About The Study: There were similar and, in some instances, more favorable neonatal and maternal outcomes for pregnancies exposed to buprenorphine combined with naloxone compared with buprenorphine alone. For the outcomes assessed, compared with buprenorphine alone, buprenorphine with naloxone during pregnancy appears to be a safe treatment option. This supports the view that both formulations are reasonable options for the treatment of opioid use disorder in pregnancy, affirming flexibility in collaborative treatment decision-making.
About The Study: There were similar and, in some instances, more favorable neonatal and maternal outcomes for pregnancies exposed to buprenorphine combined with naloxone compared with buprenorphine alone. For the outcomes assessed, compared with buprenorphine alone, buprenorphine with naloxone during pregnancy appears to be a safe treatment option. This supports the view that both formulations are reasonable options for the treatment of opioid use disorder in pregnancy, affirming flexibility in collaborative treatment decision-making.
Corresponding Author: To contact the corresponding author, Loreen Straub, MD, MS, email lstraub@bwh.harvard.edu.
To access the embargoed study: Visit our For The Media website at this link
(doi:10.1001/jama.2024.11501)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Cite Scienmag News
Ophelia Keating. (August 12, 2024). Comparative safety of in utero exposure to buprenorphine combined with naloxone vs buprenorphine alone. Scienmag. https://scienmag.com/comparative-safety-of-in-utero-exposure-to-buprenorphine-combined-with-naloxone-vs-buprenorphine-alone/
Ophelia Keating. "Comparative safety of in utero exposure to buprenorphine combined with naloxone vs buprenorphine alone." Scienmag, 12 August 2024, https://scienmag.com/comparative-safety-of-in-utero-exposure-to-buprenorphine-combined-with-naloxone-vs-buprenorphine-alone/. Accessed 4 September 2026.
Ophelia Keating. "Comparative safety of in utero exposure to buprenorphine combined with naloxone vs buprenorphine alone." Scienmag. August 12, 2024. https://scienmag.com/comparative-safety-of-in-utero-exposure-to-buprenorphine-combined-with-naloxone-vs-buprenorphine-alone/
