Thursday, August 7, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Chemistry

Breakthrough in molecular control: new bioinspired double helix with switchable chirality

August 8, 2024
in Chemistry
Reading Time: 5 mins read
0
Double-helical mononmetallofoldamers with inverse helicity
65
SHARES
592
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT
ADVERTISEMENT

The deoxyribonucleic acid or DNA, the molecular system that carries the genetic information of living organisms, can transcribe and amplify information using its two helical strands. Creating such artificial molecular systems that match or surpass DNA in functionality is of great interest to scientists. Double-helical foldamers are one such molecular system.

Double-helical mononmetallofoldamers with inverse helicity

Credit: Hidetoshi Kawai from Tokyo University of Science

The deoxyribonucleic acid or DNA, the molecular system that carries the genetic information of living organisms, can transcribe and amplify information using its two helical strands. Creating such artificial molecular systems that match or surpass DNA in functionality is of great interest to scientists. Double-helical foldamers are one such molecular system.

 

Helical foldamers are a class of artificial molecules that fold into well-defined helical structures like helices found in proteins and nucleic acids. They have garnered considerable attention as stimuli-responsive switchable molecules, tuneable chiral materials, and cooperative supramolecular systems due to their chiral and conformational switching properties. Double-helical foldamers exhibit not only even stronger chiral properties but also  unique properties, such as the transcription of chiral information from one chiral strand to another without chiral properties, enabling potential applications in higher-order structural control related to replication, like nucleic acids. However, the artificial control of the chiral switching properties of such artificial molecules remains challenging due to the difficulty in balancing the dynamic properties required for switching and stability. Although various helical molecules have been developed in the past, reversal of twist direction in double-helix molecules and supramolecules has rarely been reported.

 

In a breakthrough, a team of researchers from Tokyo University of Science, Japan, led by Professor Hidetoshi Kawai from the Department of Chemistry, Faculty of Science, and including Mr. Kotaro Matsumura from the Department of Chemistry, developed a novel mechanical motif, called double-helical monometallofoldamers with controllable chiral switching. Prof. Kawai explains, “In this research, we succeeded in synthesizing a double helical mononuclear complex bridged with a single metal cation in the center of the helices to balance both stability and dynamic properties. These structures can undergo inversion switching by changing the left and right winding directions of both helix strands using different solvents.” Their study was published in the Journal of the American Chemical Society on July 19, 2024.

 

The researchers synthesized the double-helical monometallofoldamers from two bipyridine-type strands with L-shaped units, which after forming a complex with a zinc cation formed double-helical structures. X-ray crystallography revealed the double-helical structures with a metal cation in their center. The researchers investigated the switchability of monometallofoldamers in response to external stimuli and found that helix terminals of the double-helical form can unfold in solutions, resulting in the open form, favored at high temperatures, and refold to the double-helical form, favored at low temperatures.

 

Interestingly, the helicity of the double-helical monometallofoldamer with chiral chains can be controlled in response to achiral solvents. For example, in non-polar solvents (toluene, hexane, Et2O), it becomes left-handed or M-form, and in Lewis basic solvents (acetone, DMSO), it becomes right-handed or the P-form. The conformation of chiral chains introduced into the helix strands was found to be important for this M/P switching. Furthermore, they found that when a helix strand with chiral chains is mixed with a strand without chiral chains, the winding direction of the helix is transmitted and amplified to the achiral strand without chiral chains, with the helicity inversion ability maintained.

 

Emphasizing the significance of this new molecule, Mr. Matsumura says, “Our synthesized double-helical monometallofoldamers has the potential to be applied to new switching chiral materials that output diverse chiral properties by small inputs and can be used to develop chiral sensors. In addition, we expect that this novel molecular structure will lead to facilitate the genesis of deracemized and organized supramolecular systems as those found in nature by transmitting and amplifying their superior chiral properties.”

 

Overall, this study marks a significant step towards realizing artificial controllable double-helical structures, paving the way for novel high-order molecular systems and molecular information processing.

 

***

 

Reference                     

DOI: 10.1021/jacs.4c06560

 

About The Tokyo University of Science

Tokyo University of Science (TUS) is a well-known and respected university, and the largest science-specialized private research university in Japan, with four campuses in central Tokyo and its suburbs and in Hokkaido. Established in 1881, the university has continually contributed to Japan’s development in science through inculcating the love for science in researchers, technicians, and educators.

With a mission of “Creating science and technology for the harmonious development of nature, human beings, and society,” TUS has undertaken a wide range of research from basic to applied science. TUS has embraced a multidisciplinary approach to research and undertaken intensive study in some of today’s most vital fields. TUS is a meritocracy where the best in science is recognized and nurtured. It is the only private university in Japan that has produced a Nobel Prize winner and the only private university in Asia to produce Nobel Prize winners within the natural sciences field.

Website:

 

About Professor Hidetoshi Kawai from Tokyo University of Science

Hidetoshi Kawai is currently a Professor at the Department of Chemistry, Faculty of Science at Tokyo University of Science. He obtained his Ph.D. from Hokkaido University in 2000. He has over 130 publications with over 2500 citations. At Tokyo University of Science, he also leads the Kawai lab. Additionally, he served as a guest lecturer at the Université de Strasbourg, France in 2016. His research interests include supramolecular chemistry, structural organic chemistry, high-efficiency molecular conversion, and self-amplifying molecules among others.

 

Funding information

This work was supported by the JSPS KAKENHI (Grant 461 Numbers JP20K05478 and JP24K08385 for H.K. and 462 JP16J08668 for K. T.) and JST SPRING (Grant Number 463 JPMJSP2151 for K. M.).



Journal

Journal of the American Chemical Society

DOI

10.1021/jacs.4c06560

Method of Research

Experimental study

Subject of Research

Not applicable

Article Title

M/P Helicity Switching and Chiral Amplification in Double-Helical Monometallofoldamers

Article Publication Date

19-Jul-2024

COI Statement

The authors declare no competing financial interest.

Share26Tweet16
Previous Post

Detecting climate change using aerosols

Next Post

Exploring the impact of attentional uniqueness and attentional allocation on firm growth

Related Posts

blank
Chemistry

Invisible Material Poised to Transform Smart Technology

August 7, 2025
blank
Chemistry

Room-Temperature Quantum Freezing Achieved

August 7, 2025
blank
Chemistry

Researchers at Columbia Highlight the Importance of Chemistry in Quantum Materials

August 7, 2025
blank
Chemistry

Immobilized Reactors Revolutionize Sterically Hindered Peptide Synthesis

August 7, 2025
blank
Chemistry

Scientists Develop Technique to Halt Ultrafast Silicon Melting with Precision Laser Pulses

August 7, 2025
blank
Chemistry

Breakthrough in Green Chemistry: Efficient Low-Temperature Oxidation Makes Processes Cleaner, Cooler, and More Affordable

August 7, 2025
Next Post
How Unique Attention Patterns Drive Success

Exploring the impact of attentional uniqueness and attentional allocation on firm growth

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27530 shares
    Share 11009 Tweet 6881
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    942 shares
    Share 377 Tweet 236
  • Bee body mass, pathogens and local climate influence heat tolerance

    641 shares
    Share 256 Tweet 160
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    506 shares
    Share 202 Tweet 127
  • Warm seawater speeding up melting of ‘Doomsday Glacier,’ scientists warn

    310 shares
    Share 124 Tweet 78
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Mapping SeGPx in S. digitata Genome and Extract
  • Enzyme-Responsive Packaging Revolutionizes Food Preservation
  • Youth and OTC CBD Use: Spain’s Current Landscape
  • Ilimaquinone: A Novel Antibacterial Agent from Marine Sponges

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 4,859 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading