University of Kent scientists make vitamin B12 breakthrough
Scientists at the University of Kent have made a significant discovery about how the vitamin content of some plants can be improved to make vegetarian and vegan diets more complete.
Vitamin B12 (known as cobalamin) is an essential dietary component but vegetarians are more prone to B12 deficiency as plants neither make nor require this nutrient.
But now a team, led by Professor Martin Warren at the University's School of Biosciences, has proved that common garden cress can indeed take up cobalamin.
The amount of B12 absorbed by garden cress is dependent on the amount present in the growth medium, and the Kent team was able to confirm B12 uptake by showing that the nutrient ends up in the leaf.
The observation that certain plants are able to absorb B12 is important as such nutrient-enriched plants could help overcome dietary limitations in countries such as India, which have a high proportion of vegetarians and may be significant as a way to address the global challenge of providing a nutrient-complete vegetarian diet, a valuable development as the world becomes increasingly meat-free due to population expansion.
The Kent scientists worked with biology teachers and year 11 and 12 pupils at Sir Roger Manwood's School in Sandwich to investigate the detection and measurement of B12 in garden cress.
The pupils grew garden cress containing increasing concentrations of vitamin B12. After seven days growth, the leaves from the seedlings were removed, washed and analysed.
The seedlings were found to absorb cobalamin from the growth medium and to store it in their leaves. To confirm this initial observation, the scientists at Kent then made a type of vitamin B12 that emits fluorescent light when activated by a laser. This fluorescent B12 was fed to the plants and it was found to accumulate within a specialised part of the leaf cell called a vacuole, providing definitive evidence that some plants can absorb and transport cobalamin.
Vitamin B12 is unique among the vitamins because it is made only by certain bacteria and therefore has to undergo a journey to make its way into more complex multi-cellular organisms. The research described in the paper highlights how this journey can be followed using the fluorescent B12 molecules, which can also be used to help understand why some people are more prone to B12-deficiency.
The discovery also has implications for combating some parasitic infections. Not only did the researchers demonstrate that some plants can absorb vitamin B12, they were also able to use the same technique to follow the movement of fluorescent B12 molecules into worms. These results demonstrate that this is a powerful model to learn about how B12 is absorbed and, as worms must use a different absorption system to mammalian systems, there is the possibility of exploiting this difference to try and treat worm-based parasites such as hook worms.
The research is now published in the journal Cell Chemical Biology. Authors at Kent include Andrew Lawrence, Emi-Nemoto-Smith, Evelyne Deery, Joseph Baker, Susanne Schroeder, David Brown, Jennifer Tullet, Ian Brown and Martin Warren. doi.org/10.1016/j.chembiol.2018.04.012
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Notes to Editors
Sir Roger Manwood School – teachers: Dr Jackie Wilson and Vicki Beale and pupils Megan Battenfield, Megan Betts, Alex Gallagher, Inga Loo, Shiree Kinder, George Morris, Emma Rudge, James Russell, Rebekah Smith, Maddy Stock, Pema Tamang, Elizabeth Westbrook, Himmy Wu, and Katie Fidock.
Established in 1965, the University of Kent – the UK's European university – now has almost 20,000 students across campuses or study centres at Canterbury, Medway, Tonbridge, Brussels, Paris, Athens and Rome.
It has been ranked 22nd in the Guardian University Guide 2018 and in June 2017 was awarded a gold rating, the highest, in the UK Government's Teaching Excellence Framework (TEF).
In the Times Higher Education (THE) World University Rankings 2015-16, it is in the top 10% of the world's leading universities for international outlook and 66th in its table of the most international universities in the world. The THE also ranked the University as 20th in its 'Table of Tables' 2016.
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In the National Student Survey 2016, Kent achieved the fourth highest score for overall student satisfaction, out of all publicly funded, multi-faculty universities.
Along with the universities of East Anglia and Essex, Kent is a member of the Eastern Arc Research Consortium.
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Kent has received two Queen's Anniversary prizes for Higher and Further Education.
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