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Cyclin D1 expression in penile cancer

May 15, 2024
in Mathematics
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“Brazil holds the global record for penile cancer incidence.”

Figure 1

Credit: 2024 Duarte et al.

“Brazil holds the global record for penile cancer incidence.”

BUFFALO, NY- May 15, 2024 – A new research paper was published in Oncotarget’s Volume 15 on May 14, 2024, entitled, “Cyclin D1 expression in penile cancer.”

In this new study, researchers Wesliany Everton Duarte, Jaqueline Diniz Pinho, Syomara Pereira da Costa Melo, Denner Rodrigo Diniz Duarte, Juliana Martins da Guia Ribeiro do Carmo, André Salim Khayat, José Ribamar Rodrigues Calixto, Marcos Adriano Garcia Campos, Rita da Graça Carvalhal Frazão Correa, Antonio Machado Alencar Júnior, Antônio Augusto Lima Teixeira-Júnior, and Gyl Eanes Barros Silva from Federal University of Maranhão, State University of Maranhão, Federal University of Pará, São Paulo State University, and University of São Paulo analyzed the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. 

“Regarding PC, however, few studies have assessed the role of cyclin D1, reinforcing the necessity for initiatives that aim to investigate its actual role in the pathophysiology of this disease. As such, the present study aimed to characterize the expression of cyclin D1 in patients with PC, and to determine possible correlations with the clinical and histopathological features of the disease.”

A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017. A review of clinical, epidemiological, and histopathological data was performed, Human Papillomavírus (HPV) DNA was detected using polymerase chain reaction (PCR) and cyclin D1 expression analysis was performed using immunohistochemical techniques. The data revealed that the absence of cyclin D1 expression was significantly associated with HPV-positive histological subtypes (p = 0.001), while its expression was associated with high-grade tumors (p = 0.014), histological subtype (p = 0.001), presence of sarcomatoid transformation (p = 0.04), and perineural invasion (p = 0.023). Patients with cyclin D1 expression exhibited lower disease-free survival compared to the cyclin D1-negative group, although the difference was not statistically significant. 

“The results suggest that cyclin D1 may be a potential biomarker for PC, especially for poorer prognosis.”
 

Continue reading: DOI: https://doi.org/10.18632/oncotarget.28584 

Correspondence to: Gyl Eanes Barros Silva

Email: gyl.silva@ufma.br 

Keywords: immunohistochemistry, biomarkers, cyclin D1, penile neoplasms

Click here to sign up for free Altmetric alerts about this article.
 

About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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For media inquiries, please contact media@impactjournals.com.

 

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###



Journal

Oncotarget

DOI

10.18632/oncotarget.28584

Method of Research

Observational study

Subject of Research

People

Article Title

Cyclin D1 expression in penile cancer

Article Publication Date

14-May-2024

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