quantitative sensory testing in amyloidosis – Science https://scienmag.com Wed, 26 Aug 2026 06:05:10 +0000 en-US hourly 1 https://wordpress.org/?v=7.1 https://scienmag.com/wp-content/uploads/2024/07/cropped-scienmag_ico-32x32.jpg quantitative sensory testing in amyloidosis – Science https://scienmag.com 32 32 73899611 Long-term multimodal study reveals peripheral nerve involvement in wild-type transthyretin amyloidosis https://scienmag.com/long-term-multimodal-study-reveals-peripheral-nerve-involvement-in-wild-type-transthyretin-amyloidosis/ Wed, 26 Aug 2026 06:05:10 +0000 https://scienmag.com/long-term-multimodal-study-reveals-peripheral-nerve-involvement-in-wild-type-transthyretin-amyloidosis/ This article reports a prospective 1-year study of peripheral nerve involvement in wild-type transthyretin amyloidosis (ATTRwt) cardiomyopathy.

Key findings from the provided abstract:

  • 23 patients with ATTRwt were compared with healthy controls.
  • Small-fiber loss was common: abnormal intra-epidermal nerve fiber density occurred in 47.8% of patients vs. 4.3% of controls (p = 0.002).
  • Quantitative sensory testing was abnormal for nearly all measures except cold detection.
  • Sensory-predominant axonal polyneuropathy was identified in 82.6% of patients.
  • Greater neurological impairment was associated with higher symptom burden and fatigue.
  • The study used a multimodal evaluation including:
    • Neuropathy Impairment Score–Lower Limb
    • Nerve conduction studies
    • Quantitative sensory testing
    • Serum neurofilament light chain
    • Skin-biopsy assessment of intra-epidermal nerve fiber density
    • Norfolk QoL-DN and Chalder Fatigue scales

Overall implication: Peripheral nerve involvement—particularly sensory and small-fiber neuropathy—may be substantially more frequent in ATTRwt than traditionally recognized, even when cardiomyopathy is the dominant clinical presentation.

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