Working night shifts unlikely to increase breast cancer risk
NEW RESEARCH* has found that working night shifts has little or no effect on a woman's breast cancer risk despite a review in 2007 by the International Agency for Research on Cancer (IARC) classifying shift work disrupting the 'body clock' as a probable cause of cancer.
At the time of the 2007 classification there was limited evidence about breast cancer risk in humans so the classification was mainly based on a combination of animal and lab studies.
The new research, published in the Journal of the National Cancer Institute today (Thursday) and funded by the UK Health and Safety Executive, Cancer Research UK and the UK Medical Research Council, examined whether night shift work increased women's breast cancer risk by following 1.4 million women in ten studies and seeing if they developed breast cancer.
It combined new results from three large studies, studying 800,000 women from the Million Women Study, EPIC-Oxford and UK Biobank cohorts, with data from seven already published studies from the USA, China, Sweden and the Netherlands.
Compared with women who had never worked night shifts, those who had ever done night work – including those who had worked nights for 20 or 30 years – had no increased risk of breast cancer.
Dr Ruth Travis, lead author and a Cancer Research UK-funded scientist at the Cancer Epidemiology Unit at the University of Oxford, said: "We found that women who had worked night shifts, including long-term night shifts, were not more likely to develop breast cancer, either in the three new UK studies or when we combined results from all 10 studies that had published relevant data."
The researchers found that the incidence of breast cancer was essentially the same whether someone did no night shift work at all or did night shift work for several decades – the combined relative risks taking all 10 studies together were 0.99 for any night shift work, 1.01 for 20 or more years of night shift work, and 1.00 for 30 or more years night shift work.
On average one in seven (14 per cent) women in the UK have ever worked nights and one in 50 (two per cent) have worked nights for 20 or more years.
Each year in the UK around 53,300 women are diagnosed with breast cancer and around 11,500 die from the disease.
Professor Andrew Curran, chief scientific adviser for the the HSE, which commissioned the study, said: "Breast cancer is the most common cancer in women so it was vital for us to fund work in this area to establish if there is a link to night work.
"In Great Britain, there are 2 million women, about one in six female workers, who are currently working in some types of shift work, and over half million of them are working in shifts that involves night work.
"This study has shown that night shift work, including long-term shift work, has little or no effect on breast cancer incidence in women. However, there are a number of other known risks with shift work that employers must take into consideration when protecting their workers' health and safety."
Professor Cathie Sudlow, chief scientist at the UK Biobank, said: "The work demonstrates the power of very large, well-designed studies to answer important questions where previous evidence has been unclear. This study is also a landmark for UK Biobank, since it is the first time that associations between potential risk factors (in this case working nights) and new cases of cancer developing during follow-up, have been published using UK Biobank data. We expect many further findings to emerge from UK Biobank alone as well as from combining its data with other major studies, such as the Million Women Study and EPIC. Collaborative efforts like this will advance our understanding of a wide range of diseases more quickly and help find new ways to prevent and treat them."
Sarah Williams, Cancer Research UK's health information manager, said: "This study is the largest of its kind and has found no link between breast cancer and working night shifts. Research over the past years suggesting there was a link has made big headlines, and we hope that today's news reassures women who work night shifts.
"Breast cancer is the most common cancer in the UK and research to fully understand the different risk factors is vital so that we can give women clear health advice. Women can reduce their risk of breast cancer by keeping a healthy weight, drinking less alcohol and being active."
For media enquiries contact Emily Head in the Cancer Research UK press office on 020 3469 6189 or, out of hours, on 07050 264 059.
Notes to editor:
* Travis et al. Night shift work and breast cancer incidence: three prospective studies and meta-analysis of published studies. JNCI (2016). doi: 10.1093/jnci/djw169
More information about the EPIC study here: http://epic.iarc.fr/ and the Million Women study here: http://www.millionwomenstudy.org/introduction/
About the Medical Research Council
The Medical Research Council is at the forefront of scientific discovery to improve human health. Founded in 1913 to tackle tuberculosis, the MRC now invests taxpayers' money in some of the best medical research in the world across every area of health. Thirty-one MRC-funded researchers have won Nobel prizes in a wide range of disciplines, and MRC scientists have been behind such diverse discoveries as vitamins, the structure of DNA and the link between smoking and cancer, as well as achievements such as pioneering the use of randomised controlled trials, the invention of MRI scanning, and the development of a group of antibodies used in the making of some of the most successful drugs ever developed. Today, MRC-funded scientists tackle some of the greatest health problems facing humanity in the 21st century, from the rising tide of chronic diseases associated with ageing to the threats posed by rapidly mutating micro-organisms. http://www.mrc.ac.uk
About the HSE
The Health and Safety Executive (HSE) is Britain's national regulator for workplace health and safety. It aims to reduce work-related death, injury and ill health. It does so through research, information and advice, promoting training; new or revised regulations and codes of practice, and working with local authority partners by inspection, investigation and enforcement. http://www.hse.gov.uk
About Cancer Research UK
- Cancer Research UK is the world's leading cancer charity dedicated to saving lives through research.
- Cancer Research UK's pioneering work into the prevention, diagnosis and treatment of cancer has helped save millions of lives.
- Cancer Research UK receives no government funding for its life-saving research. Every step it makes towards beating cancer relies on every pound donated.
- Cancer Research UK has been at the heart of the progress that has already seen survival in the UK double in the last forty years.
- Today, 2 in 4 people survive their cancer for at least 10 years. Cancer Research UK's ambition is to accelerate progress so that by 2034, 3 in 4 people will survive their cancer for at least 10 years.
- Cancer Research UK supports research into all aspects of cancer through the work of over 4,000 scientists, doctors and nurses.
- Together with its partners and supporters, Cancer Research UK's vision is to bring forward the day when all cancers are cured.
For further information about Cancer Research UK's work or to find out how to support the charity, please call 0300 123 1022 or visit http://www.cancerresearchuk.org. Follow us on Twitter and Facebook.