Thursday, October 2, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Medicine

CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer

May 29, 2024
in Medicine
Reading Time: 2 mins read
0
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer
66
SHARES
603
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT

NSCLC is the leading cause of cancer deaths globally, with EGFR mutations being a common feature in these cancers. Osimertinib has shown significant improvements in progression-free survival for patients with EGFR mutations. However, the median progression-free survival with osimertinib is still less than 2 years, indicating a need for combination therapies to enhance its efficacy.

CD47 is a transmembrane protein that acts as a “don’t eat me” signal to macrophages, preventing phagocytosis of cancer cells. Many cancers upregulate CD47 to evade immune surveillance. The study found that osimertinib treatment upregulated CD47 expression in EGFR mutant cancer cells, suggesting a potential strategy to improve osimertinib’s efficacy by blocking CD47.

Wei-Bang Yu et al., at State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China, conducted a study that focused on the role of CD47 in non-small cell lung cancer (NSCLC) and its interaction with osimertinib, a third-generation EGFR tyrosine kinase inhibitor (EGFR-TKI).

The study used various reagents, cell lines, and animal models to investigate the effects of osimertinib and anti-CD47 antibody on cancer cells. Techniques such as flow cytometry, Western blot, and quantitative real-time PCR were employed to measure CD47 expression and macrophage infiltration.

Osimertinib induced higher CD47 expression in certain lung cancer cells, which was found to be EGFR-dependent. The study showed that blocking CD47 with an anti-CD47 antibody (B6H12) enhanced the anticancer effect of osimertinib both in vitro and in vivo. Osimertinib also induced stronger antibody-dependent cellular phagocytosis (ADCP) of anti-CD47 antibody in lung cancer cells. The combination of osimertinib and anti-CD47 antibody led to a significant increase in phagocytosis and a better anticancer effect in a mouse xenograft model.

The study suggests that combining osimertinib with CD47 blockade could be a promising strategy to improve outcomes in EGFR mutant NSCLC. The findings also indicate that CD47 upregulation might play a role in resistance to osimertinib, although further research is needed to confirm this.

The research found that osimertinib upregulates CD47 expression via the NF-κB pathway and that the combination of osimertinib with an anti-CD47 antibody significantly promotes phagocytosis and enhances the anticancer effect, offering a potential new combination strategy for EGFR mutant NSCLC.

This research provides valuable insights into the potential for immunotherapy combined with targeted therapy in the treatment of NSCLC, highlighting the importance of understanding the complex interactions between cancer cells and the immune system.

Share26Tweet17
Previous Post

Research to uncover the impact of water use in the Colorado River Basin

Next Post

Impact unveiled: how China’s massive water transfer shapes drinking water quality

Related Posts

blank
Medicine

Tracking Vitamin D Level Changes Amid COVID-19 Pandemic

October 2, 2025
blank
Medicine

Sure! Here’s a rewritten version of the headline tailored for a science magazine post about Bronchiectasis and NTM Research Registry data presented at the European Respiratory Society Congress:

“New Insights into Bronchiectasis and NTM Infections Unveiled from Research Registry Data at European Respiratory Society Congress”

If you want, I can also help rewrite the two abstracts themselves or create a more detailed magazine-style summary based on them. Just let me know!

October 2, 2025
blank
Medicine

Platelet Activation Drives Inflammation in Myasthenia Gravis

October 2, 2025
blank
Medicine

Multimedia Measurements Reveal PFAS Exposure at Home

October 2, 2025
blank
Medicine

The RESTART Trial Explores Drug Targeting Toxic HIV Protein

October 2, 2025
blank
Medicine

Student Nurses’ Realities During Practical Exams in Ghana

October 2, 2025
Next Post
Impact unveiled: how China's massive water transfer shapes drinking water quality

Impact unveiled: how China's massive water transfer shapes drinking water quality

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27561 shares
    Share 11021 Tweet 6888
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    970 shares
    Share 388 Tweet 243
  • Bee body mass, pathogens and local climate influence heat tolerance

    646 shares
    Share 258 Tweet 162
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    513 shares
    Share 205 Tweet 128
  • Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function

    477 shares
    Share 191 Tweet 119
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Tracking Vitamin D Level Changes Amid COVID-19 Pandemic
  • Dynamic Nomogram Predicts Brain Metastasis in NSCLC
  • Volcanic Ash Could Boost Phytoplankton Growth Over 100 km Offshore
  • Global Schizophrenia Trends and Inequalities Forecasted

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Blog
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 5,186 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading