Researchers recruited the participants from the HEAL Together trial and conducted semi-structured interviews at a methadone clinic in a low-income urban neighborhood in Baltimore, Maryland. The interviews examined how participants perceived their neighborhoods and how stressors associated with finances, housing stability, transportation, and the built environment influenced methadone treatment engagement and recovery experiences. The researchers analyzed interview transcripts using both inductive and deductive thematic analysis. They developed a codebook from the coded material and then derived main themes and subthemes from it.

Economic stressors were among the most prominent issues identified in the interviews. Financial difficulties emerged as a major trigger that could disrupt engagement with treatment, while residential instability and transportation challenges were also described as barriers to consistent attendance. Participants discussed neighborhood features more broadly, including the surrounding built environment, as factors that could affect their treatment experiences. Because the study was qualitative, these findings represent the experiences and interpretations reported by 18 participants rather than estimates of how frequently each barrier occurs.

Pervasive exposure to drugs was another prominent neighborhood stressor in participants’ accounts. Interviewees described drug exposure as a feature of the local environment that could disrupt their engagement with methadone treatment. At the same time, many participants said they had developed personal strategies to avoid high-risk situations. Their accounts show deliberate efforts to sustain engagement despite environmental pressures. Strong motivation to remain in treatment was also widely reported, suggesting that neighborhood stressors did not eliminate participants’ desire to continue receiving care.

The study offers a focused perspective on treatment engagement among adults with opioid use disorder in one Baltimore setting. Its small, exploratory qualitative design can illuminate recurring experiences, priorities, and coping strategies identified by participants, but it cannot establish the prevalence of these barriers among all people receiving methadone treatment. The findings are also limited to the clinic, trial sample, and urban context examined. The results do not test particular interventions or demonstrate clinical benefit. Instead, they indicate that financial instability and drug exposure can pose substantial challenges to treatment engagement while also showing that coping strategies and motivation may help participants sustain care. Addressing economic and community barriers and reinforcing patient-driven coping and support mechanisms could inform future efforts to improve engagement and reduce opioid-related disparities in urban communities.

Subject of Research: How adults with opioid use disorder in Baltimore described neighborhood stressors affecting methadone treatment engagement

Article Title: The role of neighborhood stressors in methadone treatment engagement: an explorative qualitative study

Article References: Anane, J. S., Nahabedian, S., Butler, J., Kalan, E., Alcalá, H. E., Belcher, A., Bradley, V. D., Milam, A. J., & Magidson, J. F. (2026). The role of neighborhood stressors in methadone treatment engagement: an explorative qualitative study. Addiction Science & Clinical Practice. https://doi.org/10.1186/s13722-026-00732-9

Image Credits: AI Generated

DOI: 10.1186/s13722-026-00732-9

Keywords: methadone treatment, opioid use disorder, treatment engagement, neighborhood stressors, financial hardship, housing instability, drug exposure, qualitative interviews, Baltimore, patient resilience, role, neighborhood