Dr. Semla’s expertise lies in the intricate balance between utilizing pharmacological interventions and safeguarding against potential risks in elderly populations. His work has significantly contributed to the advancement of patient-centered medication management strategies, focusing on minimizing adverse drug reactions while ensuring therapeutic efficacy. Through his comprehensive approach, Dr. Semla has educated interdisciplinary teams encompassing pharmacists, physicians, nurses, and social workers, thereby enriching geriatrics care frameworks.

Paul Mulhausen, MD, MHS, FACP, AGSF and current AGS President, underscores Dr. Semla’s transformative impact on geriatrics. Dr. Semla’s early advocacy for interprofessional collaboration led to the inclusion of diverse healthcare disciplines as voting members within AGS in 1997, an innovation that substantially broadened the Society’s reach and effectiveness. His leadership roles culminated in becoming the Society’s first pharmacist president in 2007, highlighting his profound dedication to advancing the field.

Central to Dr. Semla’s contributions is his stewardship of the AGS Beers Criteria®, an evidence-based guideline identifying potentially inappropriate medication (PIM) use in older adults. Since 2012, he has co-chaired expert panels responsible for periodic updates of these criteria in 2012, 2015, 2019, and most recently in 2025. His leadership in this domain has been instrumental in shaping clinical policies aimed at reducing drug-induced complications in geriatric care.

A notable facet of Dr. Semla’s recent work includes the development of the 2025 “Alternative Treatments to Selected Medications in the American Geriatrics Society Beers Criteria®,” a clinical resource designed to offer safer and equally or more effective substitutes for PIMs. This tool is particularly critical in guiding therapeutic decision-making by integrating pharmacological innovations with geriatric-specific safety considerations, marking a new era of precision in prescribing practices.

For nearly three decades, Dr. Semla has also served as a co-author of “Geriatrics At Your Fingertips” (GAYF), a clinical compendium that condenses the latest geriatrics research into an accessible format for healthcare providers. This resource is heralded for its practical utility in real-world clinical settings, supporting improved outcomes by facilitating evidence-based medication choices tailored to the complex needs of older adults.

At the forthcoming Henderson Lecture, Dr. Semla intends to explore the historical trajectory and future directions of pharmacotherapy in aging populations, anchored by insights from the seminal 1968 Task Force on Prescription Drug Use. This landmark report, the U.S. government’s first dedicated to elderly medication use, laid the foundational principles for modern geriatric pharmacotherapy, emphasizing the urgent need for age-appropriate prescribing protocols.

Dr. Semla will critically examine key milestones in the evolution of geriatric medication management, including the identification of PIMs, the establishment of clinical tools to enhance medication safety, and the expanded roles pharmacists play in multidisciplinary care teams. He will analyze how evidence-driven interventions have transformed medication use, thereby reducing hospitalizations, adverse events, and improving quality of life for older adults.

Emphasizing the integral role pharmacists play in geriatric care, Dr. Semla reflects on how pharmacy professionals have transitioned from dispensers of medication to pivotal clinical partners who assess drug efficacy, monitor interactions, and advocate for patient-centered care plans. His lecture will highlight innovative models that harness pharmacists’ expertise to optimize therapeutic outcomes in complex geriatric populations.

Currently, Dr. Semla holds a clinical associate professorship at Northwestern University Feinberg School of Medicine and has an extensive background that includes clinical and hospital pharmacy, a geriatrics fellowship, and significant leadership within the U.S. Department of Veterans Affairs. His leadership in mental health and geriatrics pharmacy management has fortified medication stewardship programs benefitting thousands of older veterans.

As the AGS Annual Scientific Meeting gathers over 2,600 healthcare professionals from various disciplines in a virtual format on April 30–May 2, 2026, Dr. Semla’s lecture stands out as a culminating event underscoring the vital intersection of pharmacology and geriatric medicine. Attendees will gain insight into not only historical perspectives but promising innovations that will shape the future landscape of aging and medication use.

The AGS continues to champion interprofessional collaboration, recognizing that the complexities of aging require comprehensive care models that incorporate diverse expertise. Dr. Semla’s work exemplifies this approach, offering hope that with continued research, education, and clinical innovation, medication safety and efficacy for older adults can be continually enhanced.

For additional information regarding the Henderson State-of-the-Art Lecture or participation in the AGS 2026 Annual Scientific Meeting, interested professionals are encouraged to visit the AGS website at www.americangeriatrics.org. The Society remains committed to advancing geriatrics knowledge and improving the health, independence, and quality of life for older adults worldwide.

Subject of Research: Medication use and pharmacotherapy in older adults
Article Title: Todd P. Semla to Deliver 2026 Henderson State-of-the-Art Lecture on Advancements in Geriatric Pharmacotherapy
News Publication Date: April 17, 2026
Web References:

• American Geriatrics Society: www.americangeriatrics.org
• AGS 2026 Annual Scientific Meeting: https://meeting.americangeriatrics.org/
  Keywords: Geriatrics, Pharmacotherapy, Older adults, Medication safety, Beers Criteria®, Interprofessional care, Pharmacy, Evidence-based medicine, Drug therapy, Medication management, AGS, Clinical guidelines

Atypical antipsychotics, often prescribed for conditions such as schizophrenia, bipolar disorder, and severe depression, have become common components of treatment plans for many elderly patients. However, the clinical rationale for their use in this demographic can be complex, given the myriad of comorbidities that older adults often face. The study by Schneider et al. emphasizes the delicate balance of benefits versus risks involved in the management of these medications among an aging population.

The study highlights that atypical antipsychotics are frequently employed to alleviate behavioral symptoms linked to dementia and other psychiatric disorders. However, this off-label use raises questions about efficacy, safety, and the potential for adverse side effects. Older adults may experience heightened sensitivity to medications due to age-related physiological changes, which can complicate treatment regimens and heighten the risk of cognitive decline or other neurological issues.

One of the core findings of the study is the necessity for thorough evaluations and personalized treatment strategies. The authors advocate for a more nuanced approach to prescribing these medications, one that takes into account the unique health profiles of older patients. This involves not only assessing the immediate therapeutic effects but also considering long-term outcomes related to quality of life. The study underscores the importance of engaging patients and their families in shared decision-making processes, fostering a more holistic approach to treatment.

Furthermore, Schneider et al. discuss the concept of deprescribing, an increasingly recognized practice that involves the systematic reduction or discontinuation of medications that may no longer be necessary or beneficial. Deprescribing is particularly pertinent in older adults who may be subject to polypharmacy—the concurrent use of multiple medications that can lead to adverse drug interactions and heightened risks of hospitalization. By creating a structured framework for evaluating the need for atypical antipsychotics, healthcare providers can enhance patient safety and optimize therapeutic outcomes.

The findings of this study also reinforce the critical role of continuous education and training for healthcare professionals. As new evidence emerges regarding medication management in older populations, it is essential for practitioners to stay informed about best practices and emerging guidelines. The research team advocates for interdisciplinary collaboration, involving pharmacists, geriatricians, and psychiatrists to ensure that all aspects of a patient’s health are considered when making prescribing decisions.

In addition to individual patient assessments, the study also addresses broader implications for health policy. As the prevalence of dementia and other mental health disorders rises among the elderly, there is an increasing need for frameworks that support appropriate prescribing practices in long-term care settings. The authors suggest that policymakers prioritize initiatives that promote education and facilitate interdisciplinary approaches to medication management.

The challenges of prescribing atypical antipsychotics are further compounded by the regulatory environment. Current guidelines vary significantly between regions and healthcare systems, with some advocating for strict protocols while others leave significant discretion to practitioners. This inconsistency can lead to confusion and potential disparities in care. The researchers call for uniform guidelines that can assist practitioners in making informed decisions regarding the use of antipsychotics in older adults.

Ultimately, the study by Schneider et al. serves as a crucial reminder that the challenges of prescribing and deprescribing medications are not merely clinical but also involve ethical considerations about the patient’s autonomy and dignity. As younger generations of healthcare providers emerge, they are innately aware of the need to consider patients as active participants in their treatment plans, which aligns with contemporary philosophies around patient-centered care.

In an era where the longevity of life is coupled with an increasing burden of chronic disease, the timely management of polypharmacy becomes even more critical. Addressing the prescriptions of atypical antipsychotics requires a keen understanding of geriatric pharmacology and a compassionate approach to care. The implications of this study enhance our understanding of how best to navigate these complex waters.

As the research community continues to explore these vital issues, the ongoing dialogue will likely influence future studies aimed at optimizing mental health care for older adults. This is particularly pertinent as the global population of elderly individuals is projected to continue growing exponentially in the coming decades. The responsibility now lies with healthcare systems to adapt and innovate in order to provide the best possible outcomes for this vulnerable population.

In conclusion, Schneider et al.’s study highlights a pressing need for mitigating risks associated with atypical antipsychotic use in older multimorbid patients. By fostering collaborative practices, encouraging patient involvement, and pushing for enhanced educational frameworks, we can collectively work toward revolutionizing the landscape of geriatric psychiatric care. This research not only reflects the current state of our healthcare system but also projects a future where older adults receive the safe and effective treatment they deserve.

Subject of Research: Atypical antipsychotics prescribing and deprescribing in older multimorbid patients

Article Title: Prescribing and deprescribing of atypical antipsychotics in older multimorbid patients

Article References:

Schneider, C., O’Mahony, D., Byrne, S. et al. Prescribing and deprescribing of atypical antipsychotics in older multimorbid patients.
BMC Geriatr 25, 962 (2025). https://doi.org/10.1186/s12877-025-06579-0

Image Credits: AI Generated

DOI: https://doi.org/10.1186/s12877-025-06579-0

Keywords: atypical antipsychotics, geriatrics, medication management, deprescribing, polypharmacy, patient-centered care, dementia, mental health, elderly care.

The heart’s electrical system is intricate and finely tuned, but it can be easily disrupted, particularly in vulnerable populations such as the elderly. One of the critical metrics of heart activity is the QT interval—an essential measure that informs healthcare providers about the heart’s rhythm and conduction system. Recent research has revealed alarming insights into the prevalence of QT interval prolongation among hospitalized geriatric patients, pointing towards startling implications for clinical practice and patient outcomes. This study shines a light on a crucial, yet frequently overlooked aspect of geriatric health.

QT interval prolongation can serve as a marker for increased risk of serious cardiovascular events, including arrhythmias and sudden cardiac death. This risk amplifies in elderly patients who often have multiple comorbidities and polypharmacy, conditions characterized by the use of several medications simultaneously. In many cases, this vulnerable demographic experiences QT interval prolongation due to a combination of age-related physiological changes and the pharmacological properties of medications they ingest. Understanding these factors is vital in providing targeted and effective healthcare interventions for older adults.

In a recent cross-sectional study conducted in Pakistan, researchers investigated the prevalence of QT prolongation and its associated risk factors among hospitalized geriatric patients. The methodology was robust, encompassing a diverse patient population over significant time and control parameters, aiming to ensure the reliability of the findings. This study not only emphasizes the need for heightened awareness of arrhythmogenic potential in elderly patients but also calls for a reassessment of current treatment protocols administered to them.

The results were striking, revealing a significant prevalence rate of QT prolongation within the studied population. The study documented that a substantial number of the patients exhibited prolonged QT intervals, with a clear correlation between age, existing health issues, and use of certain medications. Notably, the findings urge clinicians to exercise caution with particular drugs known to influence heart rhythms. This aspect of medical treatment showcases the necessity for individualized patient care, especially in geriatric settings where patients’ health profiles can be vastly diverse.

Moreover, the implications of this research extend beyond individual patient care. They beckon a broader analysis of prescribing practices in hospitals, prompting healthcare systems worldwide to reconsider their approach to managing elderly patients. With an increase in the geriatric population globally, the healthcare sector faces a pressing need for innovative strategies that prioritize safe prescribing practices, effective monitoring, and enhanced patient education regarding heart health.

In exploring the etiology of QT interval prolongation, the study recorded multiple contributing factors including electrolyte imbalances, renal dysfunction, and concurrent medication use. Each of these factors plays a pivotal role in determining how vulnerable an individual is to experiencing QT prolongation. This complexity underscores the urgent need for comprehensive geriatric assessments that are not only thorough but also consistent.

Another pivotal finding of this research mirrored trends observed in previous studies conducted worldwide. It revealed that specific medications, particularly those with known cardiotoxic effects, were frequently prescribed to older adults without adequate monitoring for potential cardiac risk. The discussion around drug safety in older individuals requires urgent intervention, especially as healthcare providers aim to balance the benefits of treatment with the potential for adverse effects on heart health.

In light of these issues, the research emphasizes the need for implementing automated QT interval screening protocols in clinical settings. Technology can play a crucial role in detecting these changes early and accurately, giving healthcare providers the necessary tools to intervene before serious complications arise. Automated systems could enhance the vigilance required in monitoring QT intervals, thereby improving patient safety and outcomes.

Patient education represents another missed opportunity in the current healthcare framework. Older adults and their caregivers often lack awareness of QT interval ramifications, medications that may pose risks, and the general importance of regular heart health check-ups. Enhanced educational initiatives could empower patients to engage more actively in their care, prompting them to report symptoms and seek follow-up appointments promptly.

The implications of QT interval prolongation transcend the immediate patient experience, influencing broader public health strategies as well. Policymakers may need to reevaluate healthcare guidelines and incorporate QT monitoring into standard practices for geriatric care. Effective strategies should include training programs for healthcare professionals focusing on recognizing risk factors and managing polypharmacy better.

Furthermore, the study brings to light essential questions about the clinical training of healthcare providers. There is an apparent gap in education regarding the risks of QT prolongation in elderly patients, which needs to be addressed through enhanced medical curriculums that prioritize geriatric patient care. By closing this knowledge gap, future healthcare professionals may be better equipped to identify and manage potential complications.

In conclusion, the findings from this recent research serve as a crucial reminder of the importance of vigilance in treating the geriatric population. QT interval prolongation stands as a silent yet significant marker of risk, implicating the urgent need for improved awareness, monitoring, and education within both clinical practice and healthcare policy. By prioritizing these aspects, we can move towards a future where older adults receive the comprehensive and safe healthcare they deserve.

Subject of Research: Prevalence of QT interval prolongation and its risk factors in hospitalized geriatric patients.

Article Title: Prevalence of the QT interval prolongation and its risk factors in hospitalized geriatric patients: findings of a single-center cross-sectional study in Pakistan.

Article References:
Tanveer, H., Ashfaq, M., Sharif, M.J.H. et al. Prevalence of the QT interval prolongation and its risk factors in hospitalized geriatric patients: findings of a single center cross-sectional study in Pakistan.
BMC Geriatr 25, 705 (2025). https://doi.org/10.1186/s12877-025-06418-2

Image Credits: AI Generated

DOI: 10.1186/s12877-025-06418-2

Keywords: QT interval prolongation, geriatric patients, cardiovascular health, arrhythmias, polypharmacy.