Sleeping brain’s complex activity mimicked by simple model
Researchers have built and tested a new mathematical model that successfully reproduces complex brain activity during deep sleep, according to a study published in PLOS Computational Biology.
Recent research has shown that certain patterns of neuronal activity during deep sleep may play an important role in memory consolidation. Michael Schellenberger Costa and Arne Weigenand of the University of Lübeck, Germany, and colleagues set out to build a computational model that could accurately mimic these patterns.
The researchers had previously modeled the activity of the sleeping cortex, the brain's outer layer. However, sleep patterns thought to aid memory arise from interactions between the cortex and the thalamus, a central brain structure. The new model incorporates this thalamocortical coupling, enabling it to successfully mimic memory-related sleep patterns.
Using data from a human sleep study, the researchers confirmed that their new model accurately reproduces brain activity measured by electroencephalography (EEG) during the second and third stages of non-rapid eye movement (NREM) sleep. It also successfully predicts the EEG effects of stimulation techniques known to enhance memory consolidation during sleep.
The new model is a neural mass model, meaning that it approximates and scales up the behavior of a small group of neurons in order to describe a large number of neurons. Compared with other sleep models, many of which are based on the activity of individual neurons, this new model is relatively simple and could aid in future studies of memory consolidation.
"It is fascinating to see that a model incorporating only a few key mechanisms is sufficient to reproduce the complex brain rhythms observed during sleep," say senior authors Thomas Martinetz and Jens Christian Claussen.
In your coverage please use this URL to provide access to the freely available article in PLOS Computational Biology: http://dx.plos.org/10.1371/journal.pcbi.1005022
Citation: Schellenberger Costa M, Weigenand A, Ngo H-VV, Marshall L, Born J, Martinetz T, et al. (2016) A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation. PLoS Comput Biol 12(9): e1005022. doi:10.1371/journal.pcbi.1005022
Funding: This work was supported by the grants "Plasticity and Sleep" (SFB 654) and the Graduate School "Computing in Medicine and Life Sciences" (GS-635) from the German Research Foundation and US-German Collaboration in Neuroscience (grant 01GQ1008) from the German Federal Ministry of Education and Research and the European Union Human Brain Project SP3 – Cognitive Architectures. The funders had no role in study design, data
Competing Interests: The authors have declared that no competing interests exist.
Michael Schellenberger Costa