Wednesday, October 8, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Cancer

How Breastfeeding Boosts Babies’ Immunity: New Discoveries Unveiled

October 8, 2025
in Cancer
Reading Time: 4 mins read
0
blank
65
SHARES
592
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT

A groundbreaking study has shed new light on the profound impact of breastfeeding on infant immune health, revealing intricate biochemical pathways that underpin its protective effects against infections and chronic inflammation. This research, conducted by leading scientists at the Murdoch Children’s Research Institute (MCRI) in collaboration with the Baker Heart and Diabetes Institute, uncovers how specific lipids found uniquely in breastmilk orchestrate a reduction in inflammatory responses during infancy—an insight that holds promise for enhancing health outcomes in all children, including those unable to be breastfed.

The research focuses on the lipidomic profile of infants who have been breastfed for at least six months, linking their lower incidence of infections and diminished markers of chronic inflammation to the presence of rare, bioactive lipid molecules. Breastfeeding’s broad immunological benefits have long been recognized, but this study dives much deeper into the molecular constituents of breastmilk, particularly a class of lipids known as plasmalogens. These molecules, which are essentially absent in infant formula, appear to play a pivotal role in modulating the neonatal immune environment, mitigating inflammatory cascades that can predispose infants to a variety of chronic conditions later in life.

Lipids, a diverse group of essential nutrients, form the structural and functional foundation of cellular membranes and act as signaling molecules in immune responses. Using plasma samples from nearly 900 infants enrolled in the Barwon Infant Study—a large-scale longitudinal birth cohort study in Australia—the researchers performed an exhaustive analysis of approximately 800 individual lipids and related metabolic markers. This comprehensive profiling identified significant alterations in the plasma lipidome of breastfed infants compared to their non-breastfed peers, pointing to systemic metabolic changes induced by breastfeeding.

Among the lipids scrutinized, plasmalogens emerged as uniquely abundant in the plasma of breastfed infants. Plasmalogens are ether phospholipids known for their antioxidant properties and ability to maintain membrane integrity under oxidative stress. Their role in immune regulation is increasingly recognized, as they can dampen pro-inflammatory signaling pathways and maintain redox balance within immune cells. The study posits that the high concentration of plasmalogens in breastmilk may be a critical factor in curbing systemic inflammation in infants, which is crucial during this vulnerable developmental period when their immune system is still maturing.

Dr. Toby Mansell of MCRI emphasized that the presence of plasmalogens exclusively in breastmilk highlights a significant nutritional gap in infant formulas, which could potentially be addressed by incorporating these lipids synthetically or through novel supplementation strategies. Understanding the precise mechanisms by which plasmalogens exert their anti-inflammatory effects could pave the way for innovative therapies aimed at infants who cannot be breastfed, thereby equipping them with similar immunological defenses as their breastfed counterparts.

The implications of these findings extend far beyond preventing acute infections. Chronic low-grade inflammation during infancy has been implicated in the etiology of a range of pediatric conditions such as allergies, asthma, and metabolic disorders like diabetes. By elucidating how breastfeeding mediates systemic metabolic and immunological shifts, the study provides a compelling biological rationale for global public health initiatives advocating exclusive breastfeeding for at least the first six months of life.

Contributing to the study, Dr. Satvika Burugupalli from the Baker Institute highlighted the multifaceted nature of breastmilk, which is not simply nourishment but a complex bioactive fluid containing antibodies, immune cells, and a tailored lipid profile that collectively condition the infant’s immune system. This intricate biological synergy appears instrumental in establishing a balanced immune milieu, reducing the risk of aberrant inflammatory responses that could culminate in chronic disease.

Moreover, the research collaborated with institutions such as the University of Melbourne, Deakin University, Barwon Health, Northwestern University, and the Florey Institute of Neuroscience and Mental Health, reflecting a robust interdisciplinary approach integrating immunology, metabolomics, and pediatric epidemiology. This confluence of expertise enhances the credibility and translational potential of the findings, underscoring the importance of collaborative science in addressing complex health issues.

The data also align with emerging insights from Generation Victoria (GenV), a large prospective cohort study led by MCRI, which collects extensive biological specimens, including thousands of breast milk and infant stool samples. This resource allows for unprecedented longitudinal tracking of nutritional, microbiome, and immune parameters, thereby complementing and extending the initial observations made in the Barwon Infant Study. The amalgamation of these data sets promises to deepen our understanding of how early-life nutrition shapes lifelong health trajectories.

By deploying advanced metabolomic platforms and applying rigorous mediation analysis, the research team was able to dissect the pathways linking breastfeeding, lipid metabolic alterations, and reductions in inflammation. This analytical framework transcends simple observational correlations, offering mechanistic insights that could inform both nutritional guidance and the development of targeted interventions to mitigate early inflammatory risks.

As global health organizations emphasize the critical importance of breastfeeding, this study provides concrete molecular evidence supporting such recommendations. It also raises urgent questions about how infant formula can be reformulated to mimic the immunoprotective properties of breastmilk more closely. Future research inspired by these findings may unravel additional bioactive compounds in breastmilk and decipher their roles, enabling the design of next-generation infant nutrition that approximates the natural gold standard.

In conclusion, the intricate interplay between breastmilk-derived lipids and infant inflammation revealed by this study marks a significant scientific advance. It underscores breastfeeding not only as an optimal nutritional strategy but as a sophisticated immunomodulatory process crucial for infant development and long-term health. This work opens exciting new avenues for translational research aimed at bridging immunological disparities in infancy and reducing the burden of chronic childhood and adult diseases through improved early-life nutrition.


Subject of Research: People

Article Title: The protective effect of breastfeeding on infant inflammation: a mediation analysis of the plasma lipidome and metabolome

Web References:

  • Murdoch Children’s Research Institute: https://www.mcri.edu.au/
  • Baker Heart and Diabetes Institute: https://www.baker.edu.au/
  • Barwon Infant Study: https://www.barwonhealth.org.au/service/barwon-infant-study/
  • BMC Medicine: https://bmcmedicine.biomedcentral.com/
  • DOI: https://doi.org/10.1186/s12916-025-04343-0
  • GenV (Generation Victoria): https://www.genv.org.au/

References:
Burugupalli S., Mansell T., Wang T., George A.D., Paul S., Saffery R., Tang M.L.K., McDade T.W., Beyene H.B., Duong T., Vuillermin P., Ponsonby A.-L., Barwon Infant Study Investigator Group, Burgner D.P., Meikle P.J. The protective effect of breastfeeding on infant inflammation: a mediation analysis of the plasma lipidome and metabolome. BMC Medicine. DOI: 10.1186/s12916-025-04343-0

Keywords: Breastfeeding, Immune disorders, Infectious diseases

Tags: bioactive lipids in breastmilkbiochemical pathways in breastmilkbreastfeeding benefits for infant immunitybreastfeeding research findingsbreastfeeding vs infant formula nutritionenhancing health outcomes for childrenimmune health in infantsimpact of breastfeeding on chronic inflammationlipidomic profile of breastmilkMurdoch Children's Research Institute studyplasmalogens and infant healthreducing infections through breastfeeding
Share26Tweet16
Previous Post

Dual HDAC/PI3K Inhibitors Trigger Apoptosis in p53-Mutant Lymphoma

Next Post

AI Mimics Pathologists for Clear Prostate Cancer Grading

Related Posts

blank
Cancer

Scientists Develop Radiotheranostic Strategy to Target Aggressive Cancers

October 8, 2025
blank
Cancer

How Smoking and Biological Sex Influence Healthy Bladder Tissue Development: New Insights into Cancer Risk

October 8, 2025
blank
Cancer

Advanced Genetic Tool Uncovers Hidden Mutations Driving Cancer Progression

October 8, 2025
blank
Cancer

Association for Molecular Pathology Creates Standardized Biomarker Report Template to Aid Healthcare Providers

October 8, 2025
blank
Cancer

Extracellular Vesicles: New Frontiers in Cancer Care

October 8, 2025
blank
Cancer

Defective DNA Repair Linked to Nectin-4 in UTUC

October 8, 2025
Next Post
blank

AI Mimics Pathologists for Clear Prostate Cancer Grading

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27564 shares
    Share 11022 Tweet 6889
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    972 shares
    Share 389 Tweet 243
  • Bee body mass, pathogens and local climate influence heat tolerance

    646 shares
    Share 258 Tweet 162
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    514 shares
    Share 206 Tweet 129
  • Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function

    480 shares
    Share 192 Tweet 120
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Photon Pairs: Double Compton Scatter Tested
  • Tracking NF-kB Activity During Neutrophil Maturation
  • Impact of Agriculture on Lahore’s Air Quality: CMAQ Findings
  • Telehealth in Wartime Sudan: Challenges for Displaced Persons

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Blog
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 5,186 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading