of Trypanosoma theileri in Turkish Cattle
  • New Molecular Markers Reveal Lung Cancer Cardiac Cachexia

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 5,184 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading