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Home SCIENCE NEWS Medicine & Health

Why aren’t more kids with sickle cell disease getting this test?

October 20, 2017
in Medicine & Health
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Credit: Sarah Pack

Hematologist and researcher Julie Kanter says as few as 30 percent of children across the country with sickle cell disease are getting a simple test that could keep them from having a stroke. She wants to bring that more in line with the MUSC Health rate of around 85 percent.

So Kanter and two other researchers at the Medical University of South Carolina are leading a national, 28-site study, looking at what keeps some children from getting transcranial Doppler exams.

"When I see kids — or adults — not getting the care they're supposed to, that everyone should be giving them, it's very bothersome," Kanter said. The MUSC Health doctor directs sickle cell disease research at MUSC, which recruited her to help make the campus a national leader in fighting a condition that affects an estimated 4,500 people in South Carolina. Kanter also leads a statewide network that's working to improve care throughout the state for teenagers and young adults.

She, stroke specialist Robert Adams and public health expert Cathy Melvin make up the MUSC team leading the national transcranial Doppler study. It's called DISPLACE, or "Dissemination and Implementation of Stroke Prevention Looking at the Care Environment." The National Heart, Lung and Blood Institute is paying $5 million to fund the study over a five-year period.

A transcranial Doppler, or TCD, measures how quickly blood is flowing through vessels in the brain. "Doing the TCD is like a colon cancer screen," Kanter said. "If you do a colonoscopy, you can prevent colon cancer by taking the necessary steps following that colonoscopy. If we do a TCD and it's abnormal, you can start transfusion therapy and prevent stroke."

Strokes are a common concern for people with sickle cell disease. Sickle cells are misshaped red blood cells that don't flow easily in the body. They can clump up in brain arteries, damaging the walls of blood vessels and leading to strokes.

Why doesn't every child with sickle disease get transcranial Doppler screening as often as needed? That's what the study will find out. Kanter already knows some possibilities. "A child may not get a TCD because mom forgot the appointment or didn't think it was important. Maybe the TCD machine was broken or unavailable. We don't know. We only know that about one-third to one-half of kids are getting them the way they're supposed to."

Adams, one of her co-principal investigators on the study, has been involved in research aimed at reducing strokes in kids with sickle cell disease for almost two decades. He led an earlier study that showed TCD is a good screening tool. But Kanter said follow-up research showed not everybody was benefitting from it. "Implementation rates varied between 30 and 70 percent at different institutions."

Once the new study shows what the barriers are, the focus will shift to how to get rid of those barriers and get more people the screening they need.

###

Media Contact

Heather Woolwine
[email protected]
843-792-7669
@MUSChealthPN

http://www.musc.edu

Original Source

http://academicdepartments.musc.edu/newscenter/2017/kanter-sickle-cell-research/

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