UNC researchers discover how body temperature wrecks potential dengue, Zika vaccine

(University of North Carolina Health Care) A major route toward creating effective vaccines against dengue virus and Zika involves the E protein that covers the surface of each viral particle. But creating such a vaccine has proven difficult for a number of reasons. Now UNC School of Medicine researchers have delineated the details of one major barrier to a promising vaccine. It's something we all have — a natural body temperature of about 98.6 degrees.