EBV antigens and HLA interaction – Science https://scienmag.com Thu, 29 Jan 2026 06:54:11 +0000 en-US hourly 1 https://wordpress.org/?v=7.1 https://scienmag.com/wp-content/uploads/2024/07/cropped-scienmag_ico-32x32.jpg EBV antigens and HLA interaction – Science https://scienmag.com 32 32 73899611 Population Sequencing Reveals EBV DNA Persistence https://scienmag.com/population-sequencing-reveals-ebv-dna-persistence/ Thu, 29 Jan 2026 06:54:11 +0000 https://scienmag.com/population-sequencing-reveals-ebv-dna-persistence/ It looks like your input was cut off mid-sentence. From what you’ve provided, the passage discusses the challenges in resolving associations between the HLA locus and immune-mediated complex traits, due to factors like allelic diversity, population heterogeneity, and the lack of well-estimated antigens.

Here’s a brief summary of the passage so far:

  • The HLA locus is tightly linked to immune-related traits, but understanding the specific associations is difficult.
  • The Epstein-Barr Virus (EBV) proteome provides a set of candidate antigens that interact with these HLA alleles.
  • Because these alleles variably present EBV antigens, this affects the presence of EBV DNAemia (presence of EBV DNA in blood).
  • The researchers assembled four-digit HLA allele data from donors of Non-Finnish European (NFE) or European (EUR) ancestry from UK Biobank (UKB) and All of Us (AOU) cohorts.
  • They performed multivariate regression to find associations between HLA alleles and EBV DNAemia.
  • They identified 42 associated HLA alleles in total (18 class I and 24 class II alleles) with a nominal P-value threshold (not fully detailed due to cutoff).

If you provide the rest of the text or your specific questions about this, I could assist further! Would you like me to help interpret this study further, summarize more, or analyze particular parts?

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