Study supports link between COVID-19 and “COVID Toes”

There’s considerable controversy over whether “COVID toes”–red sores or lesions on the feet and hands in children and young adults–are truly caused by COVID-19. A new study published in the British Journal of Dermatology provides evidence in support of the link.

In most cases, affected individuals test negative with traditional COVID-19 tests involving throat swabs and measurements of circulating antibodies, but this study’s investigators found that the SARS-CoV-2 virus that causes COVID-19 was present in skin biopsies in children with symptoms of COVID toes, despite negative results from traditional tests.

Analyses detected the virus in skin’s blood vessel endothelial cells, as well as in the sweat glands. Electron microscopy in one biopsy also found evidence of viral particles within endothelial cells.

“Our findings support a causal relation of SARS-CoV-2 with COVID toes. Endothelial damage induced by the virus could be the key mechanism causing these lesions,” said lead author Isabel Colmenero, MD, of Hospital Infantil Universitario Niño Jesús, in Spain. “Furthermore, vascular damage could also explain some clinical features seen in patients with severe COVID-19.”

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Additional Information

Link to Study: https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.19327

About Journal

British Journal of Dermatology, BJD, is a top-ranked international dermatology journal, publishing the highest-quality research to advance the understanding and management of skin disease to improve patient outcomes. The BJD has distinct sections for clinical trials, guidelines, translational research, epidemiology and qualitative and outcomes research.

About Wiley

Wiley drives the world forward with research and education. Through publishing, platforms and services, we help students, researchers, universities, and corporations to achieve their goals in an ever-changing world. For more than 200 years, we have delivered consistent performance to all of our stakeholders. The Company’s website can be accessed at http://www.wiley.com.

Media Contact
Penny Smith
[email protected]
http://dx.doi.org/10.1111/bjd.19327

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