The research, conducted at Shanxi Province Cancer Hospital in China, followed 120 patients who underwent radical surgery for laryngeal squamous cell carcinoma between June 2019 and June 2023. Using propensity score matching to balance age, sex, tumor stage, and surgical method, the team compared 60 patients who received systematic combined voice and swallowing rehabilitation against 60 who received routine postoperative care. The rehabilitation program began within 24 to 48 hours after nasogastric tube removal and included graded voice exercises, swallowing training, nutritional management, pain control, and psychological support tailored to each patient.

The scale of the functional deficit after laryngeal cancer surgery is substantial. According to prior research cited in the study, roughly 30 to 50 percent of patients develop dysphagia, experiencing choking during eating and aspiration that raises the risk of malnutrition and aspiration pneumonia. More than 60 percent suffer long-term voice abnormalities such as hoarseness and vocal fatigue, which can drive communication limitations and social avoidance. Laryngeal squamous cell carcinoma accounts for about 95 percent of laryngeal malignancies and roughly 5 percent of all malignancies, making these functional consequences a major public health concern.

The researchers measured outcomes using validated instruments at 6, 12, and 24 months after surgery. Voice function was assessed with the Chinese version of the Voice Handicap Index, a 30-item questionnaire spanning functional, physical, and emotional domains with scores from 0 to 120. Swallowing was evaluated with the Standardized Swallowing Assessment, which scores clinical examination and water-swallow tests from 18 to 46, with higher scores indicating worse function. Dysphagia risk was screened with the Eating Assessment Tool-10, and quality of life was measured with the EuroQol five-dimension questionnaire, converted to a utility index where 1 represents full health.

The results were striking. At 12 months postoperatively, the rehabilitation group scored 35.25 on the Voice Handicap Index compared with 58.70 in the routine care group, a difference that was highly statistically significant. Dysphagia incidence was 10 percent in the rehabilitation group versus 30 percent in the control group. The EQ-5D utility index reached 0.82 in the rehabilitation group compared with 0.68 in the routine care group, and total complication rates fell from 26.67 percent to 11.67 percent. Patient satisfaction scores were also markedly higher, at 87.80 versus 72.21 on a 100-point scale.

Crucially, multivariate regression analysis confirmed that rehabilitation training remained an independent protective factor even after adjusting for age, sex, TNM stage, surgical method, and postoperative radiotherapy. The training was associated with better voice function, better swallowing function, improved quality of life, an 82.4 percent reduction in the risk of long-term dysphagia, and a significantly lower overall risk of complications. Higher TNM stage and total laryngectomy emerged as independent risk factors for poorer functional recovery, while radiotherapy was linked to worse voice and swallowing scores but did not significantly increase dysphagia or complication risk.

The mechanisms behind these gains are rooted in neuromuscular reorganization. Breathing support training, such as abdominal breathing, enhances subglottic pressure and improves vocal efficiency, partially compensating for postoperative changes in vocal fold structure. Laryngeal relaxation techniques reduce compensatory muscle hypertonicity and vocal fatigue, while tracheoesophageal puncture training reconstructs the vibration source for patients after total laryngectomy. On the swallowing side, resistance exercises such as tongue protrusion against resistance strengthen the hyolaryngeal complex, the Mendelsohn maneuver prolongs laryngeal elevation to open the upper esophageal sphincter, and sensory stimulation may lower the swallowing reflex threshold by modulating cortical excitability.

The complication findings carry particular clinical weight. Swallowing posture training, including chin tuck swallowing at 15 to 30 degrees, physically elevates the epiglottis to protect the airway and reduce the risk of pulmonary infection. Dynamic nutritional management based on swallowing assessments interrupts the vicious cycle in which swallowing disorder leads to malnutrition, weakened immunity, and infection. The authors argue that this multimodal approach, addressing voice, swallowing, nutrition, and psychological support together, reflects the World Health Organization’s three-dimensional model of functional, psychological, and social rehabilitation.

Quality of life data tell perhaps the most compelling story. By 12 and 24 months, the EQ-5D utility index in the rehabilitation group had surpassed preoperative levels, with the 24-month value of 0.84 approaching that of the general population. The authors suggest this reflects a virtuous cycle of functional recovery, psychological adaptation, and social participation, in which restored communication and safe eating break the spiral of social withdrawal and anxiety that often follows laryngeal surgery.

The study’s authors caution that the retrospective, single-center design and modest sample size limit the strength of the conclusions, and that physiological differences between partial and total laryngectomy patients complicate direct score comparisons. They call for multicenter randomized controlled trials with larger samples and subgroup analyses stratified by surgical type. Still, the findings offer real-world evidence that structured, early, and sustained voice and swallowing rehabilitation could become a standard component of postoperative care pathways for laryngeal cancer patients, potentially transforming long-term survival into genuinely functional survival.

Subject of Research: Long-term effects of combined voice and swallowing rehabilitation on functional recovery after laryngeal cancer surgery

Article Title: Long-term effects of voice training and swallowing function exercises on postoperative functional recovery in laryngeal cancer patients: a retrospective cohort study

Article References: Liu, J., Fan, G., & Li, W. (2026). Long-term effects of voice training and swallowing function exercises on postoperative functional recovery in laryngeal cancer patients: a retrospective cohort study. Supportive Care in Cancer, 34(11), Article 1112. https://doi.org/10.1007/s00520-026-11302-9

Image Credits: AI Generated

DOI: 10.1007/s00520-026-11302-9

Keywords: laryngeal cancer, voice training, swallowing rehabilitation, dysphagia, quality of life, postoperative complications, laryngectomy, Voice Handicap Index, rehabilitation, head and neck surgery, supportive care, retrospective cohort study