The Lancet Psychiatry: Life-course-persistent antisocial behaviour may be associated with differences in brain structure

MRI brain scans suggest there are characteristic differences in brain structure of individuals who exhibit life-course-persistent antisocial behavior

MRI brain scans suggest there are characteristic differences in brain structure of individuals who exhibit life-course-persistent antisocial behaviour.

Individuals who exhibit life-course-persistent antisocial behaviour – for example, stealing, aggression and violence, bullying, lying, or repeated failure to take care of work or school responsibilities – may have thinner cortex and smaller surface area in regions of the brain previously implicated in studies of antisocial behaviour more broadly, compared to individuals without antisocial behaviour, according to an observational study of 672 participants published in The Lancet Psychiatry journal.

However, there were no widespread structural brain abnormalities observed in a larger group of individuals who exhibited antisocial behaviour only during adolescence.

Previous epidemiological studies have demonstrated marked individual differences in the age of onset and duration of antisocial behaviour. Some individuals display life-course-persistent antisocial behaviour that begins in childhood and lasts into adulthood, whereas for others antisocial behaviour arises in adolescence but desists as they mature into adulthood.

The study is the first to compare structural brain differences using neuroimaging in individuals with either life-course-persistent or adolescent-only antisocial behaviour and those without antisocial behaviour, providing the first robust evidence to suggest that underlying neuropsychological differences are primarily associated with life-course-persistent persistent antisocial behaviour.

Lead author Dr Christina Carlisi, UCL, UK, says: “Our findings support the idea that, for the small proportion of individuals with life-course-persistent antisocial behaviour, there may be differences in their brain structure that make it difficult for them to develop social skills that prevent them from engaging in antisocial behaviour. These people could benefit from more support throughout their lives.” [1]

Continuing, she cautions: “Most people who exhibit antisocial behaviour primarily do so only in adolescence, likely as a result of navigating socially difficult years, and these individuals do not display structural brain differences. It is also these individuals who are generally capable of reform and go on to become valuable members of society.” [1]

The study used MRI brain scans from 672 participants aged 45 years. Based on reports from parents, carers and teachers, as well as self-reports of conduct problems between ages seven and 26 years old, the 672 participants were previously categorised in terms of the patterns of behaviour they exhibited – 12% (80 people) had life-course-persistent antisocial behaviour, 23% (151) had adolescent-only antisocial behaviour, and 66% (441) had no history of persistent antisocial behaviour.

Analysing the brain scans, the authors measured and compared the average cortical thickness and cortical surface area (indices of grey matter – a type of brain tissue – size), between these three groups. They also analysed differences in the surface area and cortical thickness of 360 different regions of the cortex.

On average, across the entire brain, individuals with life-course-persistent antisocial behaviour had a smaller mean surface area and lower mean cortical thickness than people who showed no persistent antisocial behaviour. In addition, people who showed life-course-persistent antisocial behaviour had reduced surface area in 282 of 360 brain regions, and had thinner cortex in 11 of 360 regions, most of which have been previously linked to antisocial behaviour through their involvement in goal-directed behaviour, regulation of emotions, and motivation.

However, widespread differences in brain structure were not found for the adolescence-limited group compared with either non-antisocial or life-course-persistent antisocial groups.

The authors say their findings provide the first robust evidence to suggest that underlying neuropsychological differences exist in people with life-course-persistent antisocial behaviour and have implications for the way we treat juvenile offenders.

Adolescents exhibiting life-course-persistent antisocial behaviour which began in childhood are often diagnosed with conduct disorder, and these children are at an increased risk for incarceration and poor physical and mental health later in life. [2]

Co-author Terrie Moffitt, Duke University, USA, says: “Political approaches to juvenile offending often swing back and forth between punitive measures and approaches that give young offenders room to reform. Our findings support the need for different approaches for different offenders – however, we caution against brain imaging being used for screening, as the understanding of brain structure differences are not robust enough to be applied on an individual level. Instead, we need to recognise that individual development can be one driver of serious repeat offending, but to also appreciate that this is not the case for all juvenile offenders.” [1]

Acknowledging the limitations of their study, co-author Professor Essi Viding, UCL, UK, cautions: “It is unclear whether these brain differences are inherited and precede antisocial behaviour, or whether they are the result of a lifetime of confounding risk factors (eg, substance abuse, low IQ, and mental health problems) and are therefore a consequence of a persistently antisocial lifestyle.”

The authors call for more long-term studies of antisocial behaviour which include multiple measurements of behaviour, brain, genes, and environment to understand how life-course-persistent antisocial behaviour unfolds.

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NOTES TO EDITORS

This study was funded by US National Institute on Aging, Health Research Council of New Zealand, New Zealand Ministry of Business, Innovation and Employment, UK Medical Research Council, Avielle Foundation, and Wellcome Trust. It was conducted by researchers from University College London, London, UK, Duke University, USA, King’s College London, London, UK, University of Otago, Dunedin, New Zealand, Rangahau Roro Aotearo Centre of Research Excellence, Dunedin, New Zealand.

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[1] Quote direct from author and cannot be found in the text of the Article.

[2] https://moffittcaspi.trinity.duke.edu/sites/moffittcaspi.trinity.duke.edu/files/rivenbark_jcpp2018_0.pdf

Peer-reviewed / Observational study / People

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