In a groundbreaking advancement poised to tackle iron deficiency on a global scale, researchers at MIT have engineered an innovative method to fortify foods and beverages with iron, utilizing a novel class of materials known as metal-organic frameworks (MOFs). This pioneering approach, detailed in a forthcoming article in the journal Matter, introduces a crystalline particle designed to integrate seamlessly with a vast array of staple foods and drinks, offering a promising solution for the approximately two billion people worldwide affected by iron deficiency.
Iron deficiency is a pervasive nutritional problem linked to anemia, impaired cognitive development in children, and heightened rates of infant mortality. Conventional fortification methods often grapple with the reactivity of iron when added to foods, leading to undesirable taste changes and diminished bioavailability. Moreover, many nutrients are chemically unstable during storage and cooking, further complicating fortification efforts. MIT’s new approach leverages the unique properties of MOFs—a class of materials composed of metal ions connected by organic ligands forming highly porous, cage-like structures—to encapsulate iron in a way that preserves its stability and maintains the sensory integrity of fortified foods.
The researchers developed a specific MOF, denoted as NuMOF, which incorporates iron as a central metal ion bound to fumaric acid, a food-grade ligand widely used as a flavor enhancer and preservative. This structure effectively isolates iron atoms, preventing them from interacting with polyphenols—natural compounds found in many foods and beverages like coffee, tea, nuts, and whole grains—that typically bind iron in forms inaccessible to human absorption. By preserving iron’s bioavailability, NuMOF opens new doors for iron supplementation without the common issues of metallic taste or nutritional degradation.
Moreover, NuMOF particles are designed to remain chemically stable under typical storage and preparation conditions, including exposure to heat and humidity, which are often encountered in real-world food supply chains. The intricate cage-like architecture of MOFs allows them to endure boiling temperatures and prolonged storage periods without loss of structural integrity. Once ingested, these MOFs remain intact until they reach the acidic environment of the stomach, where they disintegrate and release their iron payload optimally for absorption.
Simultaneously addressing iodine deficiency, a critical public health concern, the MIT team engineered NuMOF particles to carry iodine along with iron, thereby enabling the creation of “double-fortified” salts and other food products. Traditionally, combining iron and iodine in fortification formulations has been challenging, as the two can chemically react and compromise absorption efficacy. By encapsulating iron within the MOF and loading iodine into the particle’s porous matrix, the researchers achieved a stable, non-reactive vehicle capable of delivering both vital micronutrients concurrently.
Their experimental evaluations included rigorous stability testing under various environmental stresses typical of food distribution networks, such as exposure to moisture and high temperatures. Impressively, NuMOFs maintained their crystalline structure and functional properties throughout. In vivo studies involving mice demonstrated that iron and iodine from NuMOF fortification reached systemic circulation within hours post-consumption, validating the bioavailability and potential effectiveness of this technology for human nutrition.
This advancement also addresses previous limitations encountered when encapsulating iron in polymers for food fortification. While polymer encapsulation enhances iron stability, it introduces bulk that limits nutrient density, hindering the ability to meet daily dietary requirements through typical food portions. In contrast, MOFs use iron itself as a fundamental building component, dramatically increasing loading efficiency and enabling higher doses of nutritional minerals without altering the volume or texture of fortified food products.
Beyond iron and iodine, the researchers envisage adapting this platform to include essential minerals like zinc, calcium, and magnesium, broadening the impact of MOF-based fortification technologies. The versatility and modularity of MOFs make them exciting candidates for next-generation nutrient delivery systems capable of being tailored to the specific nutritional needs of populations worldwide.
The MIT team is actively pursuing commercialization of NuMOF-enhanced products, targeting coffee and other beverages as initial platforms for iron and iodine fortification. Additionally, efforts are underway to develop double-fortified salts that can be incorporated either directly into diets or embedded within various staple foods, catering to diverse culinary landscapes and cultural preferences. This adaptability is crucial considering that staple diets vary significantly across regions such as Senegal, India, and the United States.
Underpinning this research is a commitment to global health, particularly in developing countries where malnutrition imposes a heavy toll on communities. By engineering a nutrient delivery system that is both technologically sophisticated and pragmatically suitable for mass food distribution, these innovations hold the promise of reducing iron deficiency-related diseases at scale.
The project was partially funded by the J-WAFS Fellowships for Water and Food Solutions, emphasizing the interdisciplinary nature and broad societal relevance of this research. The senior authors on this study include Ana Jaklenec and renowned biomedical engineer Robert Langer, both affiliated with MIT’s Koch Institute for Integrative Cancer Research, whose labs have extensively contributed to nutrient encapsulation strategies in recent years. Postdoctoral fellow Xin Yang and Dr. Linzixuan (Rhoda) Zhang PhD ’24 are credited as lead authors, highlighting the collaborative effort across scientific generations.
Future research will likely focus on large-scale human trials to conclusively assess the efficacy, safety, and sensory acceptability of NuMOF-fortified foods. As this platform is refined and commercialized, it could revolutionize nutrition science and public health strategies aimed at addressing micronutrient deficiencies, paving the way for a healthier global population with accessible, fortified food and beverages embedded seamlessly into daily life.
Subject of Research: Nutritional fortification using metal-organic frameworks.
Article Title: Ferrous Nutritional Metal Organic Framework (NuMOF) as Food Fortificant
News Publication Date: 13-Aug-2025
Web References:
DOI: 10.1016/j.matt.2025.102372
Keywords
Nutrition, Nutrients, Nutritional physiology, Malnutrition, Nutrition disorders, Iron deficiency, Foods, Food science, Chemical engineering
