Researchers from Boston University Chobanian & Avedisian School of Medicine have been internationally recognized for their groundbreaking contributions to the treatment of war-related posttraumatic stress disorder (PTSD). This prestigious acknowledgment came from the Trauma Recovery Center at Hebrew University of Jerusalem, a center established in direct response to the traumatic aftermath of the October 7, 2023 attacks in Israel. The collaboration epitomizes the confluence of scientific innovation and humanitarian need, bridging continents and cultures through a shared commitment to advancing mental health care for trauma survivors.

Denise M. Sloan, PhD, a distinguished professor of psychiatry at Boston University and senior psychologist clinician investigator at the National Center for PTSD housed within the VA Boston Healthcare System, alongside Brian P. Marx, PhD, professor of psychiatry and deputy director at the same VA center, have played instrumental roles in supporting Israeli clinicians. Their expertise centers on a therapeutic modality they themselves innovated—Written Exposure Therapy (WET)—a brief yet robust intervention designed specifically to address the complex symptomatology associated with PTSD. Their active involvement encompasses not only research but direct knowledge transfer through rigorous training programs at the Trauma Recovery Center.

WET represents a paradigm shift in the psychosocial treatment of PTSD, addressing the core mechanism that often undermines traditional recovery: avoidance. PTSD patients frequently evade trauma-related memories and stimuli, an instinctual behavior that paradoxically perpetuates distress and functional impairment over time. WET strategically confronts this avoidance by guiding individuals to articulate detailed written narratives of their traumatic experiences. This repetitive and controlled exposure fosters habituation to trauma cues, facilitating the desensitization process and diminishing the intensity of emotional responses traditionally associated with such memories.

Clinically, the biological correlates of PTSD—such as tachycardia, hyperarousal, and sweating—are attenuated through WET’s structured approach, as patients progressively engage with their trauma narrative without the debilitating blockade of avoidance. Dr. Sloan explicates that this exposure requires tolerance of negative affect, which paradoxically breeds resilience. Dr. Marx further emphasizes that the therapeutic alliance established during reflective discussions of writing sessions catalyzes cognitive restructuring, aiding patients in reframing the personal significance and contextual understanding of the trauma. This dual mechanism of emotional and cognitive processing underpins WET’s efficacy.

Pioneering research led by Sloan and Marx has firmly established WET as an empirically supported treatment. Their efforts encompass extensive randomized control trials and large-scale effectiveness studies across diverse trauma populations, including combat veterans, sexual assault survivors, and individuals affected by intimate partner violence. The brevity of the intervention—comprising only five sessions—enhances scalability and acceptability, making it particularly suited for contexts with limited mental health resources, such as post-crisis Israel.

Denise Sloan’s academic pedigree includes a clinical psychology doctorate from Case Western Reserve University. Her prolific scholarly output exceeds 150 peer-reviewed publications and several authoritative texts, including co-editing the seminal “Handbook of Traumatic Stress Disorders.” Her editorial tenure with prominent journals like Behavior Therapy and the Journal of Traumatic Stress underscores her influence and dedication to advancing clinical science in traumatic stress.

Brian Marx’s expertise lies in the intersection of behavior therapy and PTSD symptomatology, with a particular focus on memory processes and functional impairment linked to trauma exposure. His roles on multiple editorial boards and as a grant reviewer for key institutions—including the National Institute of Mental Health and the Departments of Defense and Veterans Affairs—reflect a distinguished career dedicated to both research excellence and translational impact. Funding from federal agencies currently supports his ongoing investigations into novel, efficient treatment modalities for PTSD.

The formation of the Trauma Recovery Center at Hebrew University of Jerusalem in the immediate aftermath of the October 7, 2023 attacks reflects a strategic, institutional response to national psychological trauma on an unprecedented scale. The center’s mission is to embed evidence-based trauma treatments into Israel’s public healthcare framework, ensuring accessibility and sustainability. By collaborating with international experts like Sloan and Marx, the center leverages cutting-edge science to address collective trauma and foster societal resilience.

From a public health perspective, the partnership illustrates a model for rapid integration of research-driven interventions in crisis settings, balancing clinical rigor with cultural adaptability. WET’s structured yet flexible approach allows it to be tailored to diverse populations, facilitating widespread implementation. It serves as a beacon of hope and pragmatic therapy for countless survivors navigating the long-term psychological consequences of mass trauma.

In summary, the recognition of Boston University researchers by the Trauma Recovery Center not only honors individual scholarship but highlights the vital importance of international scientific cooperation in trauma care. The adoption of Written Exposure Therapy in Israel epitomizes the practical translation of theoretical advances into lifesaving practice, underscoring the transformative potential of targeted, evidence-based mental health interventions in post-conflict recovery.

Subject of Research: Posttraumatic Stress Disorder (PTSD) treatment development and clinical application

Article Title: Researchers Honored by the Trauma Recovery Center at Hebrew University of Jerusalem

News Publication Date: October 2, 2025

Keywords: Health and medicine, posttraumatic stress disorder, trauma treatment, Written Exposure Therapy, PTSD therapy, trauma recovery, behavioral therapy, clinical psychology, war-related trauma, mental health intervention, psychosocial treatment, evidence-based therapy

These ERC Advanced Grants represent among the most rigorous and selective funding opportunities available in Europe today, specifically designed to empower leading thinkers who operate at the edges of scientific knowledge. The recipients from the Hebrew University exemplify this spirit of pioneering inquiry through their groundbreaking work spanning quantum computing, neuroscience, and pure mathematics. Their successful grant awards are a testimony not only to their individual achievements but also to the institution’s collective commitment to fostering cutting-edge research and innovation.

Prof. Israel Nelken’s project, based at the Edmond and Lily Safra Center for Brain Sciences and the Silberman Institute for Life Sciences, dives deep into the mysteries of auditory continual learning at the cellular and network levels. Despite decades of research into synaptic plasticity revealing much about how memory formation occurs in neural circuits, a lingering paradox remains unresolved: organisms display both remarkable stability in memory retention and the ability to incorporate new information continuously, yet many computational models fail to account for this dual capacity. Nelken’s research aspires to dissect this puzzle by examining how memories are maintained or altered in the behaving rat during periods of intense auditory learning and high memory load—a domain scarcely explored in animal models. This innovative approach challenges prevailing theories and aims to identify the fundamental principles that enable the brain to balance memory stability with the flexibility demanded by lifelong learning.

Turning to the realm of pure mathematics, Prof. Tamar Ziegler’s work epitomizes the fusion of abstract theory with longstanding mathematical conundrums. Holding the Henry and Manya Noskwith Chair in Mathematics at the Einstein Institute of Mathematics, Ziegler’s research exploits sophisticated techniques from ergodic theory and dynamics to tackle profound problems in additive number theory and algebraic geometry. Her prior accomplishments include leveraging dynamics on nilmanifolds to prove advanced Hardy–Littlewood-type estimates, which pertain to the distribution of prime solutions to complex systems of linear equations. Ziegler’s current research probes frontier questions that lie at the confluence of dynamics, number theory, and combinatorics. Moreover, she is pioneering the elucidation of new relationships between stability phenomena in algebraic geometry and dynamic systems, potentially unlocking new vistas in mathematical understanding and methodological synthesis.

Meanwhile, in the cutting-edge field of quantum computing, Prof. Dorit Aharonov is spearheading efforts to redefine the theoretical foundations of quantum information processing in the presence of noise and error. Situated within the School of Engineering and Computer Science, her research addresses two paramount obstacles confronting quantum computing today. From a computer science perspective, Aharonov seeks to expand the repertoire of quantum algorithms by crafting novel algorithmic techniques capable of vastly broadening the scope and efficiency of quantum speed-ups beyond the limited catalog currently known. Simultaneously, from the physics standpoint, her work confronts the pervasive challenge of noise in quantum hardware, which threatens to undermine computational fidelity. By developing a comprehensive theory of quantum complexity that inherently incorporates noise, she aims to transform errors from debilitating hindrances into exploitable resources—reimagining noisy quantum systems as fertile grounds for algorithmic innovation rather than liabilities. This dual-pronged approach promises to elevate our understanding of quantum computational power under realistic conditions and accelerate progress toward practical quantum technologies.

The trio’s achievements resonate profoundly with the ethos of scientific perseverance and intellectual courage, especially in an era where the landscape of research is both increasingly competitive and essential to tackling the complex challenges facing humanity. Prof. Tamir Sheafer, Rector of the Hebrew University, lauded the honorees as embodiments of the university’s excellence, emphasizing that their success on the international stage reflects the dynamic and pioneering spirit that courses through the institution’s academic fabric. Their groundbreaking contributions not only push disciplinary boundaries but also affirm the university’s status as a global hub for high-impact research.

The awarded projects collectively flourish at the intersection of theoretical depth and practical relevance. Nelken’s investigations into neural plasticity promise to elucidate mechanisms underlying memory and learning, with potential implications for neurodegenerative disease understanding and artificial intelligence. Ziegler’s mathematical breakthroughs may inform cryptography, algorithm design, and even theoretical physics, while Aharonov’s advances in quantum algorithmics and noise-resilient computation are essential for realizing the next generation of quantum devices, which could revolutionize fields as varied as materials science, optimization, and secure communications.

Moreover, these endeavors exemplify the interdisciplinary synergy that characterizes modern scientific inquiry. The integration of neuroscience data, mathematical rigor, and quantum theory highlights how cross-pollination between fields can foster novel insights beyond traditional disciplinary confines. This aligns with the broader vision of the ERC and the Horizon Europe programme, designed to catalyze high-risk, high-reward research that dares to rethink foundational assumptions.

As the scientific community eagerly anticipates the outputs of these projects, the recognition afforded by the ERC Advanced Grants not only provides substantial financial backing but also an invaluable platform for increased international collaboration, visibility, and impact. Such support is instrumental in attracting talented researchers and fostering environments where transformative ideas may flourish.

In sum, the recognition of Professors Aharonov, Nelken, and Ziegler by the ERC elevates their visionary research endeavors to new heights. Their work embodies the relentless pursuit of knowledge, addressing some of the most intricate and profound questions in science and mathematics. By tackling challenges ranging from the stability of memory representations in the brain, the deep structures governing prime number distributions, to the complexities of quantum computations amid noise, these scholars are charting pathways that promise to redefine their fields and inspire generations to come.

This milestone also serves as an inspiring reminder of the vital importance of sustained investment in fundamental research. It underscores how universities like Hebrew University of Jerusalem serve as crucibles for innovation, driven by talented individuals whose ideas ripple outward to transform technology, theory, and society at large. At a time when global challenges demand bold scientific solutions, the university’s triumphant ERC success stories illuminate the enduring power of curiosity, rigor, and resilience.

In recognition of these accomplishments, the scientific world watches closely as these projects unfold, anticipating discoveries that will deepen our understanding of the natural world, expand the limits of computation, and intertwine disparate mathematical realms into coherent frameworks. Their success is not only a triumph for themselves and their home institution but also a beacon for international science, shining a light on the extraordinary potentials unlocked when brilliance meets opportunity.

Subject of Research: Auditory continual learning and memory stability in neuroscience; dynamics and additive number theory in mathematics; quantum computing algorithms and quantum complexity under noise.

Article Title: Hebrew University of Jerusalem Researchers Awarded ERC Advanced Grants for Transformative Work in Neuroscience, Mathematics, and Quantum Computing

News Publication Date: [Not provided]

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Image Credits: Maxim Dinstein

Keywords: Computer Science, Mathematics, Neuroscience