The research team, led by Garima Talukdar and Santosh Prasad Kesari, recruited 461 students from three institutions: Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal College of Nursing, and Sikkim Manipal College of Physiotherapy. Participants, whose mean age was 20.99 years with a standard deviation of 1.78, completed a structured questionnaire administered through Google Forms after providing informed written consent. All respondents were over 18, and the study was conducted with prior approval from the institutional ethics committee, following the internationally recognized ARIA guidelines for allergic rhinitis. The data were then subjected to statistical analysis to identify symptom patterns, triggering factors, and associations with quality of life.

The headline number is striking: 23.86 percent of the students reported having allergic rhinitis, and 24.51 percent reported a positive family history of the condition. That familial clustering is consistent with the well-established genetic component of allergic disease, in which inherited susceptibility to atopy predisposes individuals to develop IgE-mediated hypersensitivity reactions upon exposure to common environmental allergens. What makes the figure particularly notable is the population in question. These are students with medical training, living in a relatively clean Himalayan environment, and yet the prevalence matches or exceeds rates reported in many urban settings, underscoring how widespread the condition has become across diverse geographies.

Awareness of allergic rhinitis among the respondents was remarkably high, at 82 percent, a figure the authors attribute to the participants’ medical backgrounds. Yet awareness alone did not translate into freedom from symptoms or from their consequences. The most commonly reported symptoms were sneezing, affecting 48.3 percent of those with the condition, followed by nasal itching and rhinorrhoea, the persistent watery discharge that characterizes the allergic response. These symptoms arise when inhaled allergens bind to IgE antibodies on mast cells in the nasal mucosa, triggering the release of histamine and other inflammatory mediators that produce itching, sneezing reflexes, and increased vascular permeability.

The culprits behind these reactions were, for the most part, thoroughly ordinary. Household dust and pollen emerged as the major triggering allergens, a finding with clear implications for a region where students spend long hours in hostels, lecture halls, and libraries. House dust mites, which thrive in bedding and upholstered furniture, are among the most potent indoor allergens worldwide, while pollen exposure varies seasonally with local vegetation. Sikkim’s position in the Eastern Himalayas gives it rich floral diversity, and the study suggests that this botanical abundance, combined with indoor dust exposure in shared student accommodation, creates a challenging allergenic environment for susceptible individuals.

Perhaps the most consequential findings concern the downstream effects of the condition on students’ lives. Among those with allergic rhinitis, 35.14 percent reported that it significantly affected their sleep, 33.84 percent said it interfered with daily activities, 29.72 percent reported an impact on academic performance, and 20.39 percent said it undermined their confidence. These are not trivial percentages. Sleep disruption in particular is a known multiplier of allergic disease burden: nasal congestion and nocturnal sneezing fragment sleep architecture, reducing restorative slow-wave sleep and leading to daytime fatigue, impaired concentration, and reduced memory consolidation, all of which directly undermine the demanding cognitive work of medical education.

The statistical analysis confirmed significant associations between allergic rhinitis and impaired quality of life, lending quantitative weight to what students themselves reported. For a population preparing for one of the most intellectually punishing careers in existence, a condition that degrades sleep, focus, and self-assurance by nearly a third of affected individuals is a matter of institutional concern, not merely personal discomfort. The authors argue that the academic burden of allergic rhinitis has been historically underestimated precisely because the disease is rarely life-threatening and its symptoms are episodic rather than constant, allowing it to escape the attention it deserves.

On the treatment side, the study found that antihistamines were the most commonly used medications among affected students. This is in line with standard pharmacological management, but it raises an important nuance highlighted by the authors: the choice of antihistamine matters enormously. First-generation antihistamines such as chlorpheniramine cross the blood-brain barrier and cause sedation, potentially compounding the very cognitive and sleep-related problems they are meant to alleviate. The researchers emphasize that non-sedating pharmacological interventions are essential in this population, since a drowsy medical student facing examinations is scarcely better off than a congested one.

The broader context of the study is the documented global rise in allergic rhinitis prevalence over recent decades, which has made it one of the most common chronic respiratory disorders worldwide. It affects individuals across all age groups and, according to the authors, represents a prevalent and recurring health concern in day-to-day life. Urbanization, changing exposure patterns to indoor allergens, and environmental shifts have all been implicated in this upward trend, and the Sikkim data demonstrate that even students in a mountainous, relatively low-pollution state are not exempt. The condition’s chronicity means that its cumulative impact on a student cohort, measured across semesters of missed sleep and diminished study efficiency, may far exceed what any single snapshot suggests.

The authors conclude that early diagnosis, increased awareness, and the use of non-sedating treatments are essential to improve health outcomes and productivity among healthcare students. Their study, funded by the Dr. Ramdas Pai and Vasanthi Pai Endowment Fund for the promotion of undergraduate research at Sikkim Manipal University, carries a practical message for institutions everywhere: screening for allergic rhinitis and managing it properly is not a luxury but an investment in academic performance. For the roughly one in four students who sneeze their way through lectures in Sikkim, recognizing allergic rhinitis as a genuine obstacle to learning, rather than a harmless inconvenience, may be the first step toward breathing, and studying, easier.

Subject of Research: Prevalence and academic impact of allergic rhinitis among medical and paramedical students in Sikkim, India

Article Title: Prevalence and academic impact of allergic rhinitis among medical students in Sikkim

Article References: Talukdar, G., Kesari, S. P., Saroj, R. K., Pal, K. R., & Hazarika, H. (2026). Prevalence and academic impact of allergic rhinitis among medical students in Sikkim. Discover Social Science and Health. https://doi.org/10.1007/s44155-026-00465-9

Image Credits: AI Generated

DOI: 10.1007/s44155-026-00465-9

Keywords: allergic rhinitis, medical students, Sikkim, prevalence, academic performance, quality of life, allergens, household dust, pollen, antihistamines, sleep disruption, cross-sectional study