UC Santa Cruz teams up, pools data to fight stomach cancer

The new genetic variant exchange aims to advance science and patient survival by combining vast amounts of gene variant data with corresponding clinical data.

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Credit: Jessica Xie

SANTA CRUZ, CA – Nov. 24, 2020 – Coinciding with Stomach Cancer Awareness Month in November, the UC Santa Cruz Genomics Institute is teaming up with the patient advocacy nonprofit No Stomach For Cancer to release a web portal designed to help researchers identify individuals at risk of heritable stomach cancers.

Dr. Melissa Cline will lead the work at UC Santa Cruz to support a global initiative to increase access to genomic variant data. Dr. Cline previously developed brcaexchange.org, a web portal dedicated to sharing information on mutations in the BRCA1 and BRCA2 genes and their role in cancer.

Born from an international summit, launched in 2016, BRCA Exchange is now visited roughly 2,000 times each month. Its users include genetic counselors and researchers evaluating the clinical impact of BRCA mutations and individuals who carry BRCA mutations and want to understand what their mutations mean for themselves and their families.

The newly created CDH1 Exchange will follow the model of BRCA Exchange, providing a unified view of CDH1 variant data from public resources, and presenting those data with data analysis tools for researchers.

“My team is hard at work on the CDH1 Exchange, and we look forward to launching this spring,” Cline said. “We are excited that this collaboration with No Stomach For Cancer will allow us to apply a proven model to another dangerous cancer,” Cline said.

Stomach cancer is typically detected in later stages when it has already spread to nearby tissues, making it very deadly: The average five-year survival rate is 29.3%. Stomach cancer is the fifth most common cancer type, with more than one million new cases a year globally and 28,000 within the United States. (nostomachforcancer.org/about/statistics)

Hereditary Diffuse Gastric Cancer (HDGC) is a rare subtype of stomach cancer that arises through inherited mutations in some genes, most notably CDH1 (see rare diseases.info.nih.gov). It has an earlier age of onset and a worse prognosis than most stomach cancers.

Estimates vary significantly regarding the lifetime risk of stomach cancer for individuals who carry a cancer-causing CDH1 mutation. With the most significant variability dependent on study criteria and gender, estimates range from 42-70% for males and 33-56% for females. Studies also estimate that females with a pathogenic CDH1 mutation have an additional 39-55% lifetime risk of developing breast cancer. (Blair 2020)

What’s hopeful is that individuals who carry these mutations can manage risk with screening and risk-reducing surgeries. And it is important to note that not every CDH1 mutation increases an individual’s cancer risk.

“Identifying those mutations that increase the risk of cancer is an active area of research and one in which the UC Santa Cruz Genomics Institute is proud to participate,” Cline said.

No Stomach For Cancer Scientific Advisory Council member and Ambry Genetics R&D Director of Translational and Clinical Research Dr. Rachid Karam observed, “HDGC is a devastating disease. There are many different sources of good scientific information on CDH1 variants on the internet, but it’s challenging to see all the information in one place.” According to Karam, who is also part of the Clinical Genome (ClinGen) CDH1 Variant Curation Expert Panel, the leading international expert panel on CDH1 variants, “CDH1 Exchange will make this work so much easier.”

No Stomach For Cancer Executive Director Jon Florin recalled, “When I first saw BRCA Exchange, I was inspired to create a similar resource for CDH1 variants.” Florin continued, observing, “This will make a difference in the lives of people with a history of diffuse gastric cancer in their families. People will understand if they have inherited their family’s heritable cancer risk, and they can then have well-informed discussions with their doctors on how to manage the risk.”

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About the UC Santa Cruz Genomics Institute

Comprising diverse researchers from various disciplines across academic divisions, the UC Santa Cruz Genomics Institute leads UC Santa Cruz’s efforts to unlock the world’s genomic data and accelerate breakthroughs in health and evolutionary biology. Our platforms, technologies, and scientists unite global communities to create and deploy data-driven, life-saving treatments, and innovative environmental and conservation efforts. Learn more at genomics.ucsc.edu.

About the Baskin School of Engineering

Home to the UC Santa Cruz Genomics Institute, the Baskin School of Engineering at UC Santa Cruz offers unique education, research, and training opportunities. Faculty and students seek new approaches to critical 21st-century challenges within the domains of data science, genomics, bioinformatics, biotechnology, statistical modeling, high-performance computing, sustainability engineering, human-centered design, communications, cyber-physical systems, optoelectronics and photonics, and networking. By leveraging novel tools that emerge from changing technologies, we have pioneered new engineering approaches and disciplines, such as biomolecular engineering, computational media, technology, and information management. Learn more at soe.ucsc.edu.

About No Stomach For Cancer

No Stomach For Cancer is a 501(c) (3) nonprofit organization whose mission is to support research and unite the caring power of people worldwide affected by stomach cancer. NSFC advances awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provides a support network for affected families and supports research for screening, early detection, treatment, and stomach cancer prevention. Headquartered in Wisconsin and serving patients worldwide, No Stomach For Cancer is a worldwide thought leader in stomach cancer awareness and education. Stomach cancer is currently the second leading cause of cancer deaths worldwide, with over 1,000,000 new cases diagnosed each year. For more information, please visit http://www.nostomachforcancer.org.
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