Bed rest is often used to simulate the effects of microgravity, such as during space flight, on the body’s bones and muscles. New research published in The FASEB Journal examined the effects of 10 days of bed rest on various markers of musculoskeletal health in 10 young male volunteers.
“During space flight, changes occur over a period of weeks to months, first in the muscle and then in the bone,” the authors wrote. Their experiments over just 10 days suggested a possible early involvement of the molecule irisin in muscle and bone adaptation to microgravity-simulated conditions.
Results indicated that irisin may help to prevent the onset of atrophy and aging of skeletal muscle, and that low irisin blood levels could represent an early prognostic marker of muscle atrophy in microgravity environments.
URL upon publication: https://onlinelibrary.wiley.com/doi/10.1096/fj.202201005RR
NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, [email protected]
About the Journal
The FASEB Journal publishes high quality and impactful multidisciplinary research covering biology and biomedical sciences at every level of organization: atomic, molecular, cell, tissue, organ, organismic, and population. The journal’s scope includes the spectrum of biological and biomedical sciences as well as interdisciplinary research cutting across multiple fields and extending in related areas. The FASEB Journal welcomes manuscripts on basic and translational research as well as on pre-clinical and early clinical research.
Wiley is one of the world’s largest publishers and a global leader in scientific research and career-connected education. Founded in 1807, Wiley enables discovery, powers education, and shapes workforces. Through its industry-leading content, digital platforms, and knowledge networks, the company delivers on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on Facebook, Twitter, LinkedIn and Instagram.
The FASEB Journal
Impact of 10-day Bed Rest on Serum Levels of Irisin and markers of Musculoskeletal metabolism
Article Publication Date