Stanford researchers engineer 3-D hydrogels for tissue-specific cartilage repair
New Rochelle, N.Y., July 26, 2017–Unlike the one-size-fits-all, homogeneous approach to tissue engineering for cartilage replacement, a new study reports the ability to encapsulate cartilage-forming chondrocytes and mesenchymal stem cells in 3D hydrogels within a stiffness gradient. Researchers describe the formation of articular cartilage that shows zonal organization of the cells as it appears in native cartilage, as reported in an article be published in Tissue Engineering, Part A, peer-reviewed journal from Mary Ann Liebert, Inc., publishers.. The article is available free on the Tissue Engineering website until August 25, 2017.
Danqing Zhu, Pavin Trinh, Dr. Xinming Tong, and Prof. Fan Yang, Stanford University, coauthored the article entitled "Mimicking Cartilage Tissue Zonal Organization by Engineering Tissue-scale Gradient Hydrogels as 3D Cell Niche."
The tissue-scale gradient hydrogels provide a 3D cell growth environment that could be readily adapted to deliver different tissue-specific biochemical and mechanical cues across the gradient. These cues would guide cell behavior, extracellular matrix deposition, and zonal organization of the tissue engineered construct to optimize it for various applications.
"The ongoing sophistication in the tissue engineering of cartilage includes multiple modes of tissue induction, including micromechanical manipulation, as in this work," says Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.
Research reported in this publication was supported by the National Institutes of Health under Award Number R01DE024772. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
About the Journal
Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Leadership of Tissue Engineering Parts B (Reviews) and Part C (Methods) is provided by John P. Fisher, PhD, University of Maryland and John A. Jansen, DDS, PhD, Radboud University, respectively. Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed on the Tissue Engineering.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.