Friday, June 9, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Cancer

Study reveals factors in metabolism that can enhance efficiency of treatment for gynecologic tumors

November 18, 2021
in Cancer
0
Share on FacebookShare on Twitter

Blood plasma from women with ovarian and uterine cancer can contain molecules that suggest whether they will respond well to chemotherapy or suffer a relapse, according to a study conducted by researchers in the Department of Gynecology at the Federal University of São Paulo’s Medical School (EPM-UNIFESP) in Brazil, in partnership with colleagues at the University of California Irvine (UCI) in the United States. 

Treatment for gynecologic tumors

Credit: Paulo D’Amora

Blood plasma from women with ovarian and uterine cancer can contain molecules that suggest whether they will respond well to chemotherapy or suffer a relapse, according to a study conducted by researchers in the Department of Gynecology at the Federal University of São Paulo’s Medical School (EPM-UNIFESP) in Brazil, in partnership with colleagues at the University of California Irvine (UCI) in the United States. 

The study sample consisted of 50 women with ovarian and endometrial tumors who were submitted to surgery and first-line chemotherapy. The findings are published in Gynecologic Oncology.

“Our aim was to measure the metabolic signatures – molecules originating in the metabolism and present in the bloodstream – that could be associated with a specific illness or condition,” said physician Paulo D’Amora, a member of the steering committee of EPM-UNIFESP’s Molecular Gynecology and Metabolomics Laboratory, and holder of a scholarship from FAPESP’s Young Investigator Program.

In this case, he explained, the study involved analyzing important compound classes such as the amino acids valine and phenylalanine (linked to immunity), and lipids such as the acylcarnitines, lysophosphatidylcholines and sphingomyelins (associated with alterations that lead to stimulation of inflammatory pathways and energy expenditure).

The analysis was performed by mass spectrometry, a technique widely used by clinical laboratories worldwide to identify and quantify substances in biological samples. 

“With the aid of a next-generation mass spectrometry system, we measured the ions emitted by the compounds of interest in the plasma samples collected from the patients,” D’Amora said. “Ions are accelerated and fragmented in the spectrometer. Each metabolite has a specific fragmentation pattern, a unique identity.” 

The results pointed to the patients who were platinum-sensitive or platinum-resistant. Chemotherapy against these gynecologic tumors typically involves drugs that contain platinum. 

The participants were divided into two groups: 38 platinum-sensitive patients (83% of the total), and eight platinum-resistant patients (17%). The spectrometry results were correlated with those of clinical and laboratory exams and, after a metabolomic analysis, led to information on the patients’ clinical response, such as disease-free survival, time to progression and overall survival.

The researchers began with these types of tumor because they are sensitive to chemotherapy with platinum-based drugs. They were able to identify patients with metabolic profiles associated with the best clinical response and prognosis, or with unfavorable profiles and a poor prognosis. This information enables physicians to personalize treatment, enhancing its efficiency and the probability of a cure. 

The results point to a future in which oncologists will use a blood test performed in the clinic to discover the patient’s metabolic signature and use it to help decide on the best way to manage the case. 

“We’re working on ways of ensuring that the biomarkers and algorithms found in the study can achieve the validation levels required by regulators in Brazil and abroad so as to win accreditation for their use in laboratory medicine and clinical pathology. Once that happens, they can be used in clinical practice,” said D’Amora, who in 2016 and 2017 won Scholar-in-Training Awards from the American Association for Cancer Research (AACR). 

 

About São Paulo Research Foundation (FAPESP)

The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at www.fapesp.br/en and visit FAPESP news agency at www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe.



Journal

Gynecologic Oncology

DOI

10.1016/j.ygyno.2021.08.001

Article Title

“Platinum resistance in gynecologic malignancies: Response, disease free and overall survival are predicted by biochemical signature: A metabolomic analysis

Article Publication Date

24-Aug-2021

Tags: efficiencyenhancefactorsgynecologicmetabolismrevealsstudytreatmenttumors
Share26Tweet16Share5ShareSendShare
  • Schrödinger’s cat code

    Schrödinger’s cat makes better qubits

    65 shares
    Share 26 Tweet 16
  • The problems with coal ash start smaller than anyone thought

    66 shares
    Share 26 Tweet 17
  • ‘Revolutionary’ research discovers new cause of cancer coming from inside us

    65 shares
    Share 26 Tweet 16
  • Birmingham spinout to develop 20-minute test following surge in sexually transmitted infections

    64 shares
    Share 26 Tweet 16
  • Taurine may be a key to longer and healthier life

    64 shares
    Share 26 Tweet 16
  • Nearly 70% of private label avocado oil rancid or mixed with other oils

    67 shares
    Share 27 Tweet 17
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

UTHSC researchers’ work on human pangenome aids understanding of common chromosomal abnormality

Null results research now published by major behavioral medicine journal

Multiple sclerosis more prevalent in Black Americans than previously thought

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 206 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In