Vitamin E and selenium don’t prevent polyps that can lead to colorectal cancer

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PORTLAND, OR – Eight years ago, results from a landmark cancer prevention trial run by SWOG showed that a daily dose of vitamin E and selenium did not prevent prostate cancer. In fact, the Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed that vitamin E supplementation increased the risk of prostate cancer in healthy men.

Now, a SWOG review of ancillary SELECT results definitively shows that these two antioxidants also don't prevent colorectal adenomas – polyps that are the premalignant precursors to most colorectal cancers. Results are published in Cancer Prevention Research.

"The message to the public is this: Vitamin E and selenium will not prevent colorectal adenomas, which are surrogates for colorectal cancer," said Dr. Peter Lance, lead author of the journal article and deputy director of the University of Arizona Cancer Center. "We have no evidence that these supplements work to prevent cancer."

Despite the billions spent in the United States each year on vitamin supplements, there is scant evidence they prevent cancer. According to the National Cancer Institute, which funds SWOG through its National Clinical Trials Network (NCTN) and NCI Community Oncology Research Program (NCORP), results from nine randomized trials did not provide evidence that antioxidant supplements are beneficial in primary cancer prevention. An in-depth review conducted for the United States Preventive Services Task Force likewise found no clear evidence of benefit.

"There's a whole industry that has people dosing themselves thinking that vitamins will keep them healthy," Lance said. "But we have little evidence that they protect against cancer."

To arrive at their conclusions, Lance and his SWOG team used data from SELECT, a prostate cancer prevention trial that enrolled an astonishing 35,533 healthy men – 21 percent men of color – in just 33 months at 427 study sites the United States, Canada, and Puerto Rico. Men were randomized into four groups. Some took a daily dose of vitamin E, others a dose of selenium, others took both antioxidants, and the rest took a placebo only.

A substantial number of SELECT participants incidentally underwent a lower endoscopy – colonoscopy or sigmoidoscopy – as part of their usual clinical care while taking part in the trial. In an ancillary study, Lance and his team went back into the SELECT data to review the lower endoscopy and pathology reports. They were able to evaluate information on 6,546 participants who received the procedure as part of SELECT, and found that 2,286 had more than one polyp detected by cameras used in the procedures. A statistical analysis showed that the occurrence of one or more premalignant polyps was about the same among men, regardless of whether men were taking selenium or vitamin E, alone or together, or double placebo.

What makes these results definitive, Lance said, is that SELECT was so large and was a randomized controlled study – a design that reduces bias and is considered the gold standard in clinical research.

Lance led another University of Arizona Cancer Center team that has just published similar results from a separate randomized trial of selenium and celecoxib. In December 2016, in the Journal of the National Cancer Institute, the team reported that selenium didn't prevent colorectal adenomas – and was associated with increased risk for Type 2 diabetes.

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Lance's SWOG study team includes: Denise Row, Dr.P.H., of the University of Arizona Mel & Enid Zuckerman College of Public Health; Dr. David Alberts, University of Arizona Cancer Center; Patricia Thompson-Carino, Ph.D., of Stony Brook Cancer Center; Liane Fales of University of Arizona Cancer Center; Fang Wang of Stony Brook Cancer Center; Jerilyn San Jose of University of Arizona Cancer Center; Elizabeth Jacobs, Ph.D. of University of Arizona Cancer Center; Phyllis Goodman of the SWOG Statistical Center at Fred Hutchinson Cancer Research Center; Amy Darke of the SWOG Statistical Center at Fred Hutchinson Cancer Research Center; Monica Yee of SWOG Statistical Center at Cancer Research And Biostatistics; Dr. Lori Minasian of the Division of Cancer Prevention at the National Cancer Institute; and Dr. Ian Thompson of the University of Texas Health Sciences Center.

The work was funded by the National Institutes of Health Public Health Service, National Cancer Institute grants RO1 CA124862; U10 CA37429; and UM1 CA182883.

SWOG is part of the National Cancer Institute's National Clinical Trials Network, the nation's oldest and largest cancer research network, and is a major part of the cancer research infrastructure in the U.S. and the world. SWOG has over 12,000 members in 46 states and six foreign countries who design and conduct cancer clinical trials to improve the lives of people with cancer. Founded in 1956, SWOG's 1,300 trials have led to the approval of 14 cancer drugs, changed more than 100 standards of cancer care, and saved more than 2 million years of human life. Learn more at swog.org.

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Wendy Lawton
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@SWOG

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