Monday, August 4, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Cancer

Fibroblast functionality: a pivotal piece in cancer’s spreading puzzle

August 8, 2024
in Cancer
Reading Time: 5 mins read
0
Roles of CAFs in shaping the lymphatic metastatic landscape.
66
SHARES
596
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT
ADVERTISEMENT

A new study reviews how cancer-associated fibroblasts (CAFs) influence lymph node metastasis. Researchers identified various CAF subsets that interact with the tumor microenvironment, promoting cancer spread. By targeting these specific subsets, new therapeutic strategies can be developed to inhibit metastasis, potentially improving patient outcomes. This breakthrough offers a deeper understanding of CAF heterogeneity and its role in cancer progression, paving the way for more effective cancer treatments.

Lymph node metastasis is a crucial factor in cancer progression, significantly affecting patient prognosis and treatment outcomes. The tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), plays a vital role in this process. CAFs influence the metastatic landscape through interactions with other cells and secretion of signaling molecules. Based on these challenges, it is essential to conduct in-depth research to uncover the molecular mechanisms involving CAFs and develop targeted therapies that can inhibit lymphatic metastasis and improve cancer treatment strategies.

Researchers from Sun Yat-sen Memorial Hospital, publishing a study (DOI: 10.20892/j.issn.2095-3941.2024.0138) in Cancer Biology & Medicine on May 22, 2024, have reviewed the heterogeneity of CAFs and their roles in promoting lymphatic metastasis. This study provides a comprehensive analysis of how different CAF subsets interact with the tumor microenvironment, offering new strategies for targeted cancer therapies.

This study highlights the crucial role of CAFs in shaping the lymphatic metastatic landscape. Researchers reviewed various CAF subsets that interact with other stromal cells, secrete cytokines, and produce exosomes, all of which contribute to lymphatic invasion and metastasis. One significant finding is the role of PDGFRα+ITGA11+ CAFs in bladder cancer, which directly interact with lymphatic endothelial cells, enhancing lymphovascular invasion and metastasis. The study also explores the therapeutic potential of targeting specific CAF subsets, showing promising results in preclinical models. By inhibiting the interactions between CAFs and other cells, particularly through targeted antibodies, researchers demonstrated a reduction in lymphatic metastasis. These findings offer valuable insights into the complex mechanisms of CAF-mediated metastasis and suggest new avenues for developing targeted cancer therapies.

Dr. Changhao Chen, a lead researcher, stated, “Our findings underscore the complexity and significance of CAF heterogeneity in cancer progression. By targeting specific CAF subsets, we can develop more effective therapeutic strategies to inhibit lymphatic metastasis and improve patient outcomes.”

The insights from this study pave the way for developing novel cancer therapies that specifically target CAFs. By understanding the diverse roles of CAFs in tumor metastasis, researchers can design targeted treatments that potentially reduce the spread of cancer and enhance the efficacy of existing therapies. This approach could lead to improved prognoses and quality of life for cancer patients.

Roles of CAFs in shaping the lymphatic metastatic landscape.

Credit: Cancer Biology & Medicine

A new study reviews how cancer-associated fibroblasts (CAFs) influence lymph node metastasis. Researchers identified various CAF subsets that interact with the tumor microenvironment, promoting cancer spread. By targeting these specific subsets, new therapeutic strategies can be developed to inhibit metastasis, potentially improving patient outcomes. This breakthrough offers a deeper understanding of CAF heterogeneity and its role in cancer progression, paving the way for more effective cancer treatments.

Lymph node metastasis is a crucial factor in cancer progression, significantly affecting patient prognosis and treatment outcomes. The tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), plays a vital role in this process. CAFs influence the metastatic landscape through interactions with other cells and secretion of signaling molecules. Based on these challenges, it is essential to conduct in-depth research to uncover the molecular mechanisms involving CAFs and develop targeted therapies that can inhibit lymphatic metastasis and improve cancer treatment strategies.

Researchers from Sun Yat-sen Memorial Hospital, publishing a study (DOI: 10.20892/j.issn.2095-3941.2024.0138) in Cancer Biology & Medicine on May 22, 2024, have reviewed the heterogeneity of CAFs and their roles in promoting lymphatic metastasis. This study provides a comprehensive analysis of how different CAF subsets interact with the tumor microenvironment, offering new strategies for targeted cancer therapies.

This study highlights the crucial role of CAFs in shaping the lymphatic metastatic landscape. Researchers reviewed various CAF subsets that interact with other stromal cells, secrete cytokines, and produce exosomes, all of which contribute to lymphatic invasion and metastasis. One significant finding is the role of PDGFRα+ITGA11+ CAFs in bladder cancer, which directly interact with lymphatic endothelial cells, enhancing lymphovascular invasion and metastasis. The study also explores the therapeutic potential of targeting specific CAF subsets, showing promising results in preclinical models. By inhibiting the interactions between CAFs and other cells, particularly through targeted antibodies, researchers demonstrated a reduction in lymphatic metastasis. These findings offer valuable insights into the complex mechanisms of CAF-mediated metastasis and suggest new avenues for developing targeted cancer therapies.

Dr. Changhao Chen, a lead researcher, stated, “Our findings underscore the complexity and significance of CAF heterogeneity in cancer progression. By targeting specific CAF subsets, we can develop more effective therapeutic strategies to inhibit lymphatic metastasis and improve patient outcomes.”

The insights from this study pave the way for developing novel cancer therapies that specifically target CAFs. By understanding the diverse roles of CAFs in tumor metastasis, researchers can design targeted treatments that potentially reduce the spread of cancer and enhance the efficacy of existing therapies. This approach could lead to improved prognoses and quality of life for cancer patients.

###

References

DOI

10.20892/j.issn.2095-3941.2024.0138

Original Source URL

Funding information

This work was funded by the National Key Research and Development Program of China (Grant No. 2022YFA1305500), the National Natural Science Foundation of China (Grant Nos. 32322023, 82173272, 81825016, and 82173230), the Key Areas Research and Development Program of Guangdong (Grant Nos. 2022B1515120086 and 2022A1515140175), and the Science and Technology Program of Guangzhou, China (Grant No. 2023A04J2206).

About Cancer Biology & Medicine

Cancer Biology & Medicine (CBM) is a peer-reviewed open-access journal sponsored by China Anti-cancer Association (CACA) and Tianjin Medical University Cancer Institute & Hospital. The journal monthly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China. The journal is indexed in SCOPUS, MEDLINE and SCI (IF 5.6, 5 year IF 5.9), with all full texts freely visible to clinicians and researchers all over the world (http://www.ncbi.nlm.nih.gov/pmc/journals/2000/).



Journal

Cancer Biology & Medicine

DOI

10.20892/j.issn.2095-3941.2024.0138

Subject of Research

Not applicable

Article Title

Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape: new insights and therapeutic strategies

Article Publication Date

22-May-2024

COI Statement

The authors declare that they have no competing interests.

Share26Tweet17
Previous Post

Smooth sailing for eggplant: breakthrough in understanding prickle formation

Next Post

Millions of years for plants to recover from global warming

Related Posts

blank
Cancer

University of Bath Innovates Breakthrough Technology to Replace Injections with Pills

August 4, 2025
blank
Cancer

Breast Cancer Survival Trends in Ethiopia Revealed

August 4, 2025
blank
Cancer

Small RNA Fragments Hold Major Promise in Advancing Cancer Treatment

August 4, 2025
blank
Cancer

Survival Comparison: HER2+ Pregnancy vs. Non-Pregnancy Breast Cancer

August 4, 2025
blank
Cancer

Advancing Tumor Immunotherapy: The Role of Spatial and Single-Cell Omics in Biomarker Discovery

August 4, 2025
blank
Cancer

Nutritional Status in Chemotherapy Patients: Gaza Study

August 4, 2025
Next Post
Millions of years for plants to recover from global warming

Millions of years for plants to recover from global warming

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27529 shares
    Share 11008 Tweet 6880
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    939 shares
    Share 376 Tweet 235
  • Bee body mass, pathogens and local climate influence heat tolerance

    640 shares
    Share 256 Tweet 160
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    506 shares
    Share 202 Tweet 127
  • Warm seawater speeding up melting of ‘Doomsday Glacier,’ scientists warn

    310 shares
    Share 124 Tweet 78
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Alpha-Synuclein Levels Unnecessary for Parkinson’s Pathology
  • Green Populism: Europe’s Environmental Politics Shift
  • Toxicity of Micro- and Nanoplastics in Lung Cells
  • Breakthrough in Genome Editing: Scientists Attain Megabase-Scale Precision in Eukaryotic Cells

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 5,184 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading