Carcinogens

Genome editing in farm animalsCredit: A. Heddergott / TUM Researchers at the TUM have demonstrated a way to efficiently study molecular mechanisms of disease resistance or biomedical issues in farm animals. Researchers are…

WINSTON-SALEM, N.C. - April 14, 2021 - Investigators at Wake Forest School of Medicine, part of Wake Forest Baptist Health, have identified a set of new genetic markers that could potentially lead to new personalized treatments for lung…

Credit: Kadi Lõhmussaar, copyright Hubrecht Institute Researchers from the group of Hans Clevers (Hubrecht Institute) developed the first patient-derived organoid model for cervical cancer. They also modelled the healthy human cervix using…

RICHMOND, Va. (April 12, 2021) -- E-cigarettes that deliver a cigarette-like amount of nicotine are associated with reduced smoking and reduced exposure to the major tobacco-related pulmonary carcinogen, NNAL, even with concurrent smoking,…

How does vaping affect cells, and can it cause DNA damage?Credit: Toxys Imperial Brands scientists have utilised Toxys' ToxTracker suite of stem-cell based in-vitro assays, which provide mechanistic insight into the…

Vaping cessation interest is highest among former cigarette smokers, MUSC Hollings Cancer Center researchers findCredit: MUSC Hollings Cancer Center More than 60% of U.S. adults who vape are interested in quitting, according to a study…

Revisions expand screening to more patients at high riskCredit: UVA Health Through his role on the U.S. Preventive Services Task Force, UVA Health's Li Li, MD, PhD, MPH, has helped develop new lung cancer screening guidelines that…

Updated USPSTF LCS guidelines based solely on age, pack-years, and quit-years perpetuate eligibility disparities among racial and ethnic minorities, although incorporating certain risk prediction models may help reduce such…

The Oncotarget article provides evidence that antitumor activity and prolonged stable disease are achieved with Z-endoxifen despite prior tamoxifen therapy.Credit: Correspondence to - Alice P. Chen - [email protected] Oncotarget…

Replacing an old couch with a new one free of flame retardants reduces harmful exposures in the home A new study shows that when people replace their old couch with a new one that has no added flame retardants, levels of the harmful…

Hydroxyprogesterone caproate may contribute to increasing rates of early-onset cancer, researchers say WASHINGTON--Exposure in the womb to a drug used to prevent miscarriage appears to raise the offspring's cancer risk decades later,…

Consumption of ultra-processed foods and drink could increase the risk of developing colorectal cancer. This was the conclusion of a large study undertaken by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the…

Credit: CWRU CLEVELAND--A new technique for sampling and testing cells from Barrett's esophagus (BE) patients could result in earlier and easier identification of patients whose disease has progressed toward cancer or whose disease…

This Oncotarget study had significantly lower mutation rates in ASXL1 and SETBP1, and a higher rate of muTET2/wtASXL1Credit: Correspondence to - Jie-Gen Jiang - [email protected] Oncotarget published "Cytogenetic and molecular…

Dr. Glenn J. Hanna from CCR/NCI in Bethesda, MD as well as The Dana-Farber Cancer Institute in Boston Massachusetts said, "Merkel cell carcinoma (MCC) is a relatively rare cancer, with roughly 400 cases per 100,000 persons each year in the…

The Oncotarget data shed new light on the biochemical mechanisms behind ibuprofen's action on alternative spliced RAC1B and may support its use in personalized approaches to CRC therapy or chemoprevention regimens.Credit: Correspondence to…

The present Oncotarget work shed light on a brief mechanistic framework of PTs aggressive nature and present potential biomarkers to differentiate overlapping FELs that would be of practical utility in augmenting existing diagnosis and…

In this Oncotarget study, the authors characterized the mutational and neoantigen burden between primary and first recurrence tumors in 23 patients with HNSCCCredit: Correspondence to - Brian A. Van Tine - [email protected] Oncotarget…

UMass Amherst research suggests propylparaben is an endocrine disruptorCredit: UMass Amherst Low doses of propylparaben - a chemical preservative found in food, drugs and cosmetics - can alter pregnancy-related changes in the…

This @Oncotarget study indicates that HIPK2 isoform 3, the main HIPK2 isoform expressed in NSCLC, promotes YAP/TEAD transcriptional activity in NSCLC cellsCredit: Correspondence to - Liang You - [email protected] Oncotarget published…