The research team, led by Larissa Pereira Santos and colleagues working with the GPQual palliative care and quality of life research group at Barretos Cancer Hospital and the National Cancer Institute in Rio de Janeiro, set out to fill a conspicuous gap in the literature. Handgrip strength has been extensively studied in community-dwelling older adults and in patients undergoing active cancer treatment, but data specific to specialized palliative care settings remain scarce. Even fewer studies have examined which factors are associated with low grip strength in this context, and, according to the authors, none had previously analyzed these factors separately for men and women. That distinction matters because of well-established muscular dimorphism, hormonal differences, and divergent trajectories of lean mass loss between the sexes.

The study was conducted between August 2023 and August 2025 at the palliative care unit of a national cancer referral center in Brazil. Patients attending their first outpatient visit were consecutively recruited if they were at least 20 years old, had metastatic disease confirmed by histological, cytological, or radiological evidence, or had local or locoregional recurrence without ongoing antineoplastic therapy. All participants had a Karnofsky Performance Status, or KPS, of at least 40 percent, a threshold chosen because the outpatient setting required participants to be physically capable of completing a standardized grip test. Patients with more severe functional impairment, who typically require inpatient care and substantial assistance with daily activities, were therefore not part of the final analytical sample.

The measurement protocol was rigorous. Grip strength was assessed bilaterally with a Jamar hydraulic dynamometer, the instrument widely regarded as a clinical standard. Patients sat with feet flat on the floor, knees flexed at 90 degrees, and arms resting at their sides, with the elbow of the tested limb bent at 90 degrees and the forearm in a neutral position. Each hand was tested three times in alternating fashion, with one-minute intervals between trials, and the highest value regardless of hand dominance was used for analysis. All measurements were performed by a trained nutritionist during the enrollment visit. Because no validated grip strength cutoffs exist specifically for patients with advanced cancer in palliative care, the researchers classified the lowest sex-specific tertile of their sample as low grip strength, which worked out to 12 kilograms or less for women and 20 kilograms or less for men.

The results were striking in their consistency. Among women, low grip strength was significantly more prevalent in those aged 60 or older, those without a marital relationship, those with fewer than nine years of formal education, those who had previously received chemotherapy or radiotherapy, those with comorbidities such as hypertension and cardiovascular disease, those with a KPS of 50 percent or below, and those flagged as being at nutritional risk by the Patient-Generated Subjective Global Assessment short form. Among men, low grip strength clustered in older patients, those with a partner, those with prior chemotherapy exposure, and those with reduced performance status. In the crude analyses, age, education, KPS, hypertension, cardiovascular disease, and nutritional risk all reached statistical significance for women, while age and KPS dominated for men.

But when the researchers built adjusted multivariable logistic regression models using a backward stepwise approach, the field narrowed dramatically. For women, only two variables survived: age of 60 or older, which carried an odds ratio of 2.29, and a KPS of 40 to 50 percent, which carried an odds ratio of 5.06. For men, the pattern was similar but even more pronounced for age, with an odds ratio of 4.02 for being 60 or older and 3.89 for the lowest KPS category. In practical terms, a woman with severely limited functional status was roughly five times more likely to fall into the weakest grip tertile than a comparable patient with better preserved function, and older men were about four times more likely than younger men to do so. The models accounted for 13 percent of the variability in women and 16 percent in men, a modest but meaningful share given the multifactorial nature of muscle weakness in advanced disease.

The convergence between low grip strength and poor performance status is biologically and clinically plausible, the authors argue, although the cross-sectional design prevents any claim of causation. Patients with KPS scores between 40 and 50 percent experience substantial limitations in daily activities and increased dependency, and the tight coupling of these variables suggests that a dynamometer reading may serve as a rapid, objective approximation of global functional capacity. The relationship is likely bidirectional: functional decline reduces muscle use and strength, while diminished strength in turn accelerates the loss of autonomy. This feedback loop is precisely what makes early detection valuable in palliative oncology, where interventions aimed at preserving function must be timed carefully.

The new findings align with a growing international evidence base. Studies in the oldest old have shown that weak grip predicts decline in daily activities, while work in advanced cancer patients has demonstrated that those with grip strength at or below the tenth percentile exhibit poorer performance status, reduced lean mass, greater fatigue, worse quality of life, higher prevalence of sarcopenia, lower body mass index, and reduced hemoglobin and albumin levels. A prospective study published in the Journal of Cachexia, Sarcopenia and Muscle found that lower grip strength was independently associated with increased mortality in patients with predominantly advanced cancer. Perhaps most tellingly, research in advanced or recurrent lung cancer found that muscle strength measures were associated with survival, whereas skeletal muscle mass alone was not. Grip strength, in other words, appears to capture something that imaging-based muscle mass assessments miss, and reductions in strength may even precede measurable losses of muscle mass, enabling earlier detection of functional impairment.

The clinical implications are immediate and pragmatic. A dynamometer costs little, requires seconds to use, and can be deployed in settings where complex performance-based tests are infeasible, including with frail individuals who cannot complete gait speed or chair-stand assessments. Identifying patients with weak grip can inform care planning, risk stratification, and resource allocation, and can trigger timely nutritional support, symptom management, or palliative rehabilitation. Notably, the study found that while 36 percent of women and 31 percent of men overall were classified as having low grip strength, the prevalence jumped to 63 percent in women and 71 percent in men who were both over 60 and had KPS scores of 50 percent or below. Age and performance status alone therefore cannot identify every vulnerable patient, but they can serve as accessible screening flags that direct clinicians toward formal dynamometry.

The authors are candid about the study’s limitations. The sample was predominantly older and functionally preserved, so the results may not extend to hospitalized patients or those with KPS below 40 percent. The use of sample-specific tertiles rather than externally validated thresholds limits comparability with studies applying the European or Asian Working Group for Sarcopenia criteria, and the similarity of the cutoffs to those from a prior palliative care study should not be read as external validation. The hydraulic dynamometer also requires a minimum force of three to four kilograms to register a reading, meaning the frailest patients who could not activate the device were excluded, which may have underestimated the true magnitude of muscle weakness. The assessor was not blinded to clinical information, introducing a potential for observer bias. Still, the researchers call for longitudinal studies to determine whether grip strength declines before functional deterioration, and for pragmatic trials testing whether intensive nutrition, physical therapy, or multimodal rehabilitation can alter the functional trajectory of these patients. If those questions are answered affirmatively, the humble grip test could become a routine vital sign of vulnerability at the end of life.

Subject of Research: Factors associated with low handgrip strength in patients with advanced cancer receiving palliative care

Article Title: Low handgrip strength in advanced cancer: associated factors and clinical implications in palliative care

Article References: Santos, L. P., Paiva, B. S. R., Da Costa Rosa, K. S., Paiva, C. E., & De Oliveira, L. C. (2026). Low handgrip strength in advanced cancer: associated factors and clinical implications in palliative care. Supportive Care in Cancer, 34(10), Article 1020. https://doi.org/10.1007/s00520-026-11249-x

Image Credits: AI Generated

DOI: 10.1007/s00520-026-11249-x

Keywords: handgrip strength, advanced cancer, palliative care, Karnofsky Performance Status, sarcopenia, cachexia, nutritional risk, functional decline, dynamometry, oncology, frailty, sex-stratified analysis