Science News
Structure-alignment-driven cross-graph modeling for functional RNA design
RNAs are critical for biological processes, and their functions are closely tied to their three-dimensional structures. The design of RNA...
Reusability report: Exploring the utility and extensibility of an integrated modelling framework for liquid electrolyte design
Despite rapid advances in machine learning-driven electrolyte design, the robustness, transferability and applicability of existing models remain insufficiently explored. Yang...
Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments
Leng, F. Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments. Nat Protoc (2026). https://doi.org/10.1038/s41596-026-01423-0 https://doi.org/10.1038/s41596-026-01423-0
Sulfated polysaccharides target RANK Lys97 to inhibit osteoclast differentiation and reverse osteoporosis
Current osteoporosis treatments fail to balance bone resorption and formation. Here we show that engineered 2-N,6-O-sulfated chitosan (26SCS), a synthetic...
Regulation of RNA transcript elongation in metazoans and its relevance to disease
Our understanding of transcript elongation by metazoan RNA polymerase II (Pol II) has grown notably in recent years. Advances in...
Expanding the repertoire of chemically induced covalent neoantigens
The ubiquitin–proteasome system generates peptide fragments that are displayed on class I major histocompatibility complex molecules. Hapten-modified peptides, or covalent...
Age- and sex-dependent associations of metabolic syndrome with colorectal cancer in the UK Biobank
Luo, Z., Safizadeh, F., Mandic, M. et al. Age- and sex-dependent associations of metabolic syndrome with colorectal cancer in the...
Researchers develop low-noise magnetic sensor with enhanced weak-field detection
Researchers from the High Magnetic Field Laboratory of the Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), together...
Nanosecond proton FLASH radiotherapy reduces normal cell damage
A research team led by Prof. HUANG Qing from the Hefei Institutes of Physical Science of the Chinese Academy of...
Crystallization engineering enhances high-frequency performance of thick carbon electrodes
A research team led by Prof. MENG Guowen and Prof. HAN Fangming from the Institute of Solid State Physics, Hefei...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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