stem cells can differentiate into neurons and may be useful post-stroke therapeutics

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Credit: Mary Ann Liebert, Inc., publishers

New Rochelle, NY, October 26, 2018-Researchers have performed a careful comparison between locally generated, ischemia-induced, multipotent stem cells (iSCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) in an effort to determine which cell type has greater central nervous system (CNS) repair capacity. Their results show that the iSC characteristics make them more promising candidates as CNS injury therapeutics. The study is published in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Stem Cells and Development website through November 26, 2018.

Takayuki Nakagomi, MD, PhD, with colleagues from the Hyogo College of Medicine and from the Kwansei Gakuin University School of Science and Technology, Hy?go, Japan, coauthored the article titled "Comparative Characterization of Ischemia-Induced Brain Multipotent Stem Cells with Mesenchymal Stem Cells: Similarities and Differences". Although evidence has shown that grafted mesenchymal stem cells can improve neuronal function after a stroke, most of these cells never reach the target injured brain regions. However, a regional induction of stem cells occurs after ischemia that may provide greater opportunity to restore neuronal function. Thus, the authors of this study extracted iSCs from the ischemic regions of post-stroke mice and collected and prepared MSCs from bone marrow. They then compared the gene and protein expression, multipotency, and neuronal differentiation capacity of the two stem cell types. Ultimately, many similarities were identified between MSCs and iSCs, but only iSCs exhibited the potential for neuronal differentiation, thus establishing a case for their exploration as CNS therapeutic agents.

"Having recently demonstrated that ischemia-induced multipotent stem cells are present within the post-stroke human brain, the authors here seek to clarify how the potential of this fascinating cell population differs from that of mesenchymal stem cells." says Editor-in-Chief Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.

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About the Journal

Stem Cells and Development is an authoritative peer-reviewed journal published 24 times per year in print and online. The Journal is dedicated to communication and objective analysis of developments in the biology, characteristics, and therapeutic utility of stem cells, especially those of the hematopoietic system. A complete table of contents and free sample issue may be viewed on the Stem Cells and Development website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Cellular Reprogramming, Tissue Engineering, and Human Gene Therapy. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

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Original Source

https://home.liebertpub.com/news/ischemia-induced-stem-cells-can-differentiate-into-neurons-and-may-be-useful-post-stroke-therapeutics/2464 http://dx.doi.org/10.1089/scd.2018.0075

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