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The sea cucumber genome points to genes for tissue regeneration

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Credit: Qiang Xu

A new high-definition genome sequence of the sea cucumber provides molecular insights into its ability to regenerate, according to a new study publishing 12 October in the open access journal PLOS Biology by Xiaojun Zhang, Lina Sun, Hongsheng Yang and Jianhai Xiang, of the Institute of Oceanology, Chinese Academy of Sciences, and colleagues. The genome sequence also helps explain why the sea cucumber has such a radically different skeletal structure from other members of the echinoderm phylum, and may be useful for understanding evolution of the animal kingdom.

Sea cucumbers form one class of the echinoderms, a phylum that also includes sea urchins and sea stars ("star fish"). Echinoderms and chordates (a closely related phylum that includes humans) share a feature that distinguishes them from most other animals: they are so-called deuterostomes, in which the anus, rather than the mouth, forms first in development. Sea cucumbers are unique among echinoderms in not having a hardened calcium exoskeleton, and in their capacity to regenerate damaged or lost body parts and viscera to a much greater extent than sea urchins or sea stars.

To explore the genetic underpinnings of these features, and to better understand the evolution of the deuterostomes, the authors performed high-definition genomic sequencing of the sea cucumber Apostichopus japonicus (also known as the Japanese sea cucumber), covering about 92% of its estimated 880 megabases of DNA, including more than 30,000 genes.

By comparing the genome of A. japonicus with that of other organisms, the authors found evidence that the echinoderms diverged from hemichordates (a small group of marine deuterostomes that includes the acorn worms) about 533 million years ago and the sea cucumbers split off from other the echinoderm classes about 479 million years ago. The authors showed that while the sea urchin genome includes 31 genes for biomineralization, critical for forming a calcified skeleton, the sea cucumber has only seven such genes. They also found that the sea cucumber expressed these biomineralization genes at much lower levels throughout development, likely accounting for their softer bodies compared to sea urchins.

As a strategy to scare off predators, sea cucumbers can expel their viscera, which they can then regenerate within several weeks. The authors found a group of duplicated genes, called PSP94-like genes, that were specifically expressed in the regenerating intestines of the sea cucumber, which had no corresponding genes in other echinoderms, suggesting that these genes may be crucial to the animals' ability to quickly regrow their viscera. A second group of genes, called fibrinogen-related proteins, were also duplicated and highly expressed during regeneration, indicating they likely contribute to this ability as well.

"The sea cucumber is a particularly promising model animal for regenerative medicine," said Xiang, and the availability of its genome should aid efforts to study the biology of regeneration and determine if echinoderm regrowth can offer insights that can be applied to human medicine. "Our findings should also facilitate the understanding of the requirements for sustainable utilization and effective breeding of echinoderms, in support of the high-value sea cucumber industry," which includes its use as a source of food and traditional Chinese medicine.

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In your coverage please use this URL to provide access to the freely available article in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003790

Citation: Zhang X, Sun L, Yuan J, Sun Y, Gao Y, Zhang L, et al. (2017) The sea cucumber genome provides insights into morphological evolution and visceral regeneration. PLoS Biol 15(10): e2003790. https://doi.org/10.1371/journal.pbio.2003790

Funding: The National High-Technology Research and Development Program of China http://program.most.gov.cn/ (grant number 2012AA10A404, 2012AA092205). Received by JX and XZ. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Strategic Priority Research Program of the Chinese Academy of Sciences http://www.cas.cn/xxgkml/zgkxyyb/kxyj/xdzx/ (grant number XDA11020703, XDA11020704). Received by LZ, CLin, and HY. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. National Natural Science Foundation of China http://www.nsfc.gov.cn/ (grant number U1406404, 31272397). Received by HY and SJ. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology http://www.qnlm.ac/index (grant number 2015ASKJ02-03). Received by JX. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

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Jianhai Xiang
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http://www.plos.org

Related Journal Article

http://dx.doi.org/10.1371/journal.pbio.2003790

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