Thursday, June 1, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Technology and Engineering

Taming random gene changes as our bodies start to form

May 15, 2018
in Technology and Engineering
0
Share on FacebookShare on Twitter
IMAGE

Credit: Cincinnati Children's

CINCINNATI – Scientists exploring how to tame random gene fluctuations as the embryos that become our bodies start to form have identified a control switch in the vertebrate segmentation clock of developing zebrafish. The researchers report in Cell Reports their findings could uncover methods for modulating genetic signals to prevent birth defects or cancers rooted at the earliest stages of development.

A multi-institutional team studies developmental systems in zebrafish because the vertebrates share common genes with humans and are ideal models for studying early human development, says the study's principal investigator, Ertugrul Ozbudak, PhD, a member of the Division of Developmental Biology at Cincinnati Children's Hospital Medical Center.

In this study, Ozbudak and colleague examined vertebrate development at a stage called somitogenesis–or when bilaterally paired blocks of cells called somites form along the front-to-rear-axis of the embryo. In vertebrates, somites become the deeper layers of skin, cartilage, skeletal muscle, etc.

The researchers counted single transcripts (or copies) of genes in the zebrafish segmentation clock. They showed that clock genes have very low amplitudes of RNA (ribonucleic acid). RNA carries genetic instructions that control proteins and tissue-forming cells. The authors demonstrate the random variables in genetic signals during somitogenesis aren't controlled from inside the genes. Instead, they are driven by external sources of noise, such as the effects of metabolism, etc.

These externally driven fluctuations in gene signaling are suppressed by the Notch pathway of genes and proteins. Notch is known to act as a control switch between cell expansion and the transformation of cells into specific tissue types. The researchers demonstrate it also serves this role during zebrafish somitogenesis.

"Our results suggest variability in gene expression is controlled by a balance between time delays and when cells are actively signaling in vertebrate tissue," says Ozbudak. "Further investigation should shed light on the accuracy of natural development clocks in animals and humans, and this could help inspire the development of robust synthetic oscillators that might help prevent certain birth defects or cancers."

Looking to the Future

Although the potential of this research having a beneficial clinical impact remains years away, the work gives scientists new possibilities for exploring how life forms–and how this new knowledge could positively impact health, according to the researchers.

Take the possibility of trying to a prevent cancer. During embryonic development, Notch is busy working as an activator of genes in the Hes family, according to Ozbudak. Hes genes are known to vary their signaling during early development of the vertebral column, as well as in other tissues.

Dysregulated Hes genes are also highly expressed in several types of human cancer, including rhabdomyosarcoma, a cancer affecting the body's connective tissues. The ability to oscillate and control gene expression at the earliest stages of development raises the question of whether it might be possible to stop early genetic programming as an embryo forms that might cause cancer years after a person's birth.

###

Collaborating Institutions, Funding Support

Also collaborating on the study were scientists from the Department of Genetics at Albert Einstein College of Medicine, the departments of Computer Science, Biology and Mathematics at Colgate University, and the departments of Electrical and Computing Engineering, Biomedical Engineering and Mathematical Sciences at the University of Delaware.

Funding support came in part from the National Institutes of Health (GM111987, GM122956) and a Colgate Picker Interdisciplinary Science Institute Grant.

Media Contact

Nick Miller
[email protected]
513-803-6035
@CincyChildrens

http://www.cincinnatichildrens.org

Related Journal Article

http://dx.doi.org/10.1016/j.celrep.2018.04.069

Share25Tweet16Share4ShareSendShare
  • blank

    Why expensive wine appears to taste better

    71 shares
    Share 28 Tweet 18
  • Artificial intelligence system predicts consequences of gene modifications

    67 shares
    Share 27 Tweet 17
  • “You must have a preference”: How does lack of preference affect joint decision-making?

    67 shares
    Share 27 Tweet 17
  • Finally solved! The great mystery of quantized vortex motion

    64 shares
    Share 26 Tweet 16
  • New 3D printing technique ready to advance manufacturing

    64 shares
    Share 26 Tweet 16
  • Element creation in the lab deepens understanding of surface explosions on neutron stars

    75 shares
    Share 30 Tweet 19
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

Element creation in the lab deepens understanding of surface explosions on neutron stars

Why expensive wine appears to taste better

Study finds that eight factors put Black adults at greater risk of early death

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 206 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In