Divergent epigenetic profile underlie pubertal disorders in MKRN3-associated central precocious puberty and Prader–Willi syndrome: insights from a frameshift variant

Juliet Wilcox — Mon, 31 Aug 2026 04:31:04 +0000

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Subject of Research: Medicine

Article Title: Divergent epigenetic profile underlie pubertal disorders in MKRN3-associated central precocious puberty and Prader–Willi syndrome: insights from a frameshift variant

Article References: Jin, Y.-Y., Wang, X., Yang, L., Mu, J., & Luo, F.-H. (2026). Divergent epigenetic profile underlie pubertal disorders in MKRN3-associated central precocious puberty and Prader–Willi syndrome: insights from a frameshift variant. World Journal of Pediatrics, 22(2), 258-271. https://doi.org/10.1007/s12519-026-01017-6

Image Credits: AI Generated

DOI: 10.1007/s12519-026-01017-6

Keywords: central precocious puberty epigenetics, differential epigenetic profiles in pubertal diseases, epigenetic biomarkers for pubertal disorders, epigenetic modifications in developmental disorders, frameshift variants in MKRN3, genetic and epigenetic interplay in puberty, MKRN3 gene mutations, molecular basis of pubertal timing, neuroendocrine regulation of puberty, Prader-Willi syndrome epigenetic mechanisms, pubertal disorder epigenetic differences, role of MKRN3 in puberty regulation

differential epigenetic profiles in pubertal diseases – Science

Divergent epigenetic profile underlie pubertal disorders in MKRN3-associated central precocious puberty and Prader–Willi syndrome: insights from a frameshift variant