E3 Ligase UBE4B Tags VPS35 for Destruction, Steering Cancer Cell Behavior in Context-Dependent Ways
A new study shows the E3 ligase UBE4B ubiquitinates and degrades VPS35, with opposing effects on cancer cell proliferation and...
Stage, EGFR Status and CEA Predict Brain Metastasis Risk in Lung Cancer
A retrospective Chinese cohort study found that advanced T stage, nodal involvement, EGFR mutation, and elevated serum CEA were associated...
Most Swedish cancer survivors use primary care, but satisfaction varies widely between groups
A Swedish cross-sectional survey of people with breast, prostate, lung, or colorectal cancer found that almost all had used primary...
EGFR-IL-8 Feedback Loop Drives Lenvatinib Resistance in Liver Cancer Cells
A new cell-culture study reports that an EGFR-IL-8 signaling loop between liver cancer cells and macrophages sustains lenvatinib resistance in...
New Ex Vivo Co-Culture Method Grows Breast Cancer Cells Inside Living Mouse Bone
Researchers have developed a protocol that keeps mouse bone and marrow alive in a dish for up to four weeks...
Phase-contrast breast CT wins over radiologists in blinded reader study
In a blinded reader study of five fresh tumourectomy specimens, radiologists rated fused grating-interferometry breast CT images significantly higher than...
PET/CT-first staging proposed for anal cancer, with MRI reserved for selected cases
A narrative review proposes that FDG PET/CT could serve as the first staging investigation for most anal cancer patients, with...
Silymarin Shows Modest Liver-Protective Effects in Chemotherapy Patients, Meta-Analysis Finds
A meta-analysis of six randomized trials found silymarin significantly lowered AST and ALT in chemotherapy patients, with no significant effect...
Early first birth may offset breast cancer risk tied to early periods in UK Biobank study
An analysis of 254,578 UK Biobank women found that a first live birth by age 30 was associated with a...
Blood CXCL1 tracks Salmonella colonization in tumors, study finds
Sustained blood CXCL1 elevation tracked attenuated Salmonella colonization in four preclinical tumor models.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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