Nucleosomes and IDRs Restrain GCN4’s Promiscuous Binding on Minichromosomes
A new study is reshaping the way scientists understand how transcription factors find their targets inside the crowded genome. Researchers...
Spatial transcriptomics reveals dynamic cellular programs driving human heart transplant rejection
A heart transplant can restore circulation, reverse advanced heart failure and give patients years of life, but the new organ...
Study reveals how PRC2 guides preimplantation development and primordial germ cell fate
A new study has revealed that the epigenetic regulator PRC2 performs different, stage-specific jobs during the earliest phases of mammalian...
Brain mega-enhancers compartmentalize transcriptionally active long genes
A previously unrecognized layer of genome organization has been identified in the mammalian brain, where exceptionally long genes and the...
hnRNPK condensates boost enhancer–promoter looping and RNA polymerase II recruitment
Scientists have identified a molecular organizer that helps connect distant regulatory regions of the genome with the genes they control,...
Epigenetic changes in stromal cells drive disease-promoting tissue niches in Crohn’s disease
Crohn’s disease is often described as an immune disorder, but a new study suggests that the cells forming the body’s...
Giant Sunflower Family Genome Assembly Opens Path to New Perennial Crops
A pair of prairie plants with roots deep enough to reach several meters into the soil has moved closer to...
Study estimates glutamate and GABA genes’ distinct causal effects in autism
Autism research has long wrestled with a deceptively simple question: when genetic differences are linked to brain development and behavior,...
RAS Rewires Ribosomes, Reshaping How Cells Read the Genetic Code
Cancer cells may be able to reprogram more than gene activity and signaling networks. A study led by researchers at...
Genomic analysis reveals how SARS-CoV-2 entered and spread across Georgia
The movement of SARS-CoV-2 across borders and through communities has left a genetic record in the virus’s genome. A study...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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