Culture Medium Rewrites Drug Sensitivity in Patient-Derived Tumor Organoids
A new study shows that the choice between Wnt-based and OncoPro culture medium reshapes the transcriptional state and drug sensitivity...
Tumor acidity emerges as a metabolic barrier blocking cancer immunotherapy
A narrative review argues that the acidic tumor microenvironment suppresses antitumor immunity and that targeting acidity is a preclinically supported...
Rare leukemia revealed by diffuse osteosclerosis on FDG-PET/CT
An FDG-PET/CT scan in a 64-year-old woman with fever of unknown origin revealed diffuse osteosclerosis and osteolytic lesions that led...
PD-L1-Targeted Lutetium-177 Radiotherapy Shrinks Triple-Negative Breast Tumors in Mice
Radiolabeled atezolizumab with lutetium-177 significantly reduced tumor volumes and extended median survival in a mouse model of triple-negative breast cancer.
Oral IDH1 Inhibitor Ivosidenib Holds Rare Liver Cancer at Bay for 35 Months in Case Report
A case report documents 35 months of oral ivosidenib therapy with partial remission and no adverse events in a man...
Rare Ovarian Sertoli-Leydig Cell Tumor Mistaken for Leiomyosarcoma in 45-Year-Old Woman
A case report describes a rare poorly differentiated ovarian Sertoli-Leydig cell tumor with smooth muscle differentiation that was initially misdiagnosed...
Research report: NLRC4 Acts as a Non‐Canonical Tumour Suppressor in Lung Adenocarcinoma by Inhibiting PI3K/AKT/mTOR Signalling to Induce Protective Autophagy
A new study shows that the immune sensor NLRC4 acts as a tumour suppressor in lung adenocarcinoma by restoring PTEN...
Single-center cohort maps real-world treatment sequencing in ovarian carcinosarcoma
A retrospective single-center cohort of 44 patients with ovarian carcinosarcoma documents predominantly platinum-taxane first-line therapy, limited confirmed later-line treatment, and...
E3 Ligase TRIP12 Drives Protein Synthesis and Tumour Growth Through mTOR Pathway
A new cell-line study reports that the E3 ubiquitin ligase TRIP12 promotes protein translation and tumour-like growth in human cancer...
Two Decades of Data Reveal How Nanoformulated Tocotrienol Research Went Global
A new bibliometric analysis of 360 publications from 1999 to 2025 maps the growth, leading countries, top journals and five...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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