Philadelphia, December 22, 2021 – Brain imaging studies have shown structural and functional abnormalities in people with psychosis in the connections between the cortex and the thalamus, the major waystation for incoming sensory information and a critical regulator of cortical activity. A new study shows that those differences are not present during development, but that the integrity of the connections is compromised in youth with psychosis spectrum symptoms.
“This work provides insight into the fundamental changes occurring over development in white matter connections linking the thalamus and cortex, and how developmental patterns differ in youth with psychosis spectrum symptoms at risk for developing a psychotic disorder,” said lead author, Suzanne Avery, PhD, Vanderbilt University Medical Center, Nashville, TN, of the study that appears in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, published by Elsevier.
White matter refers to parts of the brain made up of fatty, myelinated axons, which send information across wide-ranging brain areas. Myelin is generated in non-neuronal glial cells that wrap around neuronal axons as insulation to speed signaling. Disruption in white matter structure has been seen in the brains of people with psychosis and is hypothesized to play a role in cognitive deficits.
For the current study, Dr. Avery and colleagues examined data from 1,144 participants aged 8 to 22 years old; 316 were typically developing whereas the rest had psychosis spectrum symptoms or some other psychopathology.
Dr. Avery said, “Somewhat surprisingly, our findings show that white matter structural tracts are relatively stable throughout typical development and are similar in children at higher risk for psychosis, suggesting the structural deficits we find often detected in psychosis patients may have occurred later, near the onset of illness, or may be limited to only those individuals who will go on to develop a psychotic disorder.”
However, when the authors examined the white matter at a microstructural level, she said, “we found that the microstructural integrity of white matter tracts increases substantially over development, particularly in tracts linking the thalamus to the prefrontal and posterior parietal cortex.” Moreover, structural integrity of these tracts was lower in children exhibiting psychosis spectrum symptoms and was associated with cognitive function.
“This suggests a critical role for abnormal developmental processes, such as deficits in white matter myelination, in the risk for both cognitive deficits and psychosis,” Dr. Avery added. “This work could have implications for the early detection and treatment of children at risk for developing a psychotic illness. Novel therapeutic approaches should target mechanisms that increase myelination, as hypomyelination may increase cognitive deficits and risk for worsening psychosis symptoms.”
Cameron Carter, MD, Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, said, “This important study complements the authors’ previous work on functional connectivity in the thalamocortical tracts in psychosis, mapping out a functional brain anatomy of these serious and distressing symptoms. It also places them in a developmental context and takes us a step closer to understanding the mechanisms underlying serious mental illness and suggests new venues for prevention and treatment.”
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Notes for editors
The article is “Development of thalamocortical structural connectivity in typically developing and psychosis spectrum youth,” by Suzanne Avery, Anna Huang, Julia Sheffield, Baxter Rogers, Simon Vandekar, Alan Anticevic, Neil Woodward (https://doi.org/10.1016/j.bpsc.2021.09.009). It appears as an Article in Press in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, published by Elsevier.
Copies of this paper are available to credentialed journalists upon request; please contact Rhiannon Bugno at BPCNNI@sobp.org or +1 254 522 9700. Journalists wishing to interview the authors may contact Suzanne Avery at suzanne.avery@vumc.org or Neil Woodward at neil.woodward@vumc.org or +1 615 322 8361.
The authors’ affiliations and disclosures of financial and conflicts of interests are available in the article.
Cameron S. Carter, MD, is Professor of Psychiatry and Psychology and Director of the Center for Neuroscience at the University of California, Davis. His disclosures of financial and conflicts of interests are available here.
About Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society of Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The 2020 Impact Factor score for Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is 6.204. www.sobp.org/bpcnni
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Media contact
Rhiannon Bugno, Editorial Office
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
+1 254 522 9700
BPCNNI@sobp.org
Journal
Biological Psychiatry Cognitive Neuroscience and Neuroimaging
DOI
10.1016/j.bpsc.2021.09.009
Method of Research
Imaging analysis
Subject of Research
People
Article Title
Development of thalamocortical structural connectivity in typically developing and psychosis spectrum youth
Article Publication Date
14-Oct-2021
COI Statement
The authors’ affiliations and disclosures of financial and conflicts of interests are available in the article.