Cracking the code: researchers unravel how mutant protein drives cancer growth
Researchers from WEHI (Melbourne, Australia) have solved a mystery about the most important driver of cancer development - a mutant protein found in ...
Tag: mutant
Computer simulation suggests mutant strains of COVID-19 emerged in response to human behavior
Using artificial intelligence technology and mathematical modeling, a research group led by Nagoya University has revealed that human behavior, such ...
The uncharted role of HER2 mutant alleles in breast cancer
“Our research study has demonstrated that poziotinib is highly potent in neratinib-resistant HER2 L755S lobular and ductal breast cancer models ...
A secret passage for mutant protein to invade the brain
Researchers from Tokyo Medical and Dental University (TMDU) show that the protein involved in Parkinson’s disease, α-synuclein, can propagate through ...
Mutant KRAS regulates Y chromosome gene in colorectal cancer, driving metastasis and inhibiting anti-tumor immunity
HOUSTON ― Researchers at The University of Texas MD Anderson Cancer Center have uncovered a gene on the Y chromosome ...
The mutant origin of brain aneurysms and the first drug treatment
Researchers at the RIKEN Center for Brain Science (CBS) in Japan have discovered a set of related mutations that lead ...
Mutant strains of Salmonella make infection more aggressive in commercial poultry, study shows
In Brazil, a group of researchers supported by FAPESP created mutant forms of Salmonella to understand the mechanisms that favor colonization of ...
Oncotarget | Everolimus inhibits angiogenesis and lymphangiogenesis in TP53 mutant HNSCC by downregulating STAT3/HIF-1α/VEGF pathway
“ we sought to investigate the mechanism for everolimus-induced inhibition of TP53 HNSCC.” Credit: 2023 Alam et al. “ we ...
Development of a potential microRNA medicine against KRAS mutant cancers
The main points of this study are as follows. ・ KRAS mutations occur in approximately 40% of all human colorectal ...
Mount Sinai awarded three-year grant to explore therapeutic approaches to KRAS mutant lung tumors
(New York, NY – August 9, 2022) Mount Sinai is leading a team of lung cancer researchers that has been awarded ...
Novel T cell bispecific antibody shows potent anti-tumor activity in preclinical models of epidermal growth factor receptor variant III (EGFRvIII) mutant glioblastoma
Credit: Source: Vall d'Hebron Institute of Oncology (VHIO). Published in Molecular Cancer Therapeutics*, a journal of the American Association ...
Poziotinib is active in EGFR exon 20 mutant non-small cell lung cancer with efficacy highly dependent on insertion location
HOUSTON ― A Phase II clinical trial of poziotinib for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor ...
A potentially more effective treatment for HER2 mutant metastatic breast cancer
Breast cancers with HER2 mutations respond to the drug neratinib, but the responses are variable and often not durable. Looking ...
When and how mutant clones expand in normal endometrium
Niigata, Japan—Monthly menstruation is a biological phenomenon in women of reproductive age that involves morphological and functional changes in the ...
Mutant mice shed no tears
Kyoto, Japan -- Health issues for people over sixty commonly involve the heart and other vital organs. So do eye-related ...
BU researchers find “genetic baggage” accumulates in the genomes of aging mutant animals
EMBARGOED by PLOS GENETICS until March 3, 2022, 2 pm, ET Contact: Gina DiGravio, 617-358-7838, ginad@bu.edu (Boston)—You are probably ...
New method of targeting mutant RAS provides hope for cancer patients
As a 10-year journey comes to fruition, MUSC Hollings Cancer Center researcher John O’Bryan, Ph.D., and colleagues have demonstrated a new therapeutic way ...
Mutant stem cells defy rules of development
SAN FRANCISCO, CA—January 26, 2022—Imagine you’re baking a cake, but you run out of salt. Even with the missing ingredient, ...
It takes more than one mutant copy of the PIK3CA gene to make breast cancer more aggressive
Breast cancers that have an overactive PI3K enzyme, involved in cell growth and division, tend to be more aggressive and ...
Immunotherapy for intractable mutant cancer using a statin, hyperlipidemia drug
Third-generation cancer immunotherapy, a method of removing cancer using the body's immune system, has shown remarkable clinical benefits in recent ...
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Meteorites likely source of nitrogen for early Earth
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New implants linked to less infection and better recovery from orthopedic surgery
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New theory unites Einstein’s gravity with quantum mechanics
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‘Shocking’ discovery: Electricity from electric eels may transfer genetic material to nearby animals
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Why have so many new diseases developed in the bagged salads sector?
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New study identifies the greatest threat to wildlife across North America and Canada: people