Wednesday, October 29, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Cancer

Former Scripps Research Assistant Professor Honored with 2025 Nobel Prize in Physiology or Medicine

October 7, 2025
in Cancer
Reading Time: 2 mins read
0
65
SHARES
595
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT

In a monumental stride for immunology and medical science, Shimon Sakaguchi, former assistant professor at Scripps Research, has been honored with the 2025 Nobel Prize in Physiology or Medicine. This esteemed recognition applauds Sakaguchi’s pioneering elucidation of peripheral immune tolerance, a vital immunological mechanism pivotal in preventing autoimmune diseases and explicating the multifaceted ways cancer evades immune surveillance. This groundbreaking discovery is not merely a triumph of basic science but holds profound therapeutic ramifications poised to transform clinical approaches to both autoimmune disorders and oncology.

The award is shared with Mary E. Brunkow of the Institute for Systems Biology and Fred Ramsdell of Sonoma Biotherapeutics, reflecting a collective advancement in our comprehension of immune regulation’s intricate landscape. Their joint contributions have significantly expanded the scientific community’s insight into how immune system homeostasis is maintained, highlighting the complex interplay between immune activation and suppression that safeguards the organism from self-directed damage while mounting effective defenses against pathogens and malignancies.

Sakaguchi’s critical breakthrough came in 1995 during his tenure at the Aichi Cancer Center Research Institute in Japan, shortly after his academic stint at Scripps Research from 1989 to 1991. At a time when prevailing immunological dogma posited that central tolerance was primarily enforced via deletion of autoreactive T cells in the thymus, Sakaguchi challenged this concept by identifying a novel subset of T cells characterized by the constitutive expression of the CD25 surface marker. These regulatory T cells, or Tregs, unveiled a previously unknown dimension of immune regulation operating in the periphery, distinct from central deletion processes.

The experimental foundation of this insight involved elegant mouse models genetically deficient in T cells, into which Sakaguchi reintroduced CD4+ T cells either inclusive or depleted of CD25+ populations. Remarkably, the absence of CD25+ T cells precipitated the onset of severe autoimmune pathology, whereas their presence conferred protection, conclusively demonstrating the critical role of Tregs in maintaining immune equilibrium. This functional demonstration elucidated how Tregs act centrally as “immune checkpoints,” preventing autoreactive effector cells from mounting deleterious attacks on self-antigens.

Sakaguchi’s work revolutionized understanding of the immune system’s checks and balances by showing that immune tolerance is an active, dynamic process. Tregs actively surveil and suppress the activation and

Tags: autoimmune disease preventionbasic science and clinical transformationcancer immune evasion mechanismscollaborative scientific advancementsFred Ramsdell biotherapeuticsimmune activation and suppression dynamicsimmune system homeostasis researchMary E. Brunkow contributionsNobel Prize in Physiology 2025peripheral immune tolerance discoveryShimon Sakaguchi immunology breakthroughtherapeutic implications of immunology
Share26Tweet16
Previous Post

UBC Study Highlights Importance of Monitoring Flood Frequency for Safeguarding B.C. Communities

Next Post

Paderborn Chemists Unveil Innovative Method to Decompose Climate-Harming ‘Laughing Gas’

Related Posts

blank
Cancer

Unlocking Longevity: How a Unique Protein Repairs DNA in Bowhead Whales

October 29, 2025
blank
Cancer

Mayo Clinic Scientists Discover Boosting the Body’s ‘First Responder’ Cells Could Enhance Cancer Immunotherapy

October 29, 2025
blank
Cancer

Enhanced Testing Advances Kidney Cancer Diagnosis

October 29, 2025
blank
Cancer

Improving Pediatric Iodinated Contrast Delivery Worldwide

October 29, 2025
blank
Cancer

Renowned Physician-Scientist Dr. Jonathan D. Licht Appointed Next President and Chief Scientific Officer of Van Andel Institute

October 29, 2025
blank
Cancer

NRG Oncology Expands Leadership Across Ancillary Projects, Brain Tumor, Breast Cancer, and Patient Advocate Committees

October 29, 2025
Next Post
blank

Paderborn Chemists Unveil Innovative Method to Decompose Climate-Harming ‘Laughing Gas’

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27573 shares
    Share 11026 Tweet 6891
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    982 shares
    Share 393 Tweet 246
  • Bee body mass, pathogens and local climate influence heat tolerance

    649 shares
    Share 260 Tweet 162
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    517 shares
    Share 207 Tweet 129
  • Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function

    486 shares
    Share 194 Tweet 122
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Plant Biomass Compounds Offer New Solutions for Weed Control
  • Remote Sensing for Land Use Changes in Arid Ecosystems
  • Unlocking Longevity: How a Unique Protein Repairs DNA in Bowhead Whales
  • Scientists Develop Promising New Drug Candidate to Combat Diabetes

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Blog
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 5,189 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading