The research team followed 156 adults who developed invasive pneumococcal disease and required hospital care in Region Västra Götaland, Sweden, between 2018 and 2023. The median age of the patients was 70 years, a demographic in which both pneumococcal disease and blood malignancies become progressively more common. To determine whether the severe infection was merely bad luck or a signal of hidden vulnerability, the researchers performed detailed immunological workups. They measured antibody levels to detect deficiencies in humoral immunity, and they tested for the presence of M protein, a monoclonal immunoglobulin that serves as a well-established risk marker for blood cancer. A control group of 64 individuals, matched for age and sex but without invasive pneumococcal disease, provided a baseline for comparison.

The results were striking. Among the patients with invasive pneumococcal disease, one in four had M protein detectable in their blood. Monoclonal gammopathy of this kind can occur in established blood cancers, but it is also found in precursor states, conditions that do not yet meet the criteria for malignancy but can, in some patients, progress toward cancer over time. The examinations prompted by the study led to seven patients receiving a diagnosis of blood cancer, while another twelve were diagnosed with a precursor condition that may, in some cases, evolve into malignancy. In a group of just over 150 patients admitted for a severe bacterial infection, that represents a meaningful yield of previously silent disease.

The immune assessments also uncovered antibody deficiencies. Eight patients in the pneumococcal disease group were found to have immunodeficiency, and in seven of them, clinicians were able to start preventive treatment aimed at protecting against future severe infections. Such treatments can include replacement immunoglobulin therapy and tailored vaccination strategies, interventions that can substantially reduce the risk of recurrent invasive disease. By contrast, these abnormalities were considerably less common in the matched control group, reinforcing the idea that invasive pneumococcal infection is not randomly distributed but clusters in people whose immune surveillance is compromised.

The biological logic behind these findings is straightforward once the mechanics of pneumococcal immunity are considered. Streptococcus pneumoniae is an encapsulated bacterium, and its polysaccharide capsule is the principal target of protective antibodies. Clearance of the organism depends heavily on opsonization, the process by which antibodies coat the bacterium and mark it for destruction by phagocytic cells. People with low antibody levels, whether from a primary immunodeficiency or from the antibody-producing B-cell disorders that underlie many blood cancers, are therefore structurally less able to contain the bacterium when it colonizes the respiratory tract. What would be a mild or localized infection in an immunocompetent adult can become a systemic, hospital-requiring illness in someone whose humoral immunity is impaired.

M protein, the marker at the center of the study, is a monoclonal immunoglobulin produced by a single expanded clone of plasma cells or B cells. Its presence in the blood is the hallmark of a spectrum of disorders ranging from the benign-appearing monoclonal gammopathy of undetermined significance to smoldering and symptomatic myeloma. Because monoclonal gammopathies are common in older populations and often remain asymptomatic for years, most are discovered incidentally or not at all. The Gothenburg study suggests that severe pneumococcal disease may function as a clinical flag: when an older adult presents with invasive infection, the probability of finding an underlying monoclonal disorder is high enough that targeted testing could be worthwhile.

Currently, according to the researchers, these tests are not routinely performed after a severe pneumococcal infection. Tor Härnqvist, a doctoral student at the University of Gothenburg and an infectious disease physician at NU Hospital Group, and one of the lead authors of the study, points to the consequence of that gap. “Currently, these tests are not routinely performed after a severe pneumococcal infection. As a result, we may miss patients with undiagnosed blood cancer or immunodeficiency and therefore missing the opportunity to initiate treatment,” he says. The missed opportunity cuts in two directions: blood cancers such as myeloma are generally more treatable when identified before organ damage accumulates, and immunodeficiencies can be mitigated with preventive measures before the next invasive infection occurs.

The study carries implications for vaccination policy as well. Karin Bergman, a doctoral student in the same research group and an infectious disease physician at Södra Älvsborg Hospital, examined how the pneumococcal bacteria causing severe disease have shifted since the pneumococcal conjugate vaccine was introduced into the Swedish childhood vaccination program. Her analysis, part of a doctoral thesis she will soon defend at the University of Gothenburg, shows that the bacterial serotypes covered by the childhood vaccine have decreased sharply in circulation, but they have largely been replaced by other serotypes against which the childhood vaccine offers no protection. This serotype replacement is a well-documented ecological consequence of conjugate vaccination: eliminating vaccine-targeted strains from nasopharyngeal carriage opens ecological space for non-vaccine strains to colonize and spread.

Crucially, the serotypes now driving invasive disease in adults disproportionately affect older adults and individuals with underlying conditions, particularly cancer and compromised immune systems. This creates an uncomfortable alignment: the very populations most vulnerable to severe pneumococcal infection are those most likely to harbor undiagnosed blood cancer or antibody deficiency, and the circulating bacterial strains are precisely those that exploit gaps in adult immunity. “The results show that recommendations on pneumococcal vaccines for adults need to take into account which vaccines are used in children and which bacterial serotypes subsequently circulate in the community,” says Bergman. In other words, adult immunization strategy cannot be designed in isolation from the pediatric program, because the two are epidemiologically linked through the shifting serotype landscape.

Taken together, the findings support a concrete change in clinical practice. The researchers argue that screening for M proteins and antibody levels should be considered in adults who experience invasive pneumococcal disease, since the infection can reveal previously undiagnosed blood cancer and immunodeficiency. Such screening would involve relatively simple blood tests: quantitative measurement of serum immunoglobulins to identify antibody deficiencies, and protein electrophoresis or equivalent methods to detect monoclonal immunoglobulins. For a patient population that is already hospitalized and undergoing extensive workup, the incremental burden would be modest, while the potential benefit, catching a blood cancer or an immune deficiency that would otherwise remain hidden until it caused further harm, could be substantial. As populations age and serotype replacement continues to reshape pneumococcal epidemiology, the severe pneumonia that lands an older adult in the hospital may increasingly deserve to be read not only as an infection, but as a message from the immune system itself.

Subject of Research: Invasive pneumococcal disease as a marker of undiagnosed blood cancer and immunodeficiency in adults

Article Title: Pneumonia can reveal undiagnosed blood cancer

Article References: Pneumonia can reveal undiagnosed blood cancer. (n.d.). Original publication

Image Credits: AI Generated

DOI: Not provided

Keywords: pneumococcal disease, pneumonia, blood cancer, M protein, immunodeficiency, monoclonal gammopathy, Streptococcus pneumoniae, antibody deficiency, pneumococcal vaccine, serotype replacement, University of Gothenburg, Scientific Reports

The study, published in the journal Appetite, combined a large-scale survey with in-depth qualitative discussions, a mixed-methods design that allowed the researchers to measure attitudes across a broad population while also probing the reasoning behind them. In the autumn of 2021, the team surveyed students in grades 4 through 9 at six schools in Lund Municipality, with the main statistical analyses including 1,268 students. To complement the survey data, the researchers held qualitative sessions with 20 students at two of the schools, giving participants space to articulate in their own words what they thought about meals designed with the climate in mind.

The results defied any simple narrative of either enthusiastic support or stubborn resistance. Students were neither clearly positive nor clearly negative about more climate-friendly school meals. Instead, attitudes were strikingly mixed: around four in ten students in the survey described themselves as neutral toward the idea, while roughly equal proportions were positive and negative. That distribution matters for policymakers, because it suggests that the success or failure of climate-oriented menu changes is not predetermined by a hostile student body but is instead contingent on how the changes are designed and communicated.

What did predict a positive attitude? The strongest associations appeared with factors rooted in students’ own food choices and habits. Students who said they considered climate important when choosing food expressed markedly more positive attitudes toward climate-friendly school meals, as did those who ate vegetarian food at school more often. Gender also played a role, with girls expressing more positive attitudes than boys across the sample. These patterns indicate that personal engagement with sustainability and repeated, everyday exposure to vegetarian dishes go hand in hand with acceptance, hinting that familiarity built through routine may be one of the most powerful tools available to school kitchens.

Perhaps the most sobering finding concerned knowledge. Awareness that red meat has a larger climate footprint than vegetarian food was high even among students who held more negative attitudes toward climate-friendly meals, and this awareness was only weakly associated with their attitudes. In other words, information alone does not change how young people feel about what lands on their plate. As Monica Hunsberger, associate professor of public health at Sahlgrenska Academy at the University of Gothenburg, put it: “Students are aware of the climate footprints of foods, but when it comes time for lunch, other things become more important. Above all, they think about whether the food tastes good, fills them up, and feels familiar.”

The qualitative sessions illuminated why those three qualities carry so much weight. In the discussions, meat emerged as the norm against which many students judged what counted as a proper, filling meal. Vegetarian dishes were not evaluated in a vacuum; they were measured against this meat-centered expectation and were received better when they resembled foods the students already knew and liked. This finding has practical implications for menu design: vegetarian options that mimic familiar formats and flavors are likely to face less resistance than dishes that depart radically from what students recognize as a complete lunch.

The study also compared two distinct strategies for reducing the carbon footprint of school meals, and the difference between them was telling. Students were somewhat more supportive of reducing the amount of meat within existing recipes than of adding more all-vegetarian days to the weekly schedule. In the discussions, students described recipe modification as easier to accept, a preference that aligns with the broader pattern of familiarity driving acceptance. At the time of the study, the participating schools already served one or two all-vegetarian days per week, so students were responding from lived experience rather than abstract speculation about what such days might mean.

The research was conducted in connection with a practical intervention reported in an earlier study, in which the carbon footprint of school meals was reduced by 20 percent without affecting how much students ate or how satisfied they were with the food. That earlier result demonstrated that meaningful emissions reductions are technically achievable in real school kitchens without compromising quantity or satisfaction. The new study adds the crucial social dimension, showing that the pathway to student acceptance runs through sensory and experiential qualities rather than through climate messaging alone.

Erik André, a doctoral student at Chalmers University of Technology and the City of Gothenburg, framed the findings as guidance for kitchen staff and administrators. “Many school kitchens already work on modifying recipes so that they contain smaller amounts of ingredients with a high climate footprint, while also serving a high proportion of vegetarian dishes. This study suggests that such recipe reformulation can be a useful complementary approach for reducing climate impact while ensuring that the food is still appreciated by students,” he said. The message is one of pragmatism: rather than framing the transition as a choice between meat-heavy tradition and an all-vegetarian future, schools can pursue incremental reformulation that preserves the sensory qualities students value.

Taken together, the findings arrive at a moment when school food systems across Europe and beyond are under pressure to align public procurement with climate goals. School meals reach millions of children daily, making them one of the most scalable levers for reducing food-related emissions, and Sweden has been among the countries most actively experimenting with lower-footprint menus. What this study contributes is a reminder that behavioral science and sensory science belong at the center of that transition. Students are not blank slates waiting to be informed; they are discerning eaters with established norms about what a meal should be. Meeting them where they are, with food that tastes good, satisfies hunger, and echoes familiar dishes, may accomplish what facts alone cannot: turning climate-friendly school meals from a policy mandate into a lunch that students genuinely want to eat.

Subject of Research: Students' perceptions of climate-friendly school meals in Swedish primary and secondary schools

Article Title: Taste crucial to students’ support for climate-friendly school meals

Article References: Taste crucial to students’ support for climate-friendly school meals. (n.d.). Original publication

Image Credits: AI Generated

DOI: Not provided

Keywords: school meals, climate-friendly food, food sustainability, vegetarian diets, student attitudes, red meat footprint, recipe reformulation, University of Gothenburg, Chalmers University of Technology, Appetite journal, mixed-methods study, food acceptance

The research forms part of The Rise II project, a large-scale initiative based at the University of Gothenburg that seeks to reinterpret key processes of European prehistory by integrating ancient DNA, isotopic investigations, linguistics and archaeology. Within that framework, the new paper, titled Exploring mobility in Bronze Age Greece: A Sr isotope perspective, set out to answer two deceptively simple questions: how did human mobility change throughout the Bronze Age, and whether the movement of people was driven by specific identifiable factors. The answers, according to the team, complicate a picture that earlier scholarship had painted in broad and often gendered strokes.

The analytical foundation of the study rests on a well-established principle of geochemistry. Strontium enters the human body through water and food, both of which are typically gathered from the immediate environment in premodern societies. Because the strontium isotope signature of a landscape reflects the age and composition of its underlying geology, that signature is transferred into human bones and teeth during growth and mineralization. Dental enamel, which forms in childhood and does not subsequently remodel, preserves the isotope composition of the place where a person spent their early years. By comparing the values measured in skeletal samples against so-called bioavailable baselines established for the region surrounding each burial site, researchers can determine with a significant degree of certainty whether an individual was local or grew up elsewhere.

Applying this method to 199 individuals from six sites, the team found that non-local people were present in every community examined. The consistency of the figure, holding at roughly five to ten percent across the sampled populations, suggests that foreign-born residents were a normal and enduring feature of Bronze Age Greek society rather than an occasional anomaly tied to a single period or place. The Mediterranean world of the third and second millennia BCE witnessed profound socio-cultural and economic transformations, varying across regions and over time, and expanding exchange networks are known to have played an important role in these developments. What remained poorly understood until now was the extent to which the movement of goods was accompanied by the migration and settlement of foreign individuals within local communities.

One of the study’s most striking findings concerns gender. Previous research has often suggested that women were more likely to move between communities, particularly through marriage in patrilineal societies, a pattern documented in various prehistoric contexts and widely invoked to explain the spread of technologies and styles. The new data do not support such a one-sided picture for Bronze Age Greece. The number of non-local women and men proved to be comparable, indicating that several different factors, rather than marriage alone, may have driven an individual’s mobility. As Serena Sabatini, associate professor of archaeology at the University of Gothenburg, noted, this balance suggests a more complex set of motivations behind movement, potentially including trade, craft specialization, diplomatic exchange and other forms of contact that the expanding Bronze Age networks encouraged.

Status, too, appears to have had little bearing on who moved. Non-local individuals were identified across different burial practices, appearing both in unremarkable graves and in richly furbished ones. This distribution reveals that people were mobile regardless of their wealth or social standing, and that foreigners were integrated into their adopted communities to the point of receiving burial treatment consistent with local norms. For archaeologists, the finding is significant because burial opulence is often used as a proxy for social hierarchy; the new evidence shows that a wealthy grave could belong to someone born far away just as easily as to a member of the local elite, and that mobility was not the privilege of a mobile merchant class alone.

The age profile of the migrants adds another layer of nuance. No foreigners were identified among the investigated children, which is to say that the youngest individuals in the sample all carried isotope signatures matching their burial regions. Young adults under the age of thirty, by contrast, were the group most likely to be non-local. Taken together, these patterns suggest that mobility and migration in Bronze Age Greece concerned, to a considerable extent, single young individuals rather than the relocation of entire families. Whether these young movers arrived as traders, craftspeople, marriage partners, or in other capacities, the data indicate that they arrived as individuals and were buried within the communities that received them.

The methodological strength of the study lies in its scale and its grounding in regional baselines. Strontium isotope analysis has become one of the most powerful tools in modern archaeology precisely because it sidesteps the assumptions embedded in grave goods or architectural styles, which can travel through trade without any human movement at all. By measuring the isotope ratios directly in human tissue, researchers gain a biological record of where a person drew their food and water during the years their skeleton was forming. The 199 skeletal samples analyzed here, drawn from excavations across central and southern Greece, allowed the team to track how mobility behaved across both space and time within the Bronze Age, rather than relying on isolated case studies that might reflect local idiosyncrasies.

The broader implications reach well beyond the Aegean. The Bronze Age Mediterranean is often narrated as a world connected by the exchange of metals, textiles and prestige goods, with palatial centers in the Aegean, the eastern Mediterranean and beyond linked by maritime routes. The new findings demonstrate that this connectivity had a human dimension that was demographically meaningful yet socially diffuse: a small but persistent fraction of every community was foreign-born, drawn from both sexes and all levels of wealth. Such a pattern implies that prehistoric exchange networks did not merely move objects between distant elites but also moved people into the everyday fabric of local life, where they lived, worked and were eventually buried alongside their neighbors.

The study also serves as a corrective to lingering stereotypes about prehistoric societies. The assumption that women moved and men stayed, rooted in models of patrilineal marriage exchange, has shaped interpretations of genetic and archaeological data across Europe. By showing comparable numbers of non-local men and women in Bronze Age Greece, the Gothenburg-led team argues that mobility was a multifaceted phenomenon, produced by a range of social and economic forces that varied from person to person. The research, published open access in PLOS One on 23 September 2026, offers a template for future work across the Mediterranean and Europe, where the combination of large skeletal samples, regional isotope baselines and archaeological context promises to reveal, community by community, how the ancient world was knit together not only by goods and ideas but by the quiet, persistent movement of people themselves.

Subject of Research: Bronze Age human mobility in Greece determined through strontium isotope analysis of skeletal remains

Article Title: New study reveals Bronze Age mobility across ancient Greece

Article References: New study reveals Bronze Age mobility across ancient Greece. (n.d.). Original publication

Image Credits: AI Generated

DOI: Not provided

Keywords: Bronze Age, Greece, strontium isotopes, archaeology, human mobility, migration, PLOS One, University of Gothenburg, Mediterranean, isotope analysis, burial practices, ancient DNA