TSRI team wins $1.8 million to study early events in cancer metastasis

LA JOLLA, CA – November 2, 2015 – Cancer metastasis occurs when tumor cells escape from a primary tumor, via the blood stream, and establish tumors in secondary locations. When the metastases are found in distant tissues and organs, doctors call this stage IV cancer, and the survival rate is low.

Now scientists at The Scripps Research Institute (TSRI) have been awarded a grant of more than $1.8 million from the National Institutes of Health's National Cancer Institute to investigate the molecular machinery involved in metastasis. This basic research could one day point to new approaches to help patients.

"We think we'll be able to relate specific molecules on the tumor cell surface and irreversible modifications of these molecules to patient outcomes," said TSRI Professor James Quigley, who will co-direct the five-year project with TSRI Assistant Professor Elena Deryugina.

The researchers will focus on transmembrane proteins, which carry signals from outside a tumor cell to the cell's interior. In a previous study, the researchers found that the body's enzymes outside tumor cells can cut–or "cleave"–a cancer-related transmembrane protein called CDCP1. Instead of deterring the cancer, the cleavage appeared to make CDCP1 signals even stronger, supporting survival of tumor cells in the blood stream and their metastasis throughout the body.

"We also found that if you block cleavage or make CDCP1 non-cleavable, you could dampen the level of metastasis," said Deryugina, underlining the potential clinical significance of the work.

With the new grant, the researchers will investigate the nature of the cleaving enzymes and whether cleavage changes signaling in other transmembrane proteins involved in tumor cell survival and metastasis.

The researchers will also analyze cancer patient data provided by the University of California, San Diego to explore links between cleaved proteins and patient survival.

The number of the grant is 2R01CA105412.


About The Scripps Research Institute

The Scripps Research Institute (TSRI) is one of the world's largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs about 2,700 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists–including two Nobel laureates–work toward their next discoveries. The institute's graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see http://www.scripps.edu.