Study shows importance of Quality of Life scores as prognostic factors in cancer patients

Cancer patients own reporting of their quality of life can be important in predicting the outcome of their disease, say researchers from the European Organisation for Research and Treatment of Cancer (EORTC). Until recently, reports from clinicians on issues such as patient age and tumour status were used primarily in determining prognoses, but now researchers have shown conclusively that patient-reported outcomes (PROs) have considerable value in predicting survival.

In a paper1 published in The Lancet Oncology today (2 December 2019). Dr Andrew Bottomley,  EORTC Assistant Director and Head of the Quality of Life Department, EORTC, Brussels, Belgium, together with colleagues from seven countries, report the findings of a meta-analysis of 44 clinical trials carried out between 2006 and 2018 on patients with cancer that report QoL scores.  “We saw that, each year, the scientific literature was populated with dozens of new analyses showing the value of QoL scores, but these were single analyses and many of the trials had limited methods,” says Dr Bottomley. “We decided to try to follow up an earlier EORTC analysis2 that showed QoL was important, but that methods and standards of its analysis needed improvement.”

After reviewing the literature, the authors identified 44 Phase 2 or 3 randomised controlled trials that met the strict criteria for inclusion in their analysis. These covered results 28 281 patients across 13 different cancer types. Sample sizes among the studies ranged from 63 to 1152 patients, and a total of 23 122 patients completed PRO assessments. The main PRO tools used to assess the patients were the EORTC Quality of Life Core questionnaire and the Functional Assessment of Cancer Treatment questionnaire. These were then combined with clinical factor assessments such as performance status, tumour size, and serum markers.

In 41 of the 44 studies included, or 93%, the researchers found that at least one PRO domain, such as physical functioning or pain, was significantly associated with overall survival after other clinical variables had been controlled for. “This is an important result that, additionally, allowed us to confirm that methods and standards of collecting and analysing QoL data have improved since the original review some ten years ago, though we still need some methodological improvements if we are to optimise the prognostic value of these data. We plan to do a further analysis in five years’ time to check that future studies have improved methods further, whether clinical triallists are using these results to stratify patients in trials, and the extent to which they are being used as prognostic indicators,” Dr Bottomley says.

QoL assessment is becoming increasingly important in oncology. Governments are starting to collect data not only from cancer clinical trials, but also from patients undergoing standard hospital care. This can not only help health services understand patients’ needs, but also allow for QoL mapping across countries and perhaps even more widely. “We are seeing a move not just out of research, and single or multiple hospitals, but into country-level data with all the impact on policy that that implies,” says Dr Bottomley.

In demanding better standards for future research in the field of prognostic prediction – being able to tell patients what survival duration they can expect – the researchers hope that patients will be able to better adapt their lives to the impact of the cancer diagnosis on their survival. “Although this will not alter practice, it will encourage clinicians to take more interest in patients’ QoL scores and to understand their importance. They are vital in making services and care specific for each cancer patient. ‘Targeted treatment’ is much discussed in the context of pharmaceuticals, but QoL scores also allow us to ‘target’ the direct needs and concerns of the patient rather than just relying on tumour size or organ-specific problems,” Dr Bottomley concludes.

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1Mierzynska M, Piccinin C, Pe M, Martinelli F, Gotay C, Coens C, Mauer M, Eggermont A, Groenvold M, Bjordal K, Reijneveld J, Velikova G, Bottomley A. Prognostic value of patient-reported outcomes from international randomised clinical trials on cancer: a systematic review. The Lancet Oncology. 2019;20(12):e683-96

2Gotay CC, Kawamoto CT, Bottomley A, Efficace F. The prognostic significance of patient-reported outcomes in cancer clinical trials.

J Clin Oncol 2008; 26: 1355-63.

About EORTC

EORTC is an academic clinical research organization, bringing together European clinical investigators from all disciplines across all tumour types to conduct research that improves quality of life and survival of cancer patients. Research spans translational to large, prospective, multi-centre, phase III clinical trials that evaluate new therapies and treatment strategies as well as patient quality of life. EORTC network comprises more than 5300 professionals in over 930 hospitals and institutes in more than 30 countries supported by 244 staff in its headquarters in Brussels.

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