Carcinogens

Oncotarget Volume 11, Issue 12 reported outside its natural niche, the cultured prostate cancer stem cells lost their tumor-inducing capability and stem cell marker expression after approximately 8 transfers at a 1:3 split ratio.Credit:…

Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear…

Scientists have identified a motor protein that helps cells access DNA information when they need itCredit: Jack Kaiser/Square Cell & Joel Mackay/University of Sydney Australian scientists have unravelled part of the mystery about…

The cover for issue 12 of Oncotarget features Figure 11, 'Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone 12)' by Abdelfettah, et al.Credit: Correspondence to - Dominique Leprince -…

Oncotarget Volume 11, Issue 11 reported that relapsed APL, particularly in the high-risk subset of patients, remains an important clinical problem.Credit: Correspondence to - Joaquin J. Jimenez - [email protected] Oncotarget Volume…

Oncotarget Volume 11, Issue 11 reported that at clinical progression, 64 EGFR T790M plasma positive patients were subjected to second line-treatment with osimertinib and strictly monitored during the first month of therapy.Credit:…

Oncotarget Volume 11, Issue 11 reported that in order to understand the molecular mechanism of the dependency in MM, the research team examined gene expression changes upon DOT1L inhibition in sensitive and insensitive cell lines and…

Oncotarget Volume 11, Issue 11 reported that in this preclinical study, we characterized the binding affinity and selectivity of quizartinib, a small-molecule inhibitor of FLT3, and AC886, the active metabolite of quizartinib, compared with…

CHAPEL HILL-- An analysis of evidence from multiple scientific studies found six substances that have a strong link to bladder cancer in the urine of people who had used electronic cigarettes and sometimes other tobacco products,…

The cover for issue 11 of Oncotarget features Figure 6, "Effects of AZD8186 in combination with anti-PD1 on syngeneic models," by Owusu-Brackett, et al.Credit: Correspondence to - Funda Meric-Bernstam - [email protected] The cover for…

Oncotarget Volume 11, Issue 10 reported that there are not standardized predictive biomarkers able to identify patients who benefit most from treatmentsCredit: Correspondence to - Fabrizio Citarella - [email protected] Oncotarget…

Oncotarget Volume 11, Issue 10 reported that dysregulation of noncoding micro RNA molecules has been associated with immune cell activation in the context of Helicobacter pylori-induced gastric inflammation as well as carcinogenesis, but…

Oncotarget Volume 11, Issue 10 reported that the statistically associated Cp G sites were analyzed in blood samples from two separate atherothrombotic stroke cohorts, ischemic stroke-cohort 1: 37 atherothrombotic patients and 6 controls,…

The cover for issue 10 of Oncotarget features Figure 3, 'Overall survival (OS) for high (red) versus low (black) risk groups in the (A) OSU, (B) TCGA, and (C) SNU resected cohorts,' by Wolfe, et al.Credit: Correspondence to - Terence M.…

Researchers warn that vaping can cause health-damaging chemical reactionsCredit: RCSI A chemical found in some vaping products can produce a highly toxic gas when heated up, according to new research from RCSI University of Medicine…

The Physicians Committee for Responsible Medicine--a nonprofit with more than 25,000 members in California--filed a lawsuit against the State of California on March 11 for failing to include cancer-causing processed meat--such as hot…

Credit: (The University of Arizona Health Sciences TUCSON, Ariz. - Multiple past studies have reported that, compared to whites, Native Americans have relatively high cigarette use, and this has contributed to speculation that Native…

The cover for issue 9 of Oncotarget features Figure 6, 'BCL6 knock-out in a DLBCL xenograft induces tumor stasis,' by Schlager, et al.Credit: Manfred Koegl -- [email protected] The cover for issue 9 of Oncotarget…

WASHINGTON - Scientists at the Environmental Working Group and Indiana University have for the first time conducted a review of 26 fluorinated chemicals, or PFAS, and found that all display at least one characteristic of known human…

Peer reviewed -- Systematic review -- Humans Omega-3 fats do not protect against cancer - according to new research from the University of East Anglia. Increased consumption of omega 3 fats is widely promoted globally because of a…